Changes in the surface of<i>Dipetalonema viteae</i>(Filarioidea) during its development as shown by comparative peptide mapping

Baschong, Werner

doi:10.1017/s0031182000051040

Cited by 8 publications

(3 citation statements)

References 18 publications

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“…Similar observations have been made with a number of other nematode parasites including Trichinella spiralis (17), Angiostrongytus canlonensis (18), Nemalospiroides dubius (19) and Dipetalonema viteae (20). Furthermore, we have shown, utilising sera from mice infected repeatedly, that many of these compounds are sero-reactive.…”

Section: Discussionsupporting

confidence: 87%

“…We have shown that both the somatic extracts and the ES products of two developmental stages of S. ratfi are highly complex but that both common and stage-specific proteins could be readily demonstrated. Similar observations have been made with a number of other nematode parasites including Trichinella spiralis (17), Angiostrongytus canlonensis (18), Nemalospiroides dubius (19) and Dipetalonema viteae (20). Furthermore, we have shown, utilising sera from mice infected repeatedly, that many of these compounds are sero-reactive.…”

Section: Discussionsupporting

confidence: 87%

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Antigenic analysis of Strongyloides ratti infective larvae and adult worms

Northern

Grove

1987

Immunol Cell Biol

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Summar]'. The protein composition of Strongyloides raiti infective larvae and adult worms extracted sequentially in water, sodium deoxycholate and sodium dodecyl sulphate (SDS) and their excretory/secretory products were analysed by both one-and two-dimensional SDS-polyacrylamide gel electrophoresis. While many bands common to all preparations and both siages of the worm were seen, a number of bands unique to each stage and preparation were identified. Western biol analysis of these larval and adult preparations for reaction with IgG and igM antibodies in hyperimmune mouse sera revealed a large number of antigens. These data provide a framework for analysis of protective and diagnostically useful antigens.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionsupporting

confidence: 87%

Antigenic analysis of Strongyloides ratti infective larvae and adult worms

Northern

Grove

1987

Immunol Cell Biol

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“…Such investigations may be rewarding, since the surface polypeptides of adult L4 and L3 larvae of B. pahangi, that can be labelled with 125 I-iodosulphanilic acid, show a number of stage-specific differences (Marshall & Howells, 1986). In this connection it may also be relevant to note that the surface lipids of microfilarial and adult Litomosoides carinii exhibit variations (Kennedy, Foley, Knox, Harnett, Worms, Kusel, Birmingham & Garland, 1987) and that comparative peptide mapping has shown changes in the surface of Dipetalonema viteae during development and between sexes (Baschong, 1985). Chen & Howells (19816) demonstrated that adult male and female Dirofilaria immitis absorbed a variety of low molecular weight organic nutrients via the transcuticular route.…”

Section: Nbmatodamentioning

confidence: 99%

Ontogenetic changes in helminth membrane function

Arme

1988

Parasitology

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During their life-cycle many parasites experience a wide range of environments including free living and those provided by a variety of intermediate and final hosts. The nutritional requirements of parasites are met by physiological processes adapted to exploit the physicochemical characteristics provided by different hosts. In helminth parasites these adaptations are frequently expressed on the tegumentary surface. As an example of adaptations within the Trematoda, the control of monosaccharide transport in Proterometra sp. is described. Environmental sodium, although not directly involved in the uptake process, nevertheless regulates the expression of transport capabilities. In the Cestoda, the uptake of monosaccharides and amino acids is described for Hymenolepis diminuta. The metacestode of this tapeworm inhabits the blood system of an arthropod, and the adult the gut of a mammal. There are quantitative and qualitative differences in the amino acids and monosaccharides in these two environments and these are reflected in the transport mechanisms exhibited by the two forms of the life-cycle. In Echinococcus granulosus the transfer of amino acids, sugars and macromolecules across the membranes of hydatid cysts and protoscoleces is described. The major difference between these two stages in the life-cycle relates to the ability of hydatid cysts to absorb macromolecules, whereas protoscoleces are impermeable to these compounds. The potential for future work is emphasized.

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