Changes in the timing of reproduction following chronic exposure to ibuprofen in Japanese medaka, Oryzias latipes

Flippin, Jennifer; Huggett, Duane B.; Foran, Christy M.

doi:10.1016/j.aquatox.2006.11.002

Cited by 141 publications

(51 citation statements)

References 30 publications

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“…Female Japanese medaka (the Japanese killifish, Oryzias latipes) exposed to different concentrations of the drug over six weeks, showed a sharp rise in liver weight together with enhanced egg production, yet with a reduction in the number of weekly spawning events [74]. Authors associated these phenomena with changes in the spawning process and vitellogenin production, a glycoprotein precursor in yolk formation.…”

Section: Non-steroidal Anti-inflammatory Drugsmentioning

confidence: 99%

Ecotoxicological aspects related to the presence of pharmaceuticals in the aquatic environment

Santos

Araújo

Fachini

et al. 2010

Journal of Hazardous Materials

1,304

533

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Pharmaceuticals are biologically active and persistent substances which have been recognized as a con-tinuing threat to environmental stability. Chronic ecotoxicity data as well as information on the current distribution levels in different environmental compartments continue to be sparse and are focused on those therapeutic classes that are more frequently prescribed and consumed. Nevertheless, they indicate the negative impact that these chemical contaminants may have on living organisms, ecosystems and ultimately, public health. This article reviews the different contamination sources as well as fate and both acute and chronic effects on nontarget organisms. An extensive review of existing data in the form of tables, encompassing many therapeutic classes is presented.Keywords: Pharmaceuticals, Sources, Environmental fate, Ecotoxicological effects

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Section: Non-steroidal Anti-inflammatory Drugsmentioning

confidence: 99%

Ecotoxicological aspects related to the presence of pharmaceuticals in the aquatic environment

Santos

Araújo

Fachini

et al. 2010

Journal of Hazardous Materials

1,304

533

View full text Add to dashboard Cite

show abstract

“…Investigations into its environmental impacts have found that ibuprofen induced changes on the timing of spawning by medaka (Flippin et al, 2007;Han et al, 2010), growth/ predominance of algae and duckweed (Pomati et al, 2004;Richards et al, 2004), microbial diversity in aquatic mesocosms (Richards et al, 2004), and riverine biofilm communities (Lawrence et al, 2005) at environmentally relevant concentrations.…”

Section: Introductionmentioning

confidence: 99%

Genetic and chemical characterization of ibuprofen degradation by Sphingomonas Ibu-2

Murdoch

2013

Microbiology

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Sphingomonas Ibu-2 has the unusual ability to cleave the acid side chain from the pharmaceutical ibuprofen and related arylacetic acid derivatives to yield corresponding catechols under aerobic conditions via a previously uncharacterized mechanism. Screening a chromosomal library of Ibu-2 DNA in Escherichia coli EPI300 allowed us to identify one fosmid clone (pFOS3G7) that conferred the ability to metabolize ibuprofen to isobutylcatechol. Characterization of pFOS3G7 loss-of-function transposon mutants permitted identification of five ORFs, ipfABDEF, whose predicted amino acid sequences bore similarity to the large and small units of an aromatic dioxygenase (ipfAB), a sterol carrier protein X (SCPx) thiolase (ipfD), a domain of unknown function 35 (DUF35) protein (ipfE) and an aromatic CoA ligase (ipfF). Two additional ORFs, ipfH and ipfI, which encode putative ferredoxin reductase and ferredoxin components of an aromatic dioxygenase system, respectively, were also identified on pFOS3G7. Complementation of a markerless loss-of-function ipfD deletion mutant restored catechol production as did complementation of the ipfF Tn mutant. Expression of subcloned ipfABDEF alone in E. coli did not impart full metabolic activity unless coexpressed with ipfHI. CoA ligation followed by ring oxidation is common to phenylacetic acid pathways. However, the need for a putative SCPx thiolase (IpfD) and DUF35 protein (IpfE) in aerobic arylacetic acid degradation is unprecedented. This work provides preliminary insights into the mechanism behind this novel arylacetic acid-deacylating, catechol-generating activity.

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“…In a similar study of municipal solid waste in Florida, USA, antibiotics as a group was found in the largest quantity, followed by non-steroidal anti-inflammatory drugs [37]. Diclofenac and ibruprofen have been reported in earlier studies to be associated with toxic effects in birds [38], in aquatic life [39] and reduces survival of decomposers [40]. Razor blades were the most common type of sharps waste, as also reported in the study by Cussiol et al (2006) [31].…”

Section: Potential Hazards To Health and Environmentmentioning

confidence: 91%

Making a Case for Diversion of Solid Medical Waste from Households: A Generation Study in Ga South Municipal Assembly, Accra, Ghana

Udofia

Gulis²

2018

JEP

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Background: Solid medical waste (SMW) is generated from the healthcare industry but can also be found in households when activity involving patient care occurs. Its hazardous properties require special treatment to minimize hazards to the environment. To achieve this, SMW must be safely diverted from households using a systemic approach, which should be informed by the quantities generated and factors associated with generation. Objective: To characterize household SMW in terms of quantity and composition and to describe the factors associated with its generation. Methods: Manual sorting of household waste was conducted in 60 households to measure quantities of SMW and its components in Ga South Municipal Assembly, Accra, Ghana. Sample collection took place in the wet season (October, 2014) and dry season (December, 2014/January 2015. Rates of generation and percentage composition computed. Factors influencing generation were evaluated with non-parametric tests and quantile regression analysis. Statistical significance was set at p < 0.05. Results: Per capita generation of SMW was 1.77 × 10 −3 kg/person/day. Pharmaceutical waste and sharps waste comprised 98% and 2% of SMW respectively. Generation rates were significantly higher in the wet season than in the dry season (z = 3.129, p = 0.002). Households where medical complaints were reported generated significantly less SMW at the 5th, 10th, 25th and 50th quantiles (β = −2.711, p = 0.001; β = −2.949; p < 0.001; β = −3.429, p < 0.001; β = −4.600, p < 0.001 respectively). Conclusion: SMW was generated in relatively small quantities in households. However, the large proportion of pharmaceuticals with mostly antibiotics raises concerns about drug resistance among other potential hazards.

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Changes in the timing of reproduction following chronic exposure to ibuprofen in Japanese medaka, Oryzias latipes

Cited by 141 publications

References 30 publications

Ecotoxicological aspects related to the presence of pharmaceuticals in the aquatic environment

Ecotoxicological aspects related to the presence of pharmaceuticals in the aquatic environment

Genetic and chemical characterization of ibuprofen degradation by Sphingomonas Ibu-2

Making a Case for Diversion of Solid Medical Waste from Households: A Generation Study in Ga South Municipal Assembly, Accra, Ghana

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