Changes in the Macular Ganglion Cell Complex Thickness and Central Macular Thickness after Argon Laser Panretinal Photocoagulation

Demirok, Gülizar; Kocamaz, Mehmet Fatih; Topalak, Yasemin; Altay, Yeşim; Tabakçı, Burcu Nurözler; Şengün, Ahmet

doi:10.1080/08820538.2016.1177098

Cited by 4 publications

(3 citation statements)

References 18 publications

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“…Over the long-term followup, they gradually returned to the baseline level. Many of the previous studies using OCT obtained similar results (27,28). They considered that the retinal inflammation and edema caused by PRP at the early postoperative phase could damage the retinal neural cell and tissue and later recovery might be attributed to the absorption and healing of the edema and the laser-induced photoreceptors and ganglion cell damage.…”

Section: Discussionmentioning

confidence: 72%

Long-Term Retinal Neurovascular and Choroidal Changes After Panretinal Photocoagulation in Diabetic Retinopathy

Huang

Xie

et al. 2021

Front. Med.

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Purpose: To evaluate the long-term retinal microvascular, neural, and choroidal changes in the patients with severe nonproliferative diabetic retinopathy (NPDR) and proliferative diabetic retinopathy (PDR) following panretinal photocoagulation (PRP).Methods: Forty-five eyes of 28 patients with treatment-naive severe NPDR and PDR were included and followed for 12 months after PRP. Microvascular and neural changes in the macular and peripapillary areas were assessed by using optical coherence tomography angiography. Subfoveal choroidal thickness (SFCT) was measured by using optical coherence tomography. A Linear mixed-effects model was used to highlight the differences for the variables after adjusting for sex, age, and axial length.Results: Compared to baseline, there were no statistical differences in the best corrected visual acuity (BCVA), macular and peripapillary vessel density (VD), and SFCT following PRP. Macular thickness significantly increased at 1 and 3–6 months after PRP (p < 0.05), while the peripapillary retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) thickness significantly increased at 1 month postoperatively (p < 0.01). Global loss volume and focal loss volume significantly decreased at the same time point (p < 0.05).Conclusion: The unchanged BCVA, VD, the thickness of RNFL and GCC, and SFCT during the 12-month follow-up period suggest that PRP may prevent the retinal neurovascular and choroidal damage.

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Section: Discussionmentioning

confidence: 72%

Long-Term Retinal Neurovascular and Choroidal Changes After Panretinal Photocoagulation in Diabetic Retinopathy

Huang

Xie

et al. 2021

Front. Med.

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“…In argon laser photocoagulation, the laser energy is absorbed by the retinal pigment epithelium (RPE) and generates thermal energy to the outer retina. Heat damage in the inner retinal layers causes edema due to increased vascular permeability and presents as increased retinal thickness 20 . As expected, the authors observed a mild increase in macular thickness during the 12 months post PRP.…”

Section: Discussionmentioning

confidence: 99%

Longitudinal changes in retinal microvasculature after panretinal photocoagulation in diabetic retinopathy using swept-source OCT angiography

Kim

2021

Sci Rep

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This study evaluated quantitative changes in microvascular parameters after panretinal photocoagulation (PRP) in diabetic retinopathy (DR), using swept-source OCT Angiography (SS-OCTA). A total of 27 treatment-naïve eyes were subjected to PRP and followed-up for > 12 months after the procedure. Foveal avascular zone (FAZ) area, macular perfusion density (PD), and vessel length density (VLD) were calculated on a 3 × 3 mm en face OCTA image and nonperfusion area (NPA) was obtained on a 12 × 12 mm en face OCTA image. One month after PRP, PD and VLD of superficial and deep capillary plexus decreased and subsequently, increased progressively across the next 12 months, with statistically significant differences (P = 0.015 and 0.02). Continuous decreasing trends in total NPA values was observed across 12 months after PRP (P = 0.125). A difference in PD of the superficial capillary plexus between baseline and 6 months post PRP, was significantly associated with the progression of DR, 12 months after PRP (OR 0.528; P = 0.025). We found significant longitudinal retinal microvascular changes after PRP in DR. Overall macular perfusion status was impaired and progressively recovered across the next 12 months, compared to the baseline. Additionally, the early treatment responses in PD can predict the long-term outcomes of PDR after PRP.

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“…The macular region retinal nerve fiber layer was reported to increase in the short-term [15] due to axonal edema but decrease thereafter since standard PRP with Argon laser [16]. The increased vascular permeability in the superficial vascular plexus associated to heat damage was reported to increase the thickness of the macular ganglion cell complex in the initial months, with subsequent return to baseline values at 12 months in one study [17] but not in another one [18]. According to the authors' knowledge, this is the first study reporting measurements on these retinal layers on a long-term basis.…”

Section: Discussionmentioning

confidence: 97%

Long-Term Structural Effects of Retinal Photocoagulation in Diabetic Retinopathy

Baptista¹,

Marta²,

Heitor³

et al. 2021

Act Sci Oph

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Background and Objective: Pan-retinal photocoagulation (PRP) have potential structural deleterious effects in retinal and choroidal tissues. To assess the long-term retinal and choroidal status after PRP and to correlate the results with treatment strategies. Design/Materials and Methods:Observational cross-sectional study including eyes with diabetic retinopathy who underwent PRP, with or without macular treatments.Results: 227 eyes with a mean time since PRP of 10.0 ± 7.2 years. In a multivariable model, the only treatment characteristics with predictive value were the macular laser treatment with modified grid for worse BCVA, the higher number of laser spots for higher CT and GCLV and the laser treatment with Argon for lower FNFLT. Conclusion:This study demonstrates long-term stability in the BCVA and choroidal and retinal structural parameters with only mild correlation with treatment strategies, highlighting the role of PRP in the management of diabetic retinopathy in an era with evolving less aggressive laser options.

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Changes in the Macular Ganglion Cell Complex Thickness and Central Macular Thickness after Argon Laser Panretinal Photocoagulation

Abstract: GCC thickness increased significantly until month 6 compared with baseline values in most of the macular segments post-PRP in the PDR group. The GCC thickness at month 12 was not different from the baseline thickness in any of the macular segments.

Cited by 4 publications

References 18 publications

Long-Term Retinal Neurovascular and Choroidal Changes After Panretinal Photocoagulation in Diabetic Retinopathy

Long-Term Retinal Neurovascular and Choroidal Changes After Panretinal Photocoagulation in Diabetic Retinopathy

Longitudinal changes in retinal microvasculature after panretinal photocoagulation in diabetic retinopathy using swept-source OCT angiography

Long-Term Structural Effects of Retinal Photocoagulation in Diabetic Retinopathy

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