Changes in VEGF and nitric oxide after deep dermal injury in the female, red Duroc pig—further similarities between female, Duroc scar and human hypertrophic scar

A biochemical comparison of the in vivo effects of Bulbine frutescens and Bulbine natalensis on cutaneous wound healing

“…It is possible that increasing the experimental time even further may demonstrate collagen remodelling more clearly. In wound experiments on the red Duroc pig, Zhu et al (2005) demonstrated that skin is restored to its normal structure in 6-8 weeks. New collagen formation continues for up to 6 weeks post-wounding.…”

Vascular Endothelial Growth Factor and Angiogenesis in the Regulation of Cutaneous Wound Repair

“…[73][74][75][76][77][78][79][80] This suggests that inhibiting VEGF might be useful for reducing scar formation. Reducing VEGF and the overall number of blood vessels in a healing wound might seem risky; however, a significant proportion of new blood vessels in a wound are immature and not perfused.…”

“…73 In addition, injection of recombinant VEGF resulted in the formation of large scars in embryonic day 15 fetal wounds, which normally heal without scars. 73 Abnormal scars, such as hypertrophic scars 74,75 and keloids, 76,77 have been shown to express high levels of VEGF. Treatment of hypertrophic scar patients with interferon a 2b has been linked to a reduction in angiogenesis and VEGF, 78 suggesting that reducing VEGF may improve scars.…”

Air plasma-generated nitric oxide in treatment of skin scars and articular musculoskeletal disorders: Preliminary review of observations

“…However, the data on its use obtained so far are controversial. On the one hand, it was recognized that the levels of nitric oxide in deep wounds and scars are reduced in comparison to its amount in healthy tissue [35][36]. In our previous investigations the high efficacy of plasma gNO therapy was observed in the treatment of radiation-induced skin fibrosis in cancer patients [6,37].…”