Changes of Calmodulin, S-100 Protein .ALPHA./.BETA. and Keratin in Duct-Ligated Salivary Glands of Rats. An Immunohistochemical Study.

Jayasinghe, Neeta; Hashimoto, Junji; Ogata, Kazumasa; Shrestha, Pragya; Takai, Yoshiaki; Mori, Masahiko

doi:10.1267/ahc.26.555

Cited by 5 publications

(5 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Staining for the α-subunit was remarkable in the epithelium of striated and excretory ducts. These results are contrary to those of Haimoto et al (1987) who reported an inverse distribution in human glands, but confirmed observations of Jayasinghe et al (1993) and Molin et al (1984) who investigated rat salivary glands. Mori et al (1990) and Lee et al (1993) described S-100α-and βpositive serous cells in human major salivary glands but found the same distribution pattern of S-100 in the duct system as we did in bovine material.…”

Section: Discussionsupporting

confidence: 74%

“…Again, results indicated that myoepithelial cells in cattle do not react for S-100 or its subunits. In addition, rat myoepithelial cells were also found to be negative for S-100 (Jayasinghe et al 1993). In contrast, in dogs, S-100-positive myoepithelial cells were described in apocrine sweat glands (Ferrer et al 1990) and in mammary glands (Sandusky et al 1985), although Capellari (1996) could not confirm this latter finding (she used the same antibodies as we did).…”

Section: Discussionmentioning

confidence: 95%

“…Examination of exocrine glands from non-human species was carried out by Jayasinghe et al (1993) and Molin et al (1984) on salivary glands of rats and by Sandusky et al (1985) on mammary glands, pancreas, and apocrine sweat glands of dogs. The only study on bovine mammary tissue was performed by Momotani et al (1993) who found S-100α in secretory epithelium and myoepithelial cells.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Distribution of S-100 protein and its subunits in bovine exocrine glands

Lauboeck

Egerbacher²

1997

Histochemistry and Cell Biology

View full text Add to dashboard Cite

The distribution of S-100 protein and its alpha- and beta-subunits in bovine exocrine glands was studied by indirect immunohistochemistry. The entire spectrum of salivary glands, glands of the respiratory tract, intestinal glands, male and female genital glands, and skin glands was examined. S-100 and its beta-subunit were identified in most serous secretory cells of mixed salivary glands, although secretory acini in some serous glands remained unreactive for these antigens. Mucous cells were constantly negative; mucoid cells were positive in the lacrimal and Harderian gland. The alpha-subunit of S-100 protein was identified in serous cells but the staining reaction was faint. Subunits of S-100 showed a characteristic distribution along the excretory duct systems of compound glands: S-100 and the beta-subunit were present in intercalated duct epithelium, while striated duct epithelium stained for S100-alpha. Therefore, it is suggested that S100-alpha is related to resorption and secretion in striated ducts, while S100-beta may govern acinar exocytosis and probably regulates proliferation and differentiation of glandular cells. Differing staining intensities for S-100 and its subunits in secretory cells of exocrine glands most probably indicate functional differences with regard to secretory activity and the cell cycle.

show abstract

Section: Discussionsupporting

confidence: 74%

Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Distribution of S-100 protein and its subunits in bovine exocrine glands

Lauboeck

Egerbacher²

1997

Histochemistry and Cell Biology

View full text Add to dashboard Cite

show abstract

“…S100A1 is expressed in pillar and transition cells of the GCT segment and in striated duct of SMG of mice and rats (Hashimoto et al 1992a, b;Mori et al 1992;Jayasinghe et al 1993). Biological roles of S100 proteins are suggested to be the secretion of granules in granular cells and secretion of growth factors triggered by calcium signals.…”

Section: Discussionmentioning

confidence: 99%

“…It is well known that sex dimorphism in submandibular glands (SMG) of mice and rats are in accordance with the existence of GCTs, i.e., male SMG have well developed GCT segments while female SMG are not as developed (Gresik and Barka 1977;Barka 1980;Mori 1991;Mori et al 1993). Histological changes during postnatal development of the SMG show that GCT segments appear at 5-6 weeks of the postnatal period (Gresick and MacRae 1975).…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemical localization of S100A1 and S100A6 in postnatally developing salