Changes in vagal reactivity to the sympathicotonia during the progression of heart failure: From self-suppression to counteraction

Miličević, Goran; Udiljak, Nikola; Milicevic, Tena

doi:10.1016/j.mehy.2013.04.033

Cited by 3 publications

(2 citation statements)

References 16 publications

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“…The autonomic nervous system has been shown to have a powerful influence on the QT interval 31 . HF is characterized by profound changes in autonomic function, with a markedly reduced vagal tone in favour of sympathetic overdrive 32 , that in turn can prolong the QT interval. Our results showed that QTc average duration was significantly longer in patients with "bad" PROs compared to patients with "good" PROs.…”

Section: Discussionmentioning

confidence: 99%

Association of patient-reported outcomes and heart rate trends in heart failure: a report from the Chiron project

Monzo

Schiariti

Calvisi

et al. 2020

Sci Rep

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patient-reported outcomes (pRos) have been previously considered "soft" end-points because of the lack of association of the reported outcome to measurable biological parameters. the present study aimed to assess whether electrocardiographic measures are associated to pRos changes. We evaluated the association between heart rate (HR), QRS and QT/QTc durations and PROs, classified as "good" or "bad" according to the patients' overall feeling of health, in patients from the chiron project. twentyfour chronic heart failure (HF) patients were enrolled in the study (71% male, mean age 62.9 ± 9.4 years, 42% ischemic etiology, 15 NYHA class II and 9 class III) providing 1086 days of usable physiological recordings (4 hours/day). The mean HR was significantly higher in the "bad" than in the "good" PROs class (74.0 ± 6.4 bpm vs 68.0 ± 7.2 bpm; p < 0.001). Conversely, the ratio between movement and rest activities showed significantly higher values in "good" compared to "bad" PROs. We also found significantly longer QTc and QRS durations in patients with "bad" PROs compared to patients with "good" pRos. that in patients with mild to moderate Hf, higher HR, wider QRS and longer Qtc, as well as a reduced HR ratio between movement and rest, were associated with "bad" pRos is clinically noteworthy because the association of worse pRos with measurable variations of biological parameters may help physicians in evaluating pRos reliability itself and in their clinical decisions. Whether a timely intervention on these biological parameters may prevent adverse outcomes is important and deserves to be investigated in further studies.

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Section: Discussionmentioning

confidence: 99%

Association of patient-reported outcomes and heart rate trends in heart failure: a report from the Chiron project

Monzo

Schiariti

Calvisi

et al. 2020

Sci Rep

View full text Add to dashboard Cite

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“…Известно, что при вибрации происходит нарушение вегетативной регуляции на разных уровнях (в ретикулярной формации головного мозга, в спинном мозге и в надсегментарных вегетативных структурах), что приводит к развитию симпатикотонии [18]. В свою очередь, согласно данным экспериментальных исследований, длительная симпатикотония способствует уменьшению количества β1-АР [22], а также изменению их структуры и приобретению ими антигенных свойств. В свою очередь, ауто-АТ к измененным β1-АР обладают катехоламиноподобными эффектами и способны оказывать на них стимулирующее действие [20], вызывая повышение частоты сокращения кардиомиоцитов in vitro без развития десенситизации.…”

Section: Discussionunclassified

Autoantibody as markers of the heart state in patients with vibration disease burdened diabetes mellitus

Masnavieva¹,

Kudaeva²,

Кузнецова³

2020

Med. immunol.

