Changes in the Lung Lipids of Rabbits and Guinea-pigs Exposed to the Inhalation of Silica Dust

Marks, G. S.; Marasas, L. W.

doi:10.1136/oem.17.1.31

Cited by 13 publications

(6 citation statements)

References 12 publications

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“…The increase in total fat accounts for only about 23 % of the total increase in dry weight of the lung. This is in general agreement with the findings of Marks and Marasas (1960), whose figures indicate a value of about 22 %.…”

Section: Resultssupporting

confidence: 93%

Changes in Activities of Respiratory Enzymes in Lungs of Guinea-Pigs Exposed to Silica Dust

Kilroe-Smith¹,

Breyer²

1963

Occupational and Environmental Medicine

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Changes in enzyme activity due to in vivo dusting with quartz were investigated in guinea-pig lungs before the formation of collagen. Of the three enzymes investigated, succindehydrogenase and succinoxidase are increased, and cytochrome c oxidase is not affected by inhalation of quartz dust. The increases tend to reach a maximum which is more rapidly approached by succindehydrogenase than by succinoxidase. The results are discussed in relation to results obtained by other workers on the in vitro effects of silicon compounds. The lung weight increased markedly with increased period of inhalation of dust. This increase is discussed in relation to fat and ash content.

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Section: Resultssupporting

confidence: 93%

Changes in Activities of Respiratory Enzymes in Lungs of Guinea-Pigs Exposed to Silica Dust

Kilroe-Smith¹,

Breyer²

1963

Occupational and Environmental Medicine

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“…The results reported here on rats are similar to those described by Baily et al (1963) and Marks and Marasas (1960) on guinea-pigs after intratracheal injection of quartz. The increase of total phospholipids is caused not only by the increase of phosphatidylcholine but of all the fractions of phospholipids which have been estimated, based on phosphate analysis.…”

Section: Discussionsupporting

confidence: 90%

“…The increase in lung lipids after quartz dust inhalation has been studied in rabbits and guinea-pigs by Fallon (1937), Marks and Marasas (1960), and Baily, Kilroe-Smith, and Harington (1963). These investigations referred to the total lipid content of the lung.…”

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confidence: 99%

Effect of silica on phospholipids in the rat lung

Grunspan¹,

Antweiler²,

Dehnen³

1973

Occupational and Environmental Medicine

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Grunspan, M., Antweiler, H., and Dehnen, W. (1973). British Journal of Industrial Medicine, 30,74-77. Effect of silica on phospholipids in the rat lung. The total amount of phospholipids and the contents of sphingomyelin, phosphatidylcholine, phosphatidylserine, and phosphatidylethanolamine have been estimated in the lungs of rats from 2 to 90 days after intratracheal injections of quartz and corundum, respectively. A significant increase in the contents of lung total phospholipids and of all phospholipid fractions examined was caused by quartz. The first increase was noted 48 hours after quartz application; after 30 days the amount of phosphatidylcholine had increased to about 20-fold, whereas the other phospholipid fractions had reached only an amount two or three times as great as in the control animals. The increase observed was steady for up to 90 days at the end of these experiments.The increase in lung phospholipids was far less when corundum was injected into the lungs.The increase in lung lipids after quartz dust inhalation has been studied in rabbits and guinea-pigs by Fallon (1937), Marks and Marasas (1960), and Baily, Kilroe-Smith, and Harington (1963 Recently we reported changes in the phospholipid content of the lungs of rats after intratracheal injection of quartz (Gruinspan and Antweiler, 1970). In these studies it has been established that quantitative and qualitative changes in lung lipid composition take place during experimental silicosis.In the present study the total amount and the composition of phospholipids in the lungs of normal and quartz-treated rats were analysed at various intervals from 2 to 90 days after quartz application; corundum served for comparison as a non-fibrogenic inert dust. Materials and methodsAdult female wistar rats (Firma Iwanowas), weighing 180 to 200 g, were used for these experiments. They were maintained on a commercial standard diet.Three groups of animals were injected intratracheally as follows: (a) 0 5 ml NaCl 0 9 % (controls): 60 rats (b) 20 mg quartz suspended in 0 5 ml NaCI 0 9 Y.: 220 rats (c) 20 mg corundum suspended in 0O5 ml NaCl 0 9 %: 30 rats. The maximum particle size of quartz and corundum (Dorentrup No. 12) was 3 FLm. The specific quartz surface amounted to 9-1 m2/g and that of corundum to 5.34 m2/g. Preparation of dust suspensions Quartz or corundum, 1 g, was mixed with 25 ml 0 9 % 74 on 7 April 2019 by guest. Protected by copyright.

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“…With respect to the content and distribution of pulmonal lipids, Fallon [ 11, Katznelson [ 181, Babushina and Katznelson [19], and Hernandez Quero [20], have shown in different animals that in severe experimental pneumoconiosis there is an increase in lung total lipids at the expense of the phospholipids. Furthermore, Marks and Marasas [21], Baily [22], and Heppelton [23] have shown by means of TLC of lung lipids extracts that the increase in phospholipids is mainly due to increased lecithin and lysolecithin fractions.…”

Section: Discussionmentioning

confidence: 99%

Rabbit lung lipids in experimental fibrosis and emphysema: lipolytic activity and content and distribution of lipids

Rosario

González-Santos

1983

Eur J Clin Investigation

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Changes in the Lung Lipids of Rabbits and Guinea-pigs Exposed to the Inhalation of Silica Dust

Cited by 13 publications

References 12 publications

Changes in Activities of Respiratory Enzymes in Lungs of Guinea-Pigs Exposed to Silica Dust

Changes in Activities of Respiratory Enzymes in Lungs of Guinea-Pigs Exposed to Silica Dust

Effect of silica on phospholipids in the rat lung

Rabbit lung lipids in experimental fibrosis and emphysema: lipolytic activity and content and distribution of lipids

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