Changes in the Gene Expression Profiles of the Inferior Colliculus Following Unilateral Cochlear Ablation in Adult Rats

Kil, Hog Kwon; Kim, Kyung Woon; Lee, Da-Hye; Lee, So Min; Lee, Chang Ho; Kim, So Young

doi:10.1007/s10528-021-10034-1

Cited by 2 publications

(1 citation statement)

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“…In peripherin knock-out mice, the type II SGNs were disrupted and the OHCs lost their innervation, causing a greater vulnerability to acoustic overstimulation [ 67 ]. The reduced synaptic transmission of the type II SGNs, after unilateral cochlear ablation, resulted in decreased peripherin mRNA in the inferior colliculus [ 68 ]. In addition to being important for neurite outgrowth, peripherin seems to also be involved in vesicular traffic.…”

Section: Peripherin Functionsmentioning

confidence: 99%

Role of the Intermediate Filament Protein Peripherin in Health and Disease

Romanò

Fiore

Bucci

2022

IJMS

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Intermediate filaments are the most heterogeneous class among cytoskeletal elements. While some of them have been well-characterized, little is known about peripherin. Peripherin is a class III intermediate filament protein with a specific expression in the peripheral nervous system. Epigenetic modifications are involved in this cell-type-specific expression. Peripherin has important roles in neurite outgrowth and stability, axonal transport, and axonal myelination. Moreover, peripherin interacts with proteins involved in vesicular trafficking, signal transduction, DNA/RNA processing, protein folding, and mitochondrial metabolism, suggesting a role in all these processes. This review collects information regarding peripherin gene regulation, post-translational modifications, and functions and its involvement in the onset of a number of diseases.

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Section: Peripherin Functionsmentioning

confidence: 99%