Changes in Vessel Density of the Patients with Narrow Antenior Chamber after an Acute Intraocular Pressure Elevation Observed by OCT Angiography

Ma, Ziwei; Qiu, Wen-han; Zhou, Dan-ni; YANG, WEIHUA; Pan, Xue-feng; CHEN, HONG

doi:10.21203/rs.2.368/v3

Cited by 7 publications

(7 citation statements)

References 25 publications

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“…Some investigations have indicated that anterior segment ischaemia caused APAC and that retinal ischaemia may be present after an APAC episode 29 . In addition, Ma et al found that macular and papillary VD decreased significantly in eyes with narrow anterior chambers after an acute IOP elevation recently 30 . Therefore, the dropout of macular VD in APAC eyes may be due to the elevated IOP.…”

Section: Discussionmentioning

confidence: 99%

Macular vessel density and foveal avascular zone parameters in patients after acute primary angle closure determined by OCT angiography

Liu

Jiang

et al. 2020

Sci Rep

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This study analyzed the optical coherence tomography angiography (OCTA) macular parameters in primary angle-closure glaucoma (PACG) patients after acute primary angle closure (APAC) episodes. Thirty-three patients with 33 APAC eyes and 33 primary angle closure suspect (PACS) eyes and 33 age-matched normal subjects (controls) were enrolled. Macular vessel density (VD) in central, inner, outer and full regions and foveal avascular zone (FAZ) parameters (area, perimeter and circularity index) were compared between APAC, PACS, and control eyes. For resolved APAC eyes, the VD in each macular region was significantly lower than that in control eyes, with less central and inner macular VD than PACS eyes. The central macular VD was significantly lower in PACS eyes than in controls. There was no difference in FAZ area and perimeter between APAC, PACS, and control eyes. FAZ circularity was highest in control eyes, followed by PACS eyes, and lowest in APAC eyes. The AUC, sensitivity and specificity of FAZ circularity were 0.944, 93.9% and 84.8%, respectively, in APAC eyes and 0.881, 84.8% and 81.8%, respectively, in PACS eyes. Therefore, FAZ circularity had the best discrimination capability for detecting both APAC and PACS eyes. Macular assessment with OCTA could provide an accurate early-stage diagnostic tool for PACG.

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Section: Discussionmentioning

confidence: 99%

Macular vessel density and foveal avascular zone parameters in patients after acute primary angle closure determined by OCT angiography

Liu

Jiang

et al. 2020

Sci Rep

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“…However, studies have agreed that intraocular pressures up to 20 mmHg showed no impact on macular VD. 28,29 This may help to explain the intraocular and mean arterial pressure findings in the regression models. For example, an increase in mean arterial pressure correlated with a decrease in VD only in the macular region.…”

Section: Vessel Density (%)mentioning

confidence: 97%

Normative intercapillary distance and vessel density data in the temporal retina assessed by wide-field spectral-domain optical coherence tomography angiography

Liu

Guo

You

et al. 2021

Exp Biol Med (Maywood)

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A limitation of conventional optical coherence tomography angiography (OCTA) is the limited field of view normally used in data acquisition. As the technology improves, larger fields of view that capture information away from the macular are being explored in order to provide an enhanced ability to detect pathology. However, normative measurements for important OCTA metrics like vessel density and intercapillary distance are not currently well-characterized in the peripheral retina. In this prospective study, we measured vessel density and intercapillary distance of the superficial vascular complex, ganglion cell layer plexus, and deep capillary plexus in montaged macular/temporal scans from 53 (33 men) healthy volunteers. Vessel density and intercapillary distance were also compared across different regions of the retina, including along arcs at separate distance from the fovea. Compared to the central macular region, the temporal retina had significantly lower vessel density, decreased thickness, and greater intercapillary distance in the superficial vascular complex, GCLP ganglion cell layer plexus, and deep capillary plexus (Wilcoxon rank sum test P < 0.001), with each of the plexuses examined here showing a general decrease in vessel density and an increase in intercapillary distance towards the temporal region. No significant difference was noted comparing corresponding vessel density and intercapillary distance regions above and below the macula, and multiple linear regression showed that age and intraocular pressure were not associated with vessel density and intercapillary distance in most models. Repeatability analysis reported as intraclass correlation coefficients demonstrated moderate to excellent reliability of vessel density and intercapillary distance in all OCTA layers. These results should help provide an enhanced baseline to help identify vascular pathology in the peripheral retina.

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“…Snižováním NOT u mladých jedinců s vysokým NOT zaznamenal Holló zvýšení VD [23]. Obráceně, po jeho zvýšení nad 20 mmHg hustota cév v makule a peripapilárně významně poklesla [24].…”

Section: Diskuzeunclassified

OCT Angiography And Doppler Ultrasound In Hypertension Glaucoma

Lešták¹,

Fus²,

Benda³

et al. 2021

CSO

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Aims: The main aim of this work was to find out if there is a correlation between vessel density (VD) and results of measured perfusion values in ophthalmic artery and in central retinal artery of the same eye in a group with hypertension glaucoma (HTG). Materials and methods: The file included 20 patients with HTG, thereof 13 women of average age 68.7 years (49–80 years) and 7 men of average age 58.4 years (27–81 years). Criteria for inclusion in the study: visual acuity 1,0 with possible correction less than ±3 diopters, approximately the same changes in visual fields in every patient, intraocular pressure (IOP) less than 18 mmHg, no other ocular or neurological diseases. VD was measured by Avanti RTVue XR by Optovue firm, perfusion parameters were measured using Doppler ultrasound with Affinity 70G machine by Philips firm. The peak systolic velocity (PSV) and end diastolic velocity (EDV) and resistance index (RI) were measured both in ophthalmic artery (AO) and in central retinal artery (CRA). Visual field (VF) was examined by quick threshold glaucoma program by Medmont M 700 machine. The sum of sensitivities in apostilbs (abs) was evaluated in the range 0–22 degrees of visual field. The results of sensitivities in visual field were compared to VD and perfusion parameters in CRA and AO of the same eye. Results: Pearson’s correlation coefficient (p = 0,05) was used to assess the dependency between chosen parameters. By comparing VF and VD from measured areas, strong correlation (r = 0.64, resp. 0.65) was revealed. It was then proved that VD (WI-VDs) correlates with RICRA weakly (r = -0.35) and moderately strongly (WI-VDa r = -0.4, PP-VDs r = -0.43 and PP-VDa r = -0.45). This means that with increasing resistance index in CRA the density in VD decreases. The other correlations between VD and perfusion parameters (PSV and EDV) in CRA and AO were not significant. Conclusion: Measured values showed that the vascular component of VD has a huge impact on the changes in visual fields in HTG. Weak to moderate influence exists between VD and RI in CRA. OCTA has proven to be more suitable than Doppler ultrasound for determining the condition of blood circulation in the eye.

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Changes in Vessel Density of the Patients with Narrow Antenior Chamber after an Acute Intraocular Pressure Elevation Observed by OCT Angiography

Cited by 7 publications

References 25 publications

Macular vessel density and foveal avascular zone parameters in patients after acute primary angle closure determined by OCT angiography

Macular vessel density and foveal avascular zone parameters in patients after acute primary angle closure determined by OCT angiography

Normative intercapillary distance and vessel density data in the temporal retina assessed by wide-field spectral-domain optical coherence tomography angiography

OCT Angiography And Doppler Ultrasound In Hypertension Glaucoma

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