Changes in the Quantitative and Functional Characteristics of Bacterioplankton under the Influence of Aqueous Unmodified Fullerene С60 Dispersions

Мошарова, И. В.; Dallakyan, G. A.; Mikheev, Ivan V.; Ильинский, В. В.; Akulova, A. Yu.

doi:10.1134/s1607672919040045

Cited by 2 publications

(2 citation statements)

References 6 publications

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“…Despite the apparent advantages of aqueous dispersions of pristine fullerenes, their biochemical properties have been studied exceptionally poorly. AFD stimulated the natural heterotrophic bacterioplankton and inhibited the bactericidal activity of antibiotics [32]. We have shown that AFDs of C60, C70, and C82 are moderate scavengers of superoxide anion radicals [33].…”

Section: Introductionmentioning

confidence: 81%

Effects of Aqueous Dispersions of C60, C70 and Gd@C82 Fullerenes on Genes Involved in Oxidative Stress and Anti-inflammatory Pathways

Проскурнина¹,

Mikheev²,

Savinova³

et al. 2021

Preprint

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Background: Fullerenes and metallofullerenes can be considered promising nanopharmaceuticals themselves and as a basis for chemical modification. As reactive oxygen species homeostasis plays a vital role in cells, the study of their effect on genes involved in oxidative stress and anti-inflammatory response is of particular importance. Methods: Human fetal lung fibroblasts were incubated with aqueous dispersions of C60, C70, and Gd@C82 in concentrations of 5 nM and 1.5 µM for 1, 3, 24, and 72 hours. Cell viability, intracellular ROS, NOX4, NFκB, PRAR-γ, NRF2, heme oxygenase 1, and NAD(P)H quinone dehydrogenase 1 expression have been studied. Results &amp; conclusion: The aqueous dispersions of C60, C70, and Gd@C82 fullerenes are active participants in ROS homeostasis. Low and high concentrations of AFDs have similar effects. C70 was the most inert substance, C60 was the most active substance. All AFDs have both a “prooxidant” and “antioxidant” effect, but with a different balance. Gd@C82 was a substance with more pronounced antioxidant and anti-inflammatory properties, while C70 had more pronounced “prooxidant” properties.

show abstract

Section: Introductionmentioning

confidence: 81%

Effects of Aqueous Dispersions of C60, C70 and Gd@C82 Fullerenes on Genes Involved in Oxidative Stress and Anti-inflammatory Pathways

Проскурнина¹,

Mikheev²,

Savinova³

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…Despite the apparent advantages of aqueous dispersions of pristine fullerenes, their biochemical properties have been studied exceptionally poorly. AFD stimulated the natural heterotrophic bacterioplankton and inhibited the bactericidal activity of antibiotics [ 32 ]. We have shown that AFDs of C 60 , C 70, and C 82 are moderate scavengers of superoxide anion radicals [ 33 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Aqueous Dispersions of C60, C70 and Gd@C82 Fullerenes on Genes Involved in Oxidative Stress and Anti-Inflammatory Pathways

Проскурнина

Mikheev

Savinova

et al. 2021

IJMS

View full text Add to dashboard Cite

Background: Fullerenes and metallofullerenes can be considered promising nanopharmaceuticals themselves and as a basis for chemical modification. As reactive oxygen species homeostasis plays a vital role in cells, the study of their effect on genes involved in oxidative stress and anti-inflammatory responses are of particular importance. Methods: Human fetal lung fibroblasts were incubated with aqueous dispersions of C60, C70, and Gd@C82 in concentrations of 5 nM and 1.5 µM for 1, 3, 24, and 72 h. Cell viability, intracellular ROS, NOX4, NFκB, PRAR-γ, NRF2, heme oxygenase 1, and NAD(P)H quinone dehydrogenase 1 expression have been studied. Results & conclusion: The aqueous dispersions of C60, C70, and Gd@C82 fullerenes are active participants in reactive oxygen species (ROS) homeostasis. Low and high concentrations of aqueous fullerene dispersions (AFD) have similar effects. C70 was the most inert substance, C60 was the most active substance. All AFDs have both “prooxidant” and “antioxidant” effects but with a different balance. Gd@C82 was a substance with more pronounced antioxidant and anti-inflammatory properties, while C70 had more pronounced “prooxidant” properties.

show abstract

Changes in the Quantitative and Functional Characteristics of Bacterioplankton under the Influence of Aqueous Unmodified Fullerene С60 Dispersions

Cited by 2 publications

References 6 publications

Effects of Aqueous Dispersions of C60, C70 and Gd@C82 Fullerenes on Genes Involved in Oxidative Stress and Anti-inflammatory Pathways

Effects of Aqueous Dispersions of C60, C70 and Gd@C82 Fullerenes on Genes Involved in Oxidative Stress and Anti-inflammatory Pathways

Effects of Aqueous Dispersions of C60, C70 and Gd@C82 Fullerenes on Genes Involved in Oxidative Stress and Anti-Inflammatory Pathways

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