Changes in the lymphocyte subsets during high dose immunoglobulin therapy for intractable childhood epilepsy

What are the effects of intravenous immunoglobulins on seizures and quality of life of people with epilepsy? A Cochrane Review summary with commentary

“…Epilepsy is a common neurological condition, with an estimated incidence of 50 per 100 000 overall and a prevalence of 5 to 10 per 1000 in the developed world. 2 Epilepsy has been associated with immune system dysfunction, including low serum IgA levels, lack of the IgG subclass, 3,4 and presence of antibodies, often related to the primary disease. [5][6][7] This brought the notion that immunoglobulin-based therapy could be a treatment option for epilepsy.…”