2009
DOI: 10.1677/joe-09-0053
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Changes of agouti-related protein in hypothalamus, placenta, and serum during pregnancy in the rat

Abstract: Agouti-related protein (AGRP) is a homolog of the agouti protein and acts as an antagonist of peptides derived from propiomelanocortin through melanocortin receptors. This peptide is produced mainly in the hypothalamus, particularly during negative energy balance and influences increased food intake. In the hypothalamus, this peptide is co-expressed in arcuate nuclei with neuropeptide Y, another important peptide that regulates energy metabolisms. In our study, we analyzed changes in the Agrp mRNA level in the… Show more

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Cited by 6 publications
(6 citation statements)
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“…The only positive correlation we found between energy intake and the other peptides measured was with CSF AgRP. This finding suggests that AgRP is important in regulating energy expenditure and food intake during pregnancy and confirms findings in rodents . Since GWG decreases with maternal BMI, and the AgRP ratio increases with decreasing GWG in a BMI‐dependent manner, AgRP might counteract the inhibitory effects of insulin and leptin and thereby ensure that the energy demands of pregnant OB are met.…”
Section: Discussionsupporting
confidence: 84%
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“…The only positive correlation we found between energy intake and the other peptides measured was with CSF AgRP. This finding suggests that AgRP is important in regulating energy expenditure and food intake during pregnancy and confirms findings in rodents . Since GWG decreases with maternal BMI, and the AgRP ratio increases with decreasing GWG in a BMI‐dependent manner, AgRP might counteract the inhibitory effects of insulin and leptin and thereby ensure that the energy demands of pregnant OB are met.…”
Section: Discussionsupporting
confidence: 84%
“…The origin of circulating AgRP is still partly unknown; it is expressed in adrenal gland, testes, kidneys, and lungs in humans . In rodents, AgRP is expressed in placenta; its serum and CSF levels increase during pregnancy, and placenta is the main peripheral source . We found evidence for AgRP production in human placenta mirrored by increased serum levels during pregnancy.…”
Section: Discussionmentioning
confidence: 66%
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“…This indicates that central α-MSH resistance may be specific for pregnancy-induced hyperphagia. In contrast to α-MSH resistance during rat pregnancy, the production of NPY and AgRP is up-regulated during pregnancy in rats (Garcia et al 2003; Rocha et al 2003; Szczepankiewicz et al 2009). Although the exact mechanisms are unknown, it is plausible that these three neuropeptides are involved in the hyperphagia during pregnancy in the rat.…”
Section: Part I: Pregnancy and Food Intake Regulationmentioning
confidence: 99%
“…; Szczepankiewicz et al . ). In the present study, we observed that AgRP fibre density in the PVN was similar in pregnant and non‐pregnant animals.…”
Section: Discussionmentioning
confidence: 97%