Changes in the planning target volume and liver volume dose based on the selected respiratory phase in respiratory-gated radiation therapy for a hepatocellular carcinoma

Lee, Jae Seung; Im, Inchul; Kang, Su-Man; Goo, Eun-Hoe; Baek, Seong-Min

doi:10.3938/jkps.63.1832

Cited by 1 publication

(2 citation statements)

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“…Although it is not clear which dose-volume parameters can effectively reduce the induced liver organ damage, the main causes of radiation complications are due to RT [4]. Although most RIHT cases can be controlled through treatment, this complication can lead to worsened liver function and severe damage and lead to liver failure and death [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

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Risk Prediction of Radiation-Induced Hepatic Toxicity Complications in Patients With Hepatocellular Carcinoma

Shieh¹,

Chou²,

Huang³

et al. 2020

Preprint

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We use dose-volume factors to predict the risk of radiation-induced hepatic toxicity (RIHT) complications in patients with hepatocellular carcinoma (HCC) for controlling the low tolerance of liver organs to radiation and reducing the incidence of radiation-induced hepatic toxicity complications. This study retrospectively collected 114 patients who underwent Intensity Modulation Radiation Therapy (IMRT) for hepatocellular carcinoma between 2014 and 2017. The total number of patients was 69 after excluding normal liver organs whose volume did not reach 700 cc and extreme data. A total of 138 experimental samples were generated using the bootstrap method. All patients were evaluated using the Common Terminology Criteria for Adverse Events (CTCAE) during treatment to determine the degree of increase in blood draws and to judge for radiation-induced hepatic toxicity complications. The patient received dose-volume parameters were uniformly adjusted using a bioequivalent dose conversion of 2 Gy/fraction. The study data were divided into normal and total liver received dose-volume. Least absolute shrinkage and selection operator (LASSO) was used to select predictors and logistic regression (LR) was used to establish the performance model. LASSO was used to select the patient dose-volume parameter predictor. The risk factors of normal liver received dose-volume were age and NLV30 Gy. The risk factors of total liver received dose-volume were age and TLV35 Gy. For patients with hepatocellular carcinoma receiving radiation therapy (RT), this study recommends that a normal liver receiving a dose volume of 30 Gy should be less than 54.75%, so that the probability of RIHT can be less than 50%. A total liver receiving a dose volume of 35 Gy should be less than 54.75% so that the probability of RIHT can be less than 50%. It can control the low tolerance of liver organs to radiation and reduce the incidence of hepatotoxic complications induced by radiotherapy techniques.

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Section: Introductionmentioning

confidence: 99%

“…It is important to not only maximize the effective dose to the tumor but also to minimize the dose delivered to the surrounding normal liver. Predicting complication risks will be a considerable clinical advantage [6][7][8].…”

Section: Introductionmentioning

confidence: 99%