Changes in thyroid hormone state in children receiving chemotherapy

Santen, Hanneke M van; Thonissen, N. M.; Kraker, Jan de; Vulsma, Thomas

doi:10.1111/j.1365-2265.2005.02210.x

Cited by 15 publications

(35 citation statements)

References 32 publications

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“…It is known that several drugs influence thyroid function and metabolism 7,26 . This has recently been demonstrated in paediatric cancer patients during chemotherapy 27 . In our study, we were able to show an independent correlation between thyroid abnormalities in patients without irradiation to the head/neck regions and trofosfamide and idarubicin treatment, although there were only a few patients receiving these drugs.…”

Section: Discussionsupporting

confidence: 66%

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Thyroid function in paediatric and young adult patients after sarcoma therapy: a report from the Late Effects Surveillance System

Paulides¹,

Dörr²,

Stöhr³

et al. 2007

Clinical Endocrinology

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Section: Discussionsupporting

confidence: 66%

“…The criteria employed for l ‐thyroxine (T4) supplementation treatment were unclear in our cohort. Only 53% (19/36) of patients with overt and subclinical hypothyroidism received l ‐T4 supplementation, even though it is recommended in affected children 17,27,31 . Data on thyroid cancer as a second malignancy were not available.…”

Section: Discussionmentioning

confidence: 99%

Thyroid function in paediatric and young adult patients after sarcoma therapy: a report from the Late Effects Surveillance System

Paulides¹,

Dörr²,

Stöhr³

et al. 2007

Clinical Endocrinology

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“…We include this description of these subjects to avoid the lost to follow-up because of sudden death [22] and the diagnostic bias due to other exposure status. Specifically, patients with known autoimmune diseases [23] or using drugs that may interfere with thyroid function [24,25] are prone to develop autoimmune thyroiditis or subclinical hypothyroidism. Furthermore, 2 subjects refused to continue the study and 3 were lost to follow-up.…”

Section: Methodsmentioning

confidence: 99%

Ten-Year Longitudinal Study of Thyroid Function in Children with Down's Syndrome

et al. 2014

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Background/Aims: The natural history of thyroid function in children with Down's syndrome is relatively unknown. We hypothesized that in these patients the occurrence of thyroid dysfunction rises during development. Methods: Thyroid function was assessed yearly in 145 children with Down's syndrome, all followed from birth up to 10 years of age. Heteroskedastic binary and ordinary logistic regression for repeated measures was used to evaluate the relationship of thyroid function with continuous time. Results: Congenital hypothyroidism was detected in 7% of cases. The probability of acquired thyroid dysfunction increased from 30% at birth to 49% at 10 years (p < 0.001). The subclinical hypothyroidism was nearly stable during the follow-up. The probability of hypothyroidism increased from 7 to 24% at 10 years (p < 0.001). Positive anti-thyroglobulin antibodies were associated with higher odds of more severe hypothyroidism (odds ratio 3.6). Positive anti-thyroid peroxidase antibodies were a better predictor of more severe hypothyroidism (odds ratio 6.1). Diffuse hypoechogenicity on thyroid ultrasound was found in 34 out of 145 children. Conclusion: The probability of thyroid dysfunction increasing during development is higher than previously reported. Such children should be carefully monitored annually to early identify thyroid dysfunction.

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“…Although it is well known that radiation exposure of the thyroid gland can induce hypothyroidism, its potential influence can be ignored in this study because radiation-induced hypothyroidism would be detected several years after completion of irradiation 48. Furthermore, possible influence of CDDP-based chemotherapy on thyroid function has been reported in children 49.…”

Section: Discussionmentioning

confidence: 97%

THRB Genetic Polymorphisms Can Predict Severe Myelotoxicity after Definitive Chemoradiotherapy in Patients with Esophageal Squamous Cell Carcinoma

Miki¹,

Nakamura²,

Kuwahara³

et al. 2012

Int. J. Med. Sci.

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Objective: Chemotherapy-related toxicities are difficult to predict before treatment. In this study, we investigated whether thyroid hormone receptor beta (THRB) genetic polymorphisms can serve as a potential biomarker in patients with esophageal squamous cell carcinoma (ESCC).Methods: Forty-nine Japanese patients with ESCC who received a definitive chemoradiotherapy (CRT) with 5-fluorouracil and cisplatin in conjunction with concurrent irradiation were retrospectively analyzed. Severe acute toxicities, including leukopenia, stomatitis, and cheilitis, were evaluated according to 6 single nucleotide polymorphisms (SNPs) in the gene; the intronic SNPs of rs7635707 G/T, rs6787255 A/C, rs9812034 G/T, and rs9310738 C/T and the SNPs in the 3′-untranslated region (3′-UTR) of rs844107 C/T and rs1349265 G/A.Results: Distribution of the 4 intronic SNPs, but not the 2 SNPs in the 3′-UTR, showed a significant difference between patients with and without severe acute leukopenia. Stomatitis and cheilitis were not associated with any of the 6 analyzed SNPs. Frequency of haplotype of the 4 intronic SNPs reached approximately 97% with the 2 major haplotypes G-A-G-C (73.4%) and T-C-T-T (23.5%).Conclusions: THRB intronic SNPs can provide useful information on CRT-related severe myelotoxicity in patients with ESCC. Future studies will be needed to confirm these findings.

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Changes in thyroid hormone state in children receiving chemotherapy

Cited by 15 publications

References 32 publications

Thyroid function in paediatric and young adult patients after sarcoma therapy: a report from the Late Effects Surveillance System

Thyroid function in paediatric and young adult patients after sarcoma therapy: a report from the Late Effects Surveillance System

Ten-Year Longitudinal Study of Thyroid Function in Children with Down's Syndrome

THRB Genetic Polymorphisms Can Predict Severe Myelotoxicity after Definitive Chemoradiotherapy in Patients with Esophageal Squamous Cell Carcinoma

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