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Physical and chemical factors, obesity, lipid metabolism disorder, diabetes affect the state of the vascular endothelium, the processes of thrombus formation, fibrinolysis and increase the risk of developing cardiovascular diseases. It can be assumed that the development and course of pathological processes in the cardiovascular system, caused by vibration disease with the onset of diabetes, will undergo changes. The purpose of the study was to assess the state of heart condition according to the level of specific autoantibodies with the combined effect of vibration disease and type 2 diabetes mellitus. Patients with vibration disease (group I), patients with type 2 diabetes (group II) and persons with vibration disease in combination with type 2 diabetes (group III) were examined. Individuals do not have a history of coronary heart disease, stroke, and myocardial infarction have been included in obsledrovanie. Serum levels of specific autoantibodies characterizing the state of the heart have been studied. It was revealed that the content of autoantibodies to 1-adrenoreceptors in patients of group I was higher than in individuals of group II. The relative content of autoantibodies to the components of the membrane and cytoplasm of myocardial cells in patients of groups I-III did not differ. It was found that elevated levels of autoantibodies to components of the membrane and cytoplasm of myocardial cells, cardiomyosin, 1-adrenoreceptors were observed more often in patients with vibration disease combined with diabetes and in persons with vibration disease than in people with diabetes. Persons with a reduced content of autoantibodies to 1-adrenergic receptors were not detected among patients of groups I and III. Changes in the levels of specific autoantibodies in persons with vibration disease may indicate the development of functional metabolic and structural changes in the heart, disorders of its electrical activity that have not yet been manifested in the form of a pathological process. Lower levels of 1-adrenoceptor autoantibodies in patients with type 2 diabetes without vibration disease can be caused by increased levels of catecholamines, which is characteristic of diabetics. Further research, including clinical data and indicators of functional diagnostics is necessary to confirm our assumptions.

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Effect of short-term exposure to particulate air pollution on heart rate variability in normal-weight and obese adults

Zhang

et al. 2021

Environ Health

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Background The adverse effects of particulate air pollution on heart rate variability (HRV) have been reported. However, it remains unclear whether they differ by the weight status as well as between wake and sleep. Methods A repeated-measure study was conducted in 97 young adults in Beijing, China, and they were classified by body mass index (BMI) as normal-weight (BMI, 18.5–24.0 kg/m2) and obese (BMI ≥ 28.0 kg/m2) groups. Personal exposures to fine particulate matter (PM2.5) and black carbon (BC) were measured with portable exposure monitors, and the ambient PM2.5/BC concentrations were obtained from the fixed monitoring sites near the subjects’ residences. HRV and heart rate (HR) were monitored by 24-h Holter electrocardiography. The study period was divided into waking and sleeping hours according to time-activity diaries. Linear mixed-effects models were used to investigate the effects of PM2.5/BC on HRV and HR in both groups during wake and sleep. Results The effects of short-term exposure to PM2.5/BC on HRV were more pronounced among obese participants. In the normal-weight group, the positive association between personal PM2.5/BC exposure and high-frequency power (HF) as well as the ratio of low-frequency power to high-frequency power (LF/HF) was observed during wakefulness. In the obese group, personal PM2.5/BC exposure was negatively associated with HF but positively associated with LF/HF during wakefulness, whereas it was negatively correlated to total power and standard deviation of all NN intervals (SDNN) during sleep. An interquartile range (IQR) increase in BC at 2-h moving average was associated with 37.64% (95% confidence interval [CI]: 25.03, 51.51%) increases in LF/HF during wakefulness and associated with 6.28% (95% CI: − 17.26, 6.15%) decreases in SDNN during sleep in obese individuals, and the interaction terms between BC and obesity in LF/HF and SDNN were both statistically significant (p < 0.05). The results also suggested that the effects of PM2.5/BC exposure on several HRV indices and HR differed in magnitude or direction between wake and sleep. Conclusions Short-term exposure to PM2.5/BC is associated with HRV and HR, especially in obese individuals. The circadian rhythm of HRV should be considered in future studies when HRV is applied. Graphical abstract

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Changes in vagal reactivity to the sympathicotonia during the progression of heart failure: From self-suppression to counteraction

Cited by 3 publications

References 16 publications

Association of patient-reported outcomes and heart rate trends in heart failure: a report from the Chiron project

Association of patient-reported outcomes and heart rate trends in heart failure: a report from the Chiron project

Autoantibody as markers of the heart state in patients with vibration disease burdened diabetes mellitus

Effect of short-term exposure to particulate air pollution on heart rate variability in normal-weight and obese adults

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