Located in the south of the Iberian Peninsula, the Doñana salt marshes occupy around half of Doñana National Park and are currently considered among the most important wetlands worldwide due to the importance of their ecosystem. In this research work, using a novel patented procedure, the effects of climate change on the study area between 2009 and 2020 were evaluated. For this reason, DEMs were downloaded from the 30-meter Shuttle Radar Topography Mission (SRTM). Furthermore, to check the depth of the flooded area, 792 satellite images (L5 TM, L7 ETM+, and L8 OLI) with a resolution of 30 m were analyzed. The results show how the combined use of geomatic techniques, such as radar, optical, and geographic information system (GIS) data, along with regression models and iterative processes, plays a key role in the prediction and analysis of the flooded area volume in the Doñana salt marshes. Another significant contribution of this work is the development of a new remote sensing index. In conclusion, given that the study area depends on its aquifers’ status, it would be advisable to implement policies aimed at eradicating illegal aquifer extraction, as well as recovery plans to avoid the complete clogging of this salt marsh.