Changes in the Level of Endothelin-1 with Aging.

Komatsumoto, Satoru; Nara, Masaharu

doi:10.3143/geriatrics.32.664

Cited by 39 publications

(25 citation statements)

References 13 publications

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“…It should be emphasised that in our pilot study the patients and controls were not matched for sex and age. In a study on healthy individuals the authors found higher ET-1 levels in older subjects [17]. Therefore, even if we did not confirm the results of the previous studies and found a similar concentration of ET-1 in peripheral blood in MS patients and healthy controls, perhaps a better designed study, with perfectly matched controls, would show a different result.…”

Section: Endothelin-1 Concentrations In Peripheral Jugular and Azygcontrasting

confidence: 56%

Endothelin-1 concentrations in the internal jugular and azygous veins in multiple sclerosis patients: the results of a pilot study

Simka¹,

Ludyga²,

Janas³

et al. 2014

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Objectives: In this pilot study we examined the potent vasoconstrictor, endothelin-1, in the blood of multiple sclerosis patients in the context of chronic cerebrospinal venous insufficiency hypothesis. For this purpose we measured endothelin-1 concentrations in blood samples that were obtained during selective catheterisation of the main veins draining the central nervous system: the internal jugular veins and the azygous vein. Material and methods:We measured endothelin-1 concentrations in peripheral blood in nine multiple sclerosis patients and five healthy controls. In multiple sclerosis patients this peptide was also evaluated in blood samples obtained from the internal jugular veins and azygous vein. Also, in five patients peripheral endothelin-1 levels were measured one and seven days after angioplasty for stenosed internal jugular veins. Results: We found similar concentrations of endothelin-1 in peripheral blood in multiple sclerosis patients and healthy controls, a higher endothelin-1 level in the upper part of right internal jugular veins, and unchanged concentrations of this peptide in peripheral blood following angioplasty. Conclusions: Considering the pilot nature of our trial and the small number of the patients and controls assessed, our findings should be interpreted with caution, but they may represent a useful framework for further research in this field. However, our study shows that it is unlikely that endothelin-1 circulating in the blood is responsible for the symptoms of multiple sclerosis.

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Section: Endothelin-1 Concentrations In Peripheral Jugular and Azygcontrasting

confidence: 56%

Endothelin-1 concentrations in the internal jugular and azygous veins in multiple sclerosis patients: the results of a pilot study

Simka¹,

Ludyga²,

Janas³

et al. 2014

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“…Other possible causes for hypertension are increased endothelin levels, oxidative stress, obesity and stimulation of the sympathetic nervous system (32). Whether administered chronically, endothelin causes increases in sodium reabsorption in the kidney and consequent increase in blood pressure (33), and in postmenopausal women, plasma endothelin levels are increased (34), suggesting that endothelin can play a part in increasing blood pressure after menopause (35). In conclusion, both endothelin and angiotensin II may contribute to oxidative stress (36).…”

Section: Metabolic Syndrome In Menopausal Womenmentioning

confidence: 99%

Prevalence of metabolic syndrome in pre- and postmenopausal women

Marchi

Dell’Agnolo

Lopes

et al. 2017

Arch. Endocrinol. Metab.

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Objective: The objective of this study was to determine the prevalence of metabolic syndrome (MS) and its components among pre-and postmenopausal women, as well as the association between menopausal status and MS. Materials and methods: A retrospective study was conducted at a reference cardiology outpatient clinic in a city located in Northwestern Paraná State, Brazil. A total of 958 medical records of symptomatic climacteric women evaluated between 2010 and 2014 were analyzed. The study consisted of two groups: pre-and post-menopausal women. MS was characterized according to the criteria of the National Cholesterol Education Program's Adult Treatment Panel III -NCEP-ATP III-2005. Results: MS was observed in 18.5% of the total study population; 9.4% of the premenopausal women and 22.2% of the postmenopausal women displayed MS, corresponding to a relative risk of 2.75. In addition, the frequency of MS increased with age. Regarding the components of MS, postmenopausal women were more likely to have high density lipoprotein (HDL-C) levels < 50 mg/dL; systolic blood pressure (SBP) values ≥ 130 mmHg or diastolic blood pressure (DBP) values ≥ 85 mmHg; and fasting glucose levels ≥ 100 mg/dL. Conclusion: MS was more prevalent among postmenopausal women than among premenopausal women. Arch Endocrinol Metab. 2017;61(2):160-6.

