Changes in the incidence and prevalence of type 1 and type 2 diabetes among 2 million children and adolescents in Hungary between 2001 and 2016 – a nationwide population-based study

Abstract

The aim of the present study was to assess changes in the incidence and prevalence of type 1 diabetes (T1DM) and type 2 diabetes (T2DM) in children and adolescents in Hungary during the period 2001 to 2016 in order to provide nationwide population-based epidemiology data on diabetes in youths aged 0-18 years. Material and methods: This was a retrospective cohort study of Hungarian children and adolescents aged 18 years or younger. Pharmacologically treated diabetes cases were obtained through a population-based registry of the Hungarian National Health Insurance Fund. Time series analysis was used to evaluate the changing patterns of the incidence and prevalence for type 1 and type 2 diabetes covering a 16-year period. Results: During the study period, 6,138 and 1,997 new T1DM and T2DM cases were observed, respectively. Newly diagnosed T2DM cases accounted for 24.5% of all incident diabetes cases. Incidence of T1DM increased from 16/100,000 to 23/100,000 (R 2 = 0.7681; p < 0.0001). The male-to-female ratio among newly diagnosed T1DM patients did not change over the study period. Prevalence of T1DM rose from 114/100,000 to 209/100,000 (R 2 = 0.9909; p < 0.0001). The prevalent T1DM cases showed significant male predominance in every year (p < 0.05). Incidence of T2DM decreased from 8/100,000 to 5/100,000 (R 2 = 0.4977; p < 0.0014). The overall prevalence of T2DM did not change significantly. Prevalent T2DM cases showed significant female predominance in every year (p < 0.0001). A significant decrease in male-to female ratio was observed among newly diagnosed T2DM cases over the study period (p < 0.0001). Conclusions: According to these population-based Hungarian data of children and adolescents with diabetes, T1DM is still the most common form and its frequency continues to rise, affecting more males than females. A high proportion of patients have T2DM, affecting more females than Arch Med Sci 1, December / 2019 35 males, but the occurrence of medically treated cases is not increasing. The decrease in male-to-female ratio in newly diagnosed T2DM cases needs further investigations.

Impact of Genetic Factors on the Age of Onset for Type 2 Diabetes Mellitus in Addition to the Conventional Risk Factors

“…In Hungary, according to the 2019 International Diabetic Federation report, the age-adjusted comparative prevalence of diabetes (type 1 and 2) among the adult population (aged between 20–70 years) is 6.9%, more than 90% of which is accounted for by T2DM [ 32 ]. A recent nationwide population-based study showed that the prevalence of T2DM among children and adolescents in Hungary was 22 out of 100,000 [ 33 ] and this data was higher than in most European countries (such as Denmark [ 34 ] and Germany [ 35 ]). The prevalence of obesity among children or adolescents was 6.6% [ 36 ], while among adults (above 18 years) it was 32% [ 37 ].…”

Egészségügyi szakmai irányelv : A diabetes mellitus kórismézéséről, a cukorbetegek antihyperglykaemiás kezeléséről és gondozásáról felnőttkorban

“…24 Ezzel összefüggésben új, korábban nem észlelt diabetestípus, a gyermek-és ifjúkori 2-es típusú cukorbetegség észlelése már hazánkban sem számít ritkaságnak. 25,26 Említésre érdemes, hogy 2019-ben tudósítottak először arról az IDF kongresszusán, hogy a világ egyes régióiban (néhány fejlett országban) a 2-es típusú diabetes incidenciacsökkenését lehetett megfigyelni az utóbbi években. A hazai adatbáziselemzés eredményei ezzel összhangban állnak.…”

The effect of beinaglutide on visceral fat and bodyweight in obese type 2 diabetic patients

“…Adult weight gain has been associated more with visceral adipose tissue in middle age rather than abdominal subcutaneous adipose tissue [4]. Visceral abdominal adipose tissue is associated with complications of hypertension and cardiovascular risk indicators, especially in younger patients and patients with mild-to-moderate hypertension [5,6].…”