Changes in the serotonin and 5-hydroxyindoleacetic acid contents in rat brain after ethanol and disulfiram treatments

Fukumori, Ryuji; Minegishi, Akemi; Satoh, Tetsuo; Kitagawa, Haruo; Yanaura, Saiζo

doi:10.1016/0014-2999(80)90166-1

Cited by 25 publications

(8 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This supports our hypotheses that we developed since disulfiram raises serotonin levels (Fukumori et al , 1979, Fukumori et al , 1980, Nagendra et al , 1993, Nilsson & Tottmar, 1989). Subjects with at least one copy of the 5-HTTLPR S′ allele or at least one TPH2 A allele had decreased cocaine positive urines compared to those without these alleles.…”

Section: Discussionsupporting

confidence: 89%

“…This supports our hypotheses that we developed since disulfiram raises serotonin levels (Fukumori et al . ,; Nagendra et al . ; Nilsson & Tottmar ).…”

Section: Discussionmentioning

confidence: 99%

“…Disulfiram treatment increases serotonin’s precursor tryptophan, its metabolite 5-hydroxyindole acetic acid, and the hydroxylated product of tryptophan, 5-hydroxytryptophan (Fukumori et al , 1979, Fukumori et al , 1980, Nagendra et al , 1993, Nilsson & Tottmar, 1989). Since cocaine’s mechanism of action is through blockade of dopamine, norepinephrine, and serotonin transporters (Han & Gu, 2006), it is possible that disulfiram may be effective for the treatment of cocaine dependence, in part, through its action on serotonin.…”

Section: Introductionmentioning

confidence: 99%

“…Disulfiram treatment increases serotonin's precursor tryptophan, its metabolite 5‐hydroxyindole acetic acid and the hydroxylated product of tryptophan, 5‐hydroxytryptophan (Fukumori et al . , ; Nagendra et al . ; Nilsson & Tottmar ).…”

mentioning

confidence: 99%

See 3 more Smart Citations

Modifying the role of serotonergic 5‐HTTLPR and TPH2 variants on disulfiram treatment of cocaine addiction: a preliminary study

Nielsen

Harding

Hamon

et al. 2012

Genes Brain and Behavior

View full text Add to dashboard Cite

Disulfiram is a cocaine pharmacotherapy that may act through increasing serotonin, benefiting patients with genetically low serotonin transporter levels (5-HTTLPR S′ allele carriers) and low serotonin synthesis (TPH2 A allele carriers). We stabilized 71 cocaine and opioid co-dependent patients on methadone for two weeks and randomized them into disulfiram and placebo groups for 10 weeks. We genotyped the SLC6A4 5-HTTLPR (rs4795541, rs25531) and TPH2 1125A>T (rs4290270) variants and evaluated their role in moderating disulfiram treatment for cocaine dependence. Cocaine positive urines dropped from 78% to 54% for the disulfiram group and from 77% to 76% for the placebo group among the 5-HTTLPR S′ allele carriers (F = 16.2; df = 1,301; P <0.0001). TPH2 A allele carriers responded better to disulfiram than placebo (F = 16.0; df = 1,223; P <0.0001). Patients with both an S′ allele and a TPH2 A allele reduced cocaine urines from 71% to 53% on disulfiram and had no change on placebo (F = 21.6; df = 1,185; P <0.00001).

show abstract

Section: Discussionsupporting

confidence: 89%

“…This supports our hypotheses that we developed since disulfiram raises serotonin levels (Fukumori et al . ,; Nagendra et al . ; Nilsson & Tottmar ).…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Modifying the role of serotonergic 5‐HTTLPR and TPH2 variants on disulfiram treatment of cocaine addiction: a preliminary study

Nielsen

Harding

Hamon

et al. 2012

Genes Brain and Behavior

View full text Add to dashboard Cite

show abstract

“…The same study showed that the 5-HTTLPR S′-allele carriers had fewer cocaine-positive urines over the course of the interventional study than did L′L′ homozygous subjects [43]. This suggests that cocaine-dependent S′ carriers respond better to disulfiram [44–46] than L'L' subjects. Neuroimaging findings show that the S′ carriers of the 5-HTT ( SLC6A4 ) gene display abnormalities in functional activation in the amygdala in response to emotional stimuli [47].…”

Section: Cocainementioning

confidence: 99%

Serotonergic Gene Variation in Substance Use Pharmacotherapy: A Systematic Review

et al. 2015

View full text Add to dashboard Cite

Drug addiction is a serious disease with damaging effects on the brain and physical health. Despite the increase in the number of affected individuals, there are few effective pharmacological treatment options for substance use disorders. The study of the influence of an individual's genetic features on the treatment response may help to identify more efficacious treatment options. This systematic review focuses on the serotonergic system because of its relevant role in mood and impulse control disorders, and its contribution to the development and maintenance of drug use disorders. In particular, we examine the role of serotonergic genes in the response to pharmacotherapy for alcohol, cocaine and nicotine addiction. Current evidence suggests that genetic variability of the serotonergic biosynthesis enzyme tryptophan hydroxylase 2 (TPH2) and the serotonin transporter (SLC6A4) genes mediates the efficacy of several addiction treatments, such as ondansetron and disulfiram, and the antidepressants bupropion, nortriptyline and sertraline.

show abstract

Kinetics of Drug Action in Disease States. XLIII: Potentiating Effect of l-Tryptophan on the Hypnotic Action of Phenobarbital and Ethanol in Rats

Wilson

Levy

1994

Journal of Pharmaceutical Sciences

View full text Add to dashboard Cite

Changes in the serotonin and 5-hydroxyindoleacetic acid contents in rat brain after ethanol and disulfiram treatments

Cited by 25 publications

References 9 publications

Modifying the role of serotonergic 5‐HTTLPR and TPH2 variants on disulfiram treatment of cocaine addiction: a preliminary study

Modifying the role of serotonergic 5‐HTTLPR and TPH2 variants on disulfiram treatment of cocaine addiction: a preliminary study

Serotonergic Gene Variation in Substance Use Pharmacotherapy: A Systematic Review

Kinetics of Drug Action in Disease States. XLIII: Potentiating Effect of l-Tryptophan on the Hypnotic Action of Phenobarbital and Ethanol in Rats

Contact Info

Product

Resources

About