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“…41 In postmenopausal women, plasma endothelin levels have been shown to be increased. 42 In PMR, preproendothelin mRNA levels in the kidney are also increased compared with premenopausal female SHR (Yanes et al, unpublished data, 2003 …”

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confidence: 99%

Novel Mechanisms Responsible for Postmenopausal Hypertension

2004

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Abstract-Blood pressure increases in many women after menopause. Hypertension is one of the major risk factors for cardiovascular disease. However, the mechanisms responsible for the postmenopausal increase in blood pressure are yet to be elucidated. Various humoral systems have been proposed to play a role in postmenopausal hypertension, such as changes in estrogen/androgen ratios, increases in endothelin and oxidative stress, and activation of the renin-angiotensin system (RAS). In addition, obesity, type II diabetes, and activation of the sympathetic nervous system are common in postmenopausal women and may also play important roles. However, progress in elucidating the mechanisms responsible for postmenopausal hypertension has been hampered by the lack of a suitable animal model. The aging female spontaneously hypertensive rat (SHR) exhibits many of the characteristics found in postmenopausal women. In this review, some of the possible mechanisms that could play a role in postmenopausal hypertension are discussed, as well as the characteristics of the aged female SHR as a model to study. Key Words: endothelin Ⅲ renin-angiotensin system Ⅲ oxidative stress Ⅲ obesity Ⅲ diabetes mellitus Ⅲ sympathetic nervous system B efore menopause, blood pressure is typically lower in women than in age-matched men. 1 In aging men and women, systolic and diastolic blood pressures increase, although in later years the diastolic plateaus or even declines. [1][2][3] However, in postmenopausal women, the prevalence of hypertension and cardiovascular disease risk increases regardless of ethnic origin. Results from the National Health and Nutrition Examination Survey (NHANES III) showed that in Hispanic women and non-Hispanic black women, the prevalence of hypertension was similar to, or higher than, that in men by age 60 years. 4 In non-Hispanic white populations, the prevalence of hypertension was higher in women than in men by age 70 years. 4 The increase in blood pressure in postmenopausal women does not occur as soon as the ovary becomes senescent, but rather over a number of years. 5 The mechanisms responsible for the increased blood pressure in women after menopause are not known. This review focuses on the use of the spontaneously hypertensive rat as a model of postmenopausal hypertension and evaluates the possible mechanistic roles of the sex hormones, oxidative stress, endothelin, renin-angiotensin system (RAS), weight gain, and sympathetic activation in postmenopausal hypertension. Animal Model for the Study of Postmenopausal HypertensionThe elucidation of mechanisms responsible for postmenopausal hypertension has been stunted by lack of an animal model. Sheep, rabbits, nonhuman primates, rats, and mice have been used as models of various menopausal changes; 6 however, to our knowledge, there is no animal model of naturally occurring postmenopausal hypertension. There have been attempts to mimic menopause by ovariectomizing animals; 7,8 however, these have rarely taken into account the effect of aging and cessation of ova...

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Changes in the Level of Endothelin-1 with Aging.

Cited by 39 publications

References 13 publications

Endothelin-1 concentrations in the internal jugular and azygous veins in multiple sclerosis patients: the results of a pilot study

Endothelin-1 concentrations in the internal jugular and azygous veins in multiple sclerosis patients: the results of a pilot study

Prevalence of metabolic syndrome in pre- and postmenopausal women

Novel Mechanisms Responsible for Postmenopausal Hypertension

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