Changes in type of hemoglobin during experimental hemorrhagic anemias in sheep

Mh, Blunt

doi:10.1152/ajplegacy.1965.209.5.986

Cited by 12 publications

(4 citation statements)

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“…The relationship between anaemia and the occurrence of haemoglobin C in animals of haemoglobin type A and AB was confirmed by partial exsanguination experiments, performed in a similar way to those described by van Vliet and Huisman (1964), Blunt (1965) and Kitchen et al (1968). In six sheep with haemoglobin type AB and in one animal with type A the abnormal haemoglobin was produced after about three weeks, while 16 animals of haemoglobin type B never developed the C band of haemoglobin.…”

Section: Blood Grps Biochem Genet 2 (1971)supporting

confidence: 59%

Haemoglobin types and the geeldikkop‐enzootic icterus disease complex in sheep

Osterhoff

1971

Animal Blood Groups and Biochemical Genetics

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Section: Blood Grps Biochem Genet 2 (1971)supporting

confidence: 59%

Haemoglobin types and the geeldikkop‐enzootic icterus disease complex in sheep

Osterhoff

1971

Animal Blood Groups and Biochemical Genetics

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“…Striking increases of Hb F have been seen in patients with juvenile chronic granulocytic leukaeinia (Maurer et al, 1972). In some animals, anaemia and hypoxia lead to switching of adult haemoglobin types (Blunt, 1965), and recent evidence indicates that this change is mediated by erythropoietin (Adamson & Stamatoyannopoulos, 1973).…”

Section: Discussionmentioning

confidence: 99%

Haemoglobin C/α Thalassaemia: Haematological and Biosynthetic Studies

Steinberg

1975

Br J Haematol

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A family with genes for haemoglobin C (Hb C) and alpha thalassaemia was studied. The mother had Hb-C trait. The father also had Hb-C trait but in addition displayed microcytosis, elevated Hb-F levels and a concentration of Hb-C less than usual for heterozygotes. The proband was homozygous for Hb-C but had Hb-F levels far exceeding those present in Hb-C disease. Biosynthetic studies of globin synthesis in both father and daughter showed a deficit of alpha chains relative to non-alpha chains, confirming the presence of alpha thalassaemia. The coexistence of alpha thalassaemia influences the level of mutant haemoglobin in haemoglobinopathies in which Hb C is present, in a fashion similar to that observed in sickle-cell trait.

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“…(c) Haemoglobin C. Huisman, van der Helm, Visser & van Vliet (1959) noticed that the relative proportions of HbA and HbB in the blood of HbAB-type sheep changed when they were severely anaemic as a result of infestation with Strongylus. Later it was observed that when sheep of Hb type A or AB are severely anaemic as a result of haemorrhage or worm infestation, the production of HbA ceases and another haemoglobin is produced Braend, Efremov & Helle, 1964;van Vliet & Huisman, 1964;Blunt, 1965). This was named 'C' by van Vliet & Huisman and 'N' by Braend et al, it only occurs in sheep which carry the gene for A haemoglobin.…”

Section: (6) Frequencies In Diyerent Breedsmentioning

confidence: 99%

Genetic Variation in the Sheep Red Blood Cell

Tucker¹

1971

Biological Reviews

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Summary 1. There are 7 well‐established red‐cell antigen (blood group) loci. The R‐O system has 3 phenotypes, R, O and i, identified by the ‘naturally occurring’ antibodies, anti‐R and anti‐O. The R and O substances are also present in soluble form in some body secretions. The expression of R and O is controlled by a dominant gene I, epistatic in effect, at an independent locus from that of R. The systems, A, C, M‐L, B, D and X‐2 are identified by means of ‘immune‐type’ antibodies, and several of the loci have multiple alleles. An isoenzymic form of serum alkaline phosphatase is associated with the R‐O system. The frequency for the genes at the various loci has been determined in a limited number of breeds. 2. Some sheep red cells have high K+ and low Na+ concentrations (HK type, or Key), others have low K+ and high Na+ concentrations (LK type or Kea). Two other rare forms exist; Key type which is HK but with lower than normal K+ values, and Kep type which has approximately equal Na+ and K+ concentrations. The red cells of foetuses and newborn lambs have high K+ levels irrespective of their potassium genotype. HK cells have 3–4 times greater (Na+‐K+)‐activated ATPase activity, a 3–4 times increased rate of active K+ transport and a larger number of ouabain‐binding sites than LK cells. Antigen M is present on homozygous HK and heterozygous LK red cells, and antigen L is present on homozygous and heterozygous LK red cells. Sensitization of LK cells with anti‐L stimulates active K+ transport and ATPase activity and exposes a larger number of ouabain‐binding sites in these cells. Anti‐M has no effect. The red cells of newborn lambs only show weak L and M antigen activity. It is postulated that L antigen inhibits cation transport in LK cells by masking the pump sites on the membrane. Immature red cells in LK‐type sheep have a high rate of active K+ transport and yet have L antigen present. No satisfactory explanation for this has yet been advanced. There is no conclusive evidence that the potassium types have any significance from the point of view of adaptation or sheep breeding. The potassium‐gene frequencies are known for a large number of breeds. 3. Two allelic genes, Hb4 and HbB control 3 haemoglobin phenotypes, A, AB, and B. Foetal haemoglobin (HbF) is present in foetuses and newborn lambs. Sheep with HbA also synthesize small amounts of another haemoglobin (HbC) and under conditions of severe anaemia, synthesis of HbC takes over from that of HbA. No change in HbB is observed in anaemia. A rare haemoglobin (HbD) has been found in 3 Yugoslavian sheep. Hbs A, B, C and F differ in their physicochemical properties; they share the same alpha chains but their non‐alpha chains differ in a number of amino acids. HbD differs from HbA in one amino acid in the alpha chain. Certain genetic aspects are discussed. There is some evidence that sheep with HbA are less fertile than those with HbB. The gene frequencies for Hb are known for a large number of breeds. 4. Two isoenzymic forms of carbonic anhydrase are found in red‐cel...

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Changes in type of hemoglobin during experimental hemorrhagic anemias in sheep

Cited by 12 publications

References 0 publications

Haemoglobin types and the geeldikkop‐enzootic icterus disease complex in sheep

Haemoglobin types and the geeldikkop‐enzootic icterus disease complex in sheep

Haemoglobin C/α Thalassaemia: Haematological and Biosynthetic Studies

Genetic Variation in the Sheep Red Blood Cell

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