Changes in Thyroid Hormones Levels and Metabolism in Dairy Cows around Calving

Fiore, Enrico; Giambelluca, Sonia; Morgante, Massimo; Piccione, Giuseppe; Vazzana, Irene; Contiero, Barbara; Orefice, Tiziana; Arfuso, Francesca; Gianesella, Matteo

doi:10.1515/acve-2017-0026

Cited by 9 publications

(4 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…MSTN has critical roles in many aspects of metabolism such as glucose and lipid metabolism [ 8 , 9 ]. Hormone levels in vivo are key to glucose metabolism, such as insulin and thyroid hormones [ 10 , 11 , 12 ]. MSTN inactivation attenuates skeletal muscle insulin resistance and regulates glucose metabolism [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Myostatin Knockout Regulates Bile Acid Metabolism by Promoting Bile Acid Synthesis in Cattle

Wei

et al. 2022

Animals

View full text Add to dashboard Cite

Myostatin (MSTN) is a major negative regulator of skeletal muscle mass and causes a variety of metabolic changes. However, the effect of MSTN knockout on bile acid metabolism has rarely been reported. In this study, the physiological and biochemical alterations of serum in MSTN+/− and wild type (WT) cattle were investigated. There were no significant changes in liver and kidney biochemical indexes. However, compared with the WT cattle, lactate dehydrogenase, total bile acid (TBA), cholesterol, and high-density lipoprotein (HDL) in the MSTN+/− cattle were significantly increased, and glucose, low-density lipoprotein (LDL), and triglycerides (TG) were significantly decreased, indicating that MSTN knockout affected glucose and lipid metabolism and total bile acids content. Targeted metabolomic analysis of the bile acids and their derivatives was performed on serum samples and found that bile acids were significantly increased in the MSTN+/− cattle compared with the WT cattle. As the only bile acid synthesis organ in the body, we performed metabolomic analysis on the liver to study the effect of MSTN knockout on hepatic metabolism. Metabolic pathway enrichment analysis of differential metabolites showed significant enrichment of the primary bile acid biosynthesis and bile secretion pathway in the MSTN+/− cattle. Targeted metabolomics data further showed that MSTN knockout significantly increased bile acid content in the liver, which may have resulted from enhanced bile acid synthesis due to the expression of bile acid synthesis genes, cholesterol 7 alpha-hydroxylase (CYP7A1) and sterol 27-hydroxylase (CYP27A1), and upregulation in the liver of the MSTN+/− cattle. These results indicate that MSTN knockout does not adversely affect bovine fitness but regulates bile acid metabolism via enhanced bile acid synthesis. This further suggests a role of MSTN in regulating metabolism.

show abstract

Section: Introductionmentioning

confidence: 99%

Myostatin Knockout Regulates Bile Acid Metabolism by Promoting Bile Acid Synthesis in Cattle

Wei

et al. 2022

Animals

View full text Add to dashboard Cite

show abstract

“…In ruminants, Fiore et al (2017) reported that thyroid hormones (T3 and T4) contributed in growth metabolism, heart contraction, cholesterol and protein synthesis, nutrients metabolism, an increased basal metabolic rate and the availability of glucose. Partial replacement of SM in the present study leads to increased thyroid hormones compared to the control group, which may be responsible for higher body weight gain through increasing basal metabolic rate.…”

Section: Discussionmentioning

confidence: 99%

Growth performance, nutrient digestion, rumen fermentation and blood biochemistry in response to partially replacing cottonseed cake with sesame meal in a lamb feedlot diet

Abdullah,

Gomaa,

Hassan

et al. 2023

Animal Physiology Nutrition

View full text Add to dashboard Cite

Recently, it is necessary to formulate high‐quality, balanced and low‐cost rations for ruminants from nontraditional sources. The present study conducted to investigate the impact of partially replacing corticated cottonseed (CS) cake with sesame meal (SM) in a lamb feedlot diet on growth performance, nutrient digestion, rumen fermentation and blood biochemistry. Fifteen growing lambs with an initial body weight of 27.4 ± 1.2 kg (6–7 months old) were randomly assigned into three equal groups (n = 5). Lambs in control group (CS) fed a basal diet, while 8% and 16% SM were used to replace an equal portion of corticated CS cake in the second (8SM) and third (16SM) groups respectively. Results showed that most parameters of growth performance and nutrient digestibility were significantly improved (p < 0.05) with the partial replacement of SM (8SM and/or 16SM). Regarding ruminal parameters, ruminal pH and total volatile fatty acids concentration increased (p < 0.05), while ammonia level and total protozoa count decreased with the partial replacement of SM. Moreover, blood parameters showed variant responses to SM partial replacement. Total protein increased, and glucose decreased significantly with 16SM, while cholesterol showed a significant decreasing with both SM replacement levels. SM may substitute CS cake in lamb diet without detrimental effects on performance, digestibility and ruminal fermentation.

show abstract

“…The estimation of various hematobiochemical parameters assists in comprehending the association of blood characteristics to the habitation and adaptability of animals to the environment. Variations in blood parameters depends on the species, sex, age and nutritional and physical condition of animals (Arfuso et al, 2016;Fiore et al, 2017;Fiore et al, 2018). The investigation of blood parameters in animals represents a crucial tool in the advancement of management conditions, especially concerning the detection of healthy versus infected or stressed animals (Carcangiu et al, 2018;Arfuso et al, 2023;Perillo et al, 2021;Arfuso et al, 2022).…”

Section: Effect Of Cold Stress On Health Statusmentioning

confidence: 99%

Mitigating Cold Stress in Livestock by Nutritional Interventions: A Comprehensive Review

Sahib,

Aafaq,

Ahmed

et al. 2024

IJAR

View full text Add to dashboard Cite

Climate change has been the major threat to livestock systems sustainability globally. This climate change has provoked many stressors, for instance, cold, heat, humidity, rain, ice and wind, that can directly or indirectly exert influence on the endocrine system and impact the performance of an animal including their production potential, reproductive system and regular estrous cycle. Also, the environmental stressors can contribute to the amenability of animals to infections; it is therefore, vital to understand how stressors alter the animal’s adaptive capacity and efficient methods in coping stress. This review aims at the scientific evidences regarding challenges due to cold stress and its potential mitigation by nutritional interventions. The cold is amongst the most potential environmental stressors which can adversely affect production potential as well as the growth of animals. Under cold stress the animals’ dietary intake increases, but the production capacity declines, furthermore, it can also culminate in physiological fluctuations, behavioral shift, tissue and intestinal impairment and soaring death rate. Maintenance of animal in its thermoneutral zone is important, otherwise any deviation from it proves life threatening. So, to cut back on the economic losses timely course of action must be taken to prevent the damages ascribed to the stressor. To maintain the production performance along with profitability, it is thus recommended to adapt scientific feeding regimens and also incorporate feed supplements (especially vitamins and minerals) to combat the devastating effects of cold stress.

show abstract

Changes in Thyroid Hormones Levels and Metabolism in Dairy Cows around Calving

Cited by 9 publications

References 31 publications

Myostatin Knockout Regulates Bile Acid Metabolism by Promoting Bile Acid Synthesis in Cattle

Myostatin Knockout Regulates Bile Acid Metabolism by Promoting Bile Acid Synthesis in Cattle

Growth performance, nutrient digestion, rumen fermentation and blood biochemistry in response to partially replacing cottonseed cake with sesame meal in a lamb feedlot diet

Mitigating Cold Stress in Livestock by Nutritional Interventions: A Comprehensive Review

Contact Info

Product

Resources

About