Changes in Tumor Necrosis Factor-α, Heat Shock Protein 70, Malondialdehyde, and Superoxide Dismutase in Patients With Different Severities of Alcoholic Fatty Liver Disease

Qu, Baoge; Wang, Hui; Jia, Yuhua; Su, Ji-Liang; Wang, Zhongdong; Wang, Yafei; Han, Xiaohua; Liu, Yuan-Xun; Pan, Jiang; Ren, Guangying

doi:10.1097/md.0000000000000643

Cited by 14 publications

(8 citation statements)

References 35 publications

(40 reference statements)

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“…OS and inflammation have been confirmed in patients with ALD, in several studies. Qu et al [ 134 ], observed that heat shock protein 70 (HSP70), an intracellular polypeptide involved in immune responses, contributing to vascular damage and TNF-α release, was increased in alcoholic fatty liver disease. Grasselli et al (2014) [ 135 ] also identified a redox imbalance in ALD subjects: increase of lipid peroxidation and stimulation of the activities of the antioxidant enzymes CAT and SOD [ 135 ].…”

Section: Discussionmentioning

confidence: 99%

Oxidative Stress and Inflammation in Hepatic Diseases: Therapeutic Possibilities of N-Acetylcysteine

Andrade

Moura

Santos

et al. 2015

IJMS

198

140

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Liver disease is highly prevalent in the world. Oxidative stress (OS) and inflammation are the most important pathogenetic events in liver diseases, regardless the different etiology and natural course. N-acetyl-l-cysteine (the active form) (NAC) is being studied in diseases characterized by increased OS or decreased glutathione (GSH) level. NAC acts mainly on the supply of cysteine for GSH synthesis. The objective of this review is to examine experimental and clinical studies that evaluate the antioxidant and anti-inflammatory roles of NAC in attenuating markers of inflammation and OS in hepatic damage. The results related to the supplementation of NAC in any form of administration and type of study are satisfactory in 85.5% (n = 59) of the cases evaluated (n = 69, 100%). Within this percentage, the dosage of NAC utilized in studies in vivo varied from 0.204 up to 2 g/kg/day. A standard experimental design of protection and treatment as well as the choice of the route of administration, with a broader evaluation of OS and inflammation markers in the serum or other biological matrixes, in animal models, are necessary. Clinical studies are urgently required, to have a clear view, so that, the professionals can be sure about the effectiveness and safety of NAC prescription.

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Section: Discussionmentioning

confidence: 99%

Oxidative Stress and Inflammation in Hepatic Diseases: Therapeutic Possibilities of N-Acetylcysteine

Andrade

Moura

Santos

et al. 2015

IJMS

198

140

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“…The protocol was approved by the clinical research ethics committee of Taishan Hospital in Shandong Province. The exclusion criteria for the subjects have been described in a previous publication 14 .…”

Section: Methodsmentioning

confidence: 99%

The Correlation and Risk Factors between Carotid Intima-Media Thickening and Alcoholic Liver Disease Coupled with Helicobacter pylori Infection

Wang

Jia

et al. 2017

Sci Rep

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The aim of this study was to explore the associations and differences in influencing factors between alcoholic liver disease (ALD) coupled with Helicobacter pylori infection and atherosclerosis and to determine whether there is a “double hit phenomenon” in atherosclerosis patients with ALD and H. pylori infections. Included cases (n = 160) were categorized into 4 groups: 41 cases of ALD coupled with H. pylori infections (group A), 35 cases of H. pylori infections without ALD (group B), 37 cases of ALD without H. pylori infections (group C), and 47 normal control cases (group D). CIMT was significantly greater in group A than in groups B and D (P = 0.005 and P = 0.001, respectively). The GLM univariate analysis found that CIMT was significantly greater in group A than in groups B, C and D (P = 0.018, P = 0.001 and P = 0.009, respectively). We found that BMI and ALT, AST and ApoB levels were independent predictors of CIMT (P = 0.000, P = 0.000, P = 0.012 and P = 0.014, respectively). ALD coupled with H. pylori infection may result in significant CIMT thickening, but H. pylori infection without ALD and ALD without H. pylori infection does not, suggesting that a “double hit phenomenon” occurs. Additionally, BMI, and ALT, AST and ApoB levels were independent risk factors for increased CIMT.

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“… 11 Our previous study showed that CIMT correlated with age and metabolic factors in subjects with alcoholic fatty liver disease. 12 Additionally, previous studies have shown that the CIMT quartile is significantly higher in subjects with a higher BMI. 13 , 14 The present study found that among patients who ingested alcohol, those with increased CIMT were older than were those with a normal CIMT.…”

Section: Discussionmentioning

confidence: 96%

Risk Factors Associated With Increased Carotid Intima-Media Thickness in a Male Population With Chronic Alcohol Consumption

Liu

et al. 2016

Medicine

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Previous studies have reported a relationship between alcohol consumption and carotid intima-media thickness (CIMT). However, the exact associations between different severities of CIMT and dyslipidemia, dyslipoproteinemia, inflammatory immune markers, and oxidative markers associated with chronic alcohol consumption remain unknown.The aim of this study was to explore whether there are associations between different severities of CIMT and dyslipidemia, dyslipoproteinemia, inflammatory immune markers, and oxidative markers associated with chronic alcohol consumption.We enrolled 173 males with chronic alcohol consumption and categorized them into 2 groups: 104 chronic alcohol consumers with normal CIMT (group A) and 69 chronic alcohol consumers with increased CIMT (group B).Nonparametric statistics showed that age, body mass index (BMI), and serum TC, TG, Apo A1, and ApoB levels were significantly higher in group B than in group A (P = 0.002, 0.019, 0.021, 0.023, 0.001, and 0.001, respectively). Additionally, tumor necrosis factor alpha (TNFα) and HSP70 serum levels were significantly lower in group B than in group A (P = 0.023 and 0.017, respectively). A binary logistic regression analysis showed that age (OR: 1.077, 95% CI: 1.024–1.13, P = 0.004), ApoB (OR: 6.828, 95% CI: 1.506–30.956, P = 0.013), and TNF-α (OR: 0.999, 95% CI: 0.998–1.00) were independent risk factors associated with CIMT.The present study demonstrated that age, ApoB, and TNFα are independent risk factors associated with CIMT. Thus, older subjects with increased serum ApoB levels are more likely to present with increased CIMT, suggesting that age and ApoB promote such thickening and that TNFα downregulation might play a protective role against the progression of subclinical atherosclerosis in subjects with chronic alcohol consumption.

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Changes in Tumor Necrosis Factor-α, Heat Shock Protein 70, Malondialdehyde, and Superoxide Dismutase in Patients With Different Severities of Alcoholic Fatty Liver Disease

Cited by 14 publications

References 35 publications

Oxidative Stress and Inflammation in Hepatic Diseases: Therapeutic Possibilities of N-Acetylcysteine

Oxidative Stress and Inflammation in Hepatic Diseases: Therapeutic Possibilities of N-Acetylcysteine

The Correlation and Risk Factors between Carotid Intima-Media Thickening and Alcoholic Liver Disease Coupled with Helicobacter pylori Infection

Risk Factors Associated With Increased Carotid Intima-Media Thickness in a Male Population With Chronic Alcohol Consumption

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