Changes in the mechanical properties of human coronary arteries with age

Purinya, B. A.; Kasyanov, Vladimir

doi:10.1007/bf00859594

Cited by 10 publications

(3 citation statements)

References 8 publications

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“…[22][23][24][25][26] The work of Hayashi et al and that of one of the present authors (V.A.K.) and his associates [28][29][30] shed some light on the properties of human blood vessels; however, more insight is needed on the structure and properties of arteries before small diameter grafts with maximum potential success can be engineered.…”

Section: Introductionmentioning

confidence: 86%

Biomechanics of human common carotid artery and design of novel hybrid textile compliant vascular grafts

Gupta

Kasyanov

1997

J. Biomed. Mater. Res.

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The mechanical properties and structure of a human common carotid artery were studied in order to develop criteria for designing and manufacturing compliant textile vascular grafts. The arterial wall comprised a composite of elastin and collagen fibers with the collagen fibers crimped. This structure led to a unique pressure-circumferential stretch ratio curve, the slope of which increased with an increase in strain. The increase in slope was particularly rapid at a stretch ratio above 1.4 or pressure above 120 mmHg. Based on the knowledge gained, a criteria for the design of biomechanically compliant arterial grafts was developed. An elastomeric prestretched polyurethane monofilament yarn with a low modulus of elasticity and a bulked polyester multifilament yarn with a high modulus of elasticity were combined and used as threads in the manufacture of grafts. Tubular structures of diameters in the range 4-6 mm were made by weaving. Transverse compliance and morphological and permeability properties of these grafts were determined and compared with those of a currently available woven commercial grafts and human carotid arteries. Results indicated that the compliance values of the hybrid grafts were comparable with those of the human carotid artery. Preliminary in vivo studies in dogs showed promising results: a thin, stable neointima developed within 6 months of implantation on the flow surface.

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Section: Introductionmentioning

confidence: 86%

Biomechanics of human common carotid artery and design of novel hybrid textile compliant vascular grafts

Gupta

Kasyanov

1997

J. Biomed. Mater. Res.

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“…Eighteen cadaveric human CCA specimens (mean age 69 ± 8) approximately 5 cm long and free of gross pathology were harvested within six hours of death using rapid autopsy technique [23][24][25]. EJVs and GSVs were obtained fresh as leftover materials after carotid endarterectomy.…”

Section: Methodsmentioning

confidence: 99%

Comparative Analysis of the Biaxial Mechanical Behavior of Carotid Wall Tissue and Biological and Synthetic Materials Used for Carotid Patch Angioplasty

Kamenskiy

Pipinos

MacTaggart

et al. 2011

Journal of Biomechanical Engineering

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Patch angioplasty is the most common technique used for the performance of carotid endarterectomy. A large number of patching materials are available for use while new materials are being continuously developed. Surprisingly little is known about the mechanical properties of these materials and how these properties compare with those of the carotid artery wall. Mismatch of the mechanical properties can produce mechanical and hemodynamic effects that may compromise the long-term patency of the endarterectomized arterial segment. The aim of this paper was to systematically evaluate and compare the biaxial mechanical behavior of the most commonly used patching materials. We compared PTFE (n = 1), Dacron (n = 2), bovine pericardium (n = 10), autogenous greater saphenous vein (n = 10), and autogenous external jugular vein (n = 9) with the wall of the common carotid artery (n = 18). All patching materials were found to be significantly stiffer than the carotid wall in both the longitudinal and circumferential directions. Synthetic patches demonstrated the most mismatch in stiffness values and vein patches the least mismatch in stiffness values compared to those of the native carotid artery. All biological materials, including the carotid artery, demonstrated substantial nonlinearity, anisotropy, and variability; however, the behavior of biological and biologically-derived patches was both qualitatively and quantitatively different from the behavior of the carotid wall. The majority of carotid arteries tested were stiffer in the circumferential direction, while the opposite anisotropy was observed for all types of vein patches and bovine pericardium. The rates of increase in the nonlinear stiffness over the physiological stress range were also different for the carotid and patching materials. Several carotid wall samples exhibited reverse anisotropy compared to the average behavior of the carotid tissue. A similar characteristic was observed for two of 19 vein patches. The obtained results quantify, for the first time, significant mechanical dissimilarity of the currently available patching materials and the carotid artery. The results can be used as guidance for designing more efficient patches with mechanical properties resembling those of the carotid wall. The presented systematic comparative mechanical analysis of the existing patching materials provides valuable information for patch selection in the daily practice of carotid surgery and can be used in future clinical studies comparing the efficacy of different patches in the performance of carotid endarterectomy.

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“…However, human and animal experiments demonstrate that cadaveric arterial tissues obtained with rapid autopsy techniques maintain the mechanical properties of the arteries in vivo and therefore they are the tissues of choice for modeling of human carotid mechanical properties. [14][15][16] Mechanical properties of the PTFE patch (Accuseal cardiovascular patch; WL Gore & Associates, Flagstaff, Arizona) were determined with similar uniaxial extension technique and loading range on MicroTest 200 (Gatan Inc, Warrendale, Pennsylvania) uniaxial tensile device.…”

Section: Evaluation Of the Mechanical Properties Of Cadaveric Common Carotids And Ptfe Patchmentioning

confidence: 99%

Finite Element Model of the Patched Human Carotid

Kamenskiy

Pipinos

Desyatova

et al. 2009

Vasc Endovascular Surg

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Changes in the mechanical properties of human coronary arteries with age

Cited by 10 publications

References 8 publications

Biomechanics of human common carotid artery and design of novel hybrid textile compliant vascular grafts

Biomechanics of human common carotid artery and design of novel hybrid textile compliant vascular grafts

Comparative Analysis of the Biaxial Mechanical Behavior of Carotid Wall Tissue and Biological and Synthetic Materials Used for Carotid Patch Angioplasty

Finite Element Model of the Patched Human Carotid

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