Changes in the total effective xenoestrogen burden (TEXB) of breast cancer patients during an 18-month post-surgical follow-up

Fernández, Mariana F.; Pumarega, José; Porta, Miquel; Molina-Molina, José-Manuel; Arrebola, Juan Pedro; Olea, Nicolás

doi:10.1016/j.reprotox.2017.03.007

Cited by 5 publications

(2 citation statements)

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“…These results provide support for the role of TR antagonists in the development and/or progression of PTC. Given the promising literature associating bioactivities derived from human tissues or biospecimens with various human health conditions, − using these external noninvasive samplers may present new opportunities to assess potential relationships between contaminant mixtures and human health..…”

Section: Discussionmentioning

confidence: 99%

Thyroid Receptor Antagonism of Chemicals Extracted from Personal Silicone Wristbands within a Papillary Thyroid Cancer Pilot Study

Kassotis

Herkert

Hammel

et al. 2020

Environ. Sci. Technol.

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Research suggests that thyroid cancer incidence rates are increasing, and environmental exposures have been postulated to be playing a role. To explore this possibility, we conducted a pilot study to investigate the thyroid disrupting bioactivity of chemical mixtures isolated from personal silicone wristband samplers within a thyroid cancer cohort. Specifically, we evaluated TRβ antagonism of chemical mixtures extracted from wristbands (n = 72) worn by adults in central North Carolina participating in a case−control study on papillary thyroid cancer. Sections of wristbands were solvent-extracted and analyzed via mass spectrometry to quantify a suite of semivolatile chemicals. A second extract from each wristband was used in a bioassay to quantify TRβ antagonism in human embryonic kidney cells (HEK293/17) at concentrations ranging from 0.1 to 10% of the original extract (by volume). Approximately 70% of the sample extracts tested at a 1% extract concentration exhibited significant TRβ antagonism, with a mean of 30% and a range of 0−100%. Inhibited cell viability was noted in >20% of samples that were tested at 5 and 10% concentrations. Antagonism was positively associated with wristband concentrations of several phthalates, organophosphate esters, and brominated flame retardants. These results suggest that personal passive samplers may be useful in evaluating the bioactivities of mixtures that people contact on a daily basis. We also report tentative associations between thyroid receptor antagonism, chemical concentrations, and papillary thyroid cancer case status. Future research utilizing larger sample sizes, prospective data collection, and measurement of serum thyroid hormone levels (which were not possible in this study) should be utilized to more comprehensively evaluate these associations.

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Section: Discussionmentioning

confidence: 99%

Thyroid Receptor Antagonism of Chemicals Extracted from Personal Silicone Wristbands within a Papillary Thyroid Cancer Pilot Study

Kassotis

Herkert

Hammel

et al. 2020

Environ. Sci. Technol.

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“…A perspective study was conducted by the same research group in order to evaluate the effect of breast cancer treatment (chemotherapy and/or radiotherapy) and the influence of cancer progression on the EDC biomarker (Fernández et al 2017). The authors assessed the estrogenic activity of adipose tissue in breast cancer patients at the diagnosis and during four other consecutive periods (<6, 6-12, 12-18, >18 months) and found that estrogenic activity of both types of extracts (containing xenoestrogens and containing endogenous estrogens -HPLC fractionation technique) increased during the treatment with a maximum peak reached at 6-12 months, suggesting that cancer treatment might influence the levels of the EDC biomarker.…”

Section: Edc Exposure and Adult Adverse Health Effectsmentioning

confidence: 99%

Estrogenic activity of biological samples as a biomarker

Gea¹,

Toso²,

Schilirò³

2020

Science of The Total Environment

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Breast cancer risk and prevention in 2024: An overview from the Breast Cancer UK ‐ Breast Cancer Prevention Conference

Stordal,

Harvie,

Antoniou

et al. 2024

Cancer Medicine

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The Breast Cancer UK—Breast Cancer Prevention Conference addressed risk from environmental pollutants and health behaviour‐related breast‐cancer risk. Epidemiological studies examining individual chemicals and breast cancer risk have produced inconclusive results including endocrine disrupting chemicals (EDCs) Bisphenol A, per‐ and polyfluorinated alkyl substances as well as aluminium. However, laboratory studies have shown that multiple EDCs, can work together to exhibit effects, even when combined at levels that alone are ineffective. The TEXB‐α/β assay measures total estrogenic load, and studies have provided evidence of a link between multiple‐chemical exposures and breast cancer. However, prospective studies using TEXB‐α/β are needed to establish a causative link. There is also a need to assess real‐life exposure to environmental‐chemical mixtures during pregnancy, and their potential involvement in programming adverse foetal health outcomes in later life.Higher rates of breast cancer have occurred alongside increases in potentially‐modifiable risk factors such as obesity. Increasing body‐mass index is associated with increased risk of developing postmenopausal breast cancer, but with decreased risk of premenopausal breast cancer. In contrast, lower rates of breast cancer in Asian compared to Western populations have been linked to soya/isoflavone consumption. Risk is decreased by breastfeeding, which is in addition to the decrease in risk observed for each birth and a young first‐birth. Risk is lower in those with higher levels of self‐reported physical activity. Current evidence suggests breast‐cancer survivors should also avoid weight gain, be physically active, and eat a healthy diet for overall health.A broad scientific perspective on breast cancer risk requires focus on both environmental exposure to chemicals and health behaviour‐related risk. Research into chemical exposure needs to focus on chemical mixtures and prospective epidemiological studies in order to test the effects on breast cancer risk. Behaviour‐related research needs to focus on implementation as well as deeper understanding of the mechanisms of cancer prevention.

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Changes in the total effective xenoestrogen burden (TEXB) of breast cancer patients during an 18-month post-surgical follow-up

Cited by 5 publications

References 50 publications

Thyroid Receptor Antagonism of Chemicals Extracted from Personal Silicone Wristbands within a Papillary Thyroid Cancer Pilot Study

Thyroid Receptor Antagonism of Chemicals Extracted from Personal Silicone Wristbands within a Papillary Thyroid Cancer Pilot Study

Estrogenic activity of biological samples as a biomarker

Breast cancer risk and prevention in 2024: An overview from the Breast Cancer UK ‐ Breast Cancer Prevention Conference

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