Changes in the structure and regeneration mode of the rat small intestinal mucosa following benzalkonium chloride treatment

Holle, G

doi:10.1016/0016-5085(91)90076-w

Cited by 44 publications

(32 citation statements)

References 26 publications

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“…Many researchers observed an increase in villus height, crypt depth, and muscle layer in the denervated segments after application of BAC [15,[18][19][20]. Similarly, we observed many morphologic changes in the treated segments.…”

Section: Discussionsupporting

confidence: 55%

Morphological Alterations in Small Intestine of Rats with Myenteric Plexus Denervation

Deniz

Kilinc²,

Hatipoğlu³

2004

Eur Surg Res

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We aimed to investigate the effect of myenteric denervation by benzalkonium chloride (BAC) on small intestine morphology in the rat, and whether segmental myenteric denervation alters morphology elsewhere in the small intestine. Forty male Sprague-Dawley rats were equally divided into 4 groups: control (0.9% NaCl); denervation (0.062% BAC); chemical inflammation (5% acetic acid), and intraluminal stasis produced by partial obstruction. 28 days after operation tissue samples were taken from the treated segment, 10 cm distal to the treated segment, and 20 cm proximal to the treated segment. Morphological changes and the number of ganglion cells were examined under the light microscope. BAC application reduced the number of myenteric neurons by 85% in the treated segment. Denervation increased villus height and crypt depth in the treated and proximal segments. But changes in muscle thickness were seen throughout the intestine. As a result, although myenteric plexus denervation caused mucosa morphology in the treated and proximal segments, it caused smooth muscle changes throughout the small intestine.

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Section: Discussionsupporting

confidence: 55%

Morphological Alterations in Small Intestine of Rats with Myenteric Plexus Denervation

Deniz

Kilinc²,

Hatipoğlu³

2004

Eur Surg Res

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“…The repercussions of myenteric denervation on epithelial morphology can occur early. Significant hyperplasia of the villi and crypts from the duodenum, jejunum and ileum was seen 7 days after BAC treatment [11]. This author concludes that treatment with BAC influences the proliferation and migration of the epithelial cells in the treated intestinal segment.…”

Section: Discussionmentioning

confidence: 70%

The relationship between myenteric neuronal denervation, smooth muscle thickening and epithelial cell proliferation in the rat colon

et al. 1997

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The effects of myenteric neuronal denervation on smooth muscle thickening and epithelial cell proliferation were studied in the descending colon of rats treated by serosal application of 2 mM benzalkonium chloride (BAC) for 30 min. Control animals were treated with saline (0.9% NaCl). The animals were divided into six groups of 13 animals each and killed 10, 45 and 120 days after BAC treatment. A significant reduction in neuron number was observed in the myenteric plexus of animals treated with BAC, as well as smooth muscle thickening and an increase in crypt cell population, crypt cell production per crypt and a decrease in cell cycle time. These findings permit us to conclude that a relationship may exist between the increase of epithelial cell proliferation, smooth muscle thickening and myenteric neuron denervation in the descending colon caused by BAC, the latter probably playing an important role in the integration of the other two.

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“…The intramural ganglion neurons too undergo hypertrophy (Gabella, 1984), and the altered innervation may exert new trophic effects on the mucosa. The last possibility is suggested by the studies of Holle (1991) and Hadzijahic et al (1993) on the effects of myenteric ganglionectomy on the structure of villi. However, the variety and number of factors involved (including the large increase in blood supply) are so large that it seems premature to make speculations.…”

Section: Growth Of Mucosa and Serosamentioning

confidence: 99%

Hypertrophy of mucosa and serosa in the obstructed intestine of rats

Bertoni¹,

Gabella²

2001

Journal of Anatomy

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After a surgically induced partial obstruction of the small intestine (ileum) in adult rats there is an accumulation of ingesta and a progressive enlargement of the lumen accompanied by wall thickening : over a period of 2-3 wk the circumference of the hypertrophic intestine increases by a factor of 2n7 and the thickness of the musculature increases more than threefold, while the length of the ileum (measured at the mesenteric attachment) remains unchanged. The villi become markedly larger and more elongated in the circumferential direction, and have a greater separation between one another. The number of villi per unit surface is markedly reduced but the number of villi per unit length of ileum, whilst appearing to show a small increase, was not significantly altered. The component epithelial cells (absorptive cells) appear unchanged in morphology and size (height). The microvilli of the epithelial cells have the same appearance, size (height) and packing density in the control and the hypertrophic ileum. Glands of Lieberku$ hn, Peyer's patches and single lymphatic follicles constituting the Peyer's patches are significantly increased in size in the hypertrophic intestine. The serosal surface of the hypertrophic ileum, in spite of the great expansion, remains regularly covered by mesothelial cells ; these are much larger than in the controls and have an altered distribution of their microvilli.Key words : Intestinal villi ; microvilli ; Peyer's patches ; mesothelium ; hypertrophy ; intestinal obstruction. When the flow of ingesta along the small intestine is impaired, as in the presence of a localised partial obstruction of the lumen, the intestine on the oral side of the obstruction becomes distended and hypertrophic. Enlargement of the lumen and distension of the wall are mechanical effects of the accumulation of ingesta. In contrast, hypertrophy is an active process of growth of the intestinal wall, mainly the musculature, the effect of which is that the wall, in spite of being very distended, is not thinner than in controls but conspicuously thicker. The occurrence of ileal hypertrophy, its relevance to medical conditions (such as obstructions due to pathologic growths or malformations), its scientific significance as a process of growth and adaptation of mature tissues, have been known for a long time. Herczel (1886) was probably the first to describe the structure of hypertrophic intestine, and the process has been analysed in Correspondence to Dr

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Changes in the structure and regeneration mode of the rat small intestinal mucosa following benzalkonium chloride treatment

Cited by 44 publications

References 26 publications

Morphological Alterations in Small Intestine of Rats with Myenteric Plexus Denervation

Morphological Alterations in Small Intestine of Rats with Myenteric Plexus Denervation

The relationship between myenteric neuronal denervation, smooth muscle thickening and epithelial cell proliferation in the rat colon

Hypertrophy of mucosa and serosa in the obstructed intestine of rats

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