Changes in the salivary oxidative status in individuals with temporomandibular disorders and pain

Almeida, Cleibson Aparecido de; Amenábar, José Miguel

doi:10.1016/j.jobcr.2016.10.006

Cited by 19 publications

(22 citation statements)

References 26 publications

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“…The results of our study did not confirm lower levels of salivary TAC in TMD patients as we expected, based on the results of previous studies ( Rodríguez de Sotillo et al, 2011 ; De Almeida and Amenábar, 2016 ). On the contrary, TAC was significantly higher in our TMD patients in comparison with controls.…”

Section: Discussioncontrasting

confidence: 99%

“…Considering that they experienced pain lasting more than 6 months, higher TAC might imply a compensatory increase of the antioxidant enzymes in response to changing levels of OS as a prerequisite for efficient defense ( Sies, 1993 ). De Almeida and Amenábar (2016) did not report how long their patients experienced TMD pain, and it is unclear from the report by Rodríguez de Sotillo et al (2011) whether alltheir patients had chronic pain. With longer duration of the disorder, antioxidant systems might regenerate (if their level was decreased in comparison with healthy subjects) or increase, probably as a compensatory mechanism (as found in our study).…”

Section: Discussionmentioning

confidence: 98%

“… Rodríguez de Sotillo et al (2011) reported increased OS products in TMD patients and a significant association between TMD pain and salivary OS markers. De Almeida and Amenábar (2016) determined lower total antioxidant capacity (TAC) in patients with pain-related TMD, but they found no correlation between TAC and pain intensity. Basi et al (2012) as well as Etöz et al (2012) support the role of OS in the intensity of pain in TMD but specimen other than saliva were used in these studies.…”

Section: Introductionmentioning

confidence: 99%

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Salivary Oxidant/Antioxidant Status in Chronic Temporomandibular Disorders Is Dependent on Source and Intensity of Pain – A Pilot Study

et al. 2018

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Temporomandibular disorders (TMD) have been associated with altered salivary oxidative status, but the relation with pain source and pain severity isn’t clarified. With the aim to assess their interaction with TMD, we compared levels of selected salivary oxidative stress (OS) markers (glutathione peroxidase, superoxide dismutase, total antioxidant capacity (TAC), uric acid, 8-hydroxydeoxyguanosine, malondialdehyde) and salivary cortisol (SC) as a stress indicator, between 20 TMD patients and 15 healthy control subjects. In order to record differences relating to pain source and severity, patients were respectively classified according to specific diagnoses (myofascial pain or disc displacement (DD)), and pain intensity (high or low). TAC was significantly higher in TMD patients than in controls (morning p = 0.015; afternoon p = 0.005). Significant differences were also observed when TAC levels between high-intensity pain patients and controls were compared, as well as between DD patients and controls. In logistic regression analysis, higher levels of TAC were related to DD (morning OR: 1.66, 95%CI: 1.05–2.64, p = 0.029; afternoon OR: 2.10, 95%CI: 1.11–3.98, p = 0.021) and to high-intensity pain (morning OR: 1.81, 95%CI: 1.04–3.15, p = 0.037; afternoon OR: 1.79, 95%CI: 1.02–3.14, p = 0.043). We also found that morning SC was positively correlated with antioxidant parameters in TMD patients. Our data suggest compensatory mechanism as response to higher level of stress. This stress could be extrinsic and lead toward TMD, or intrinsic, emerging from established TMD, or could be both. The intensity and the source of pain should be considered important factors in future investigations evaluating salivary OS markers in TMD patients.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

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Salivary Oxidant/Antioxidant Status in Chronic Temporomandibular Disorders Is Dependent on Source and Intensity of Pain – A Pilot Study

et al. 2018

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“…Oxidative changes seem to influence the pathogenesis of pain in TMD. 15 Previous studies have confirmed that the reduction of TAC in patients with acute pain or inflammation. [20][21][22] In TMD, trauma, mechanical stress, disc disorders and destructive changes can trigger the release of free radicals leading to osteoarthritis (OA) and oxidant/antioxidant imbalance.…”

Section: Total Antioxidant Capacity (Tac)mentioning

confidence: 85%

“…1,2,4,8 Recently synovial fluid, saliva and blood can be used as the diagnostic marker for TMD. 9,10,10- 15 The biomarkers can also be useful to detect early TMD. TMJ synovial fluid can be collected from patients undergoing arthroscopy or arthrotomy surgery.…”

Section: Introductionmentioning

confidence: 99%

Biomarkers of Temporomandibular Disorders

Dominica¹,

Naliani²,

Lelyana³

et al. 2019

sod

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Temporomandibular disorder is a disorder that includes masticatory muscles or temporomandibular joints, unbalanced joint function or both. The disorders can disturb daily activity, cause by pain. The therapy consuming time and cost. Early detection of temporomandibular disorder is needed, as a prevention of more severe disorders. Increased cortisol can be found in myofacial pain and is not found in internal dearagement or osteoarthritis. Biomarkers of interleukin and monocyte chemoattractant proteins are only found in osteoarthritis. The use of biomarkers can be useful in detecting temporomandibular disorders. Biomarkers can be measured from blood, serum and saliva. Cortisol, dopamine and TAC are potential biomarkers in the temporomandibular disorder.

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Salivary Bioscience and Pain

Payne

Fortier

2020

Salivary Bioscience

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Changes in the salivary oxidative status in individuals with temporomandibular disorders and pain

Cited by 19 publications

References 26 publications

Salivary Oxidant/Antioxidant Status in Chronic Temporomandibular Disorders Is Dependent on Source and Intensity of Pain – A Pilot Study

Salivary Oxidant/Antioxidant Status in Chronic Temporomandibular Disorders Is Dependent on Source and Intensity of Pain – A Pilot Study

Biomarkers of Temporomandibular Disorders

Salivary Bioscience and Pain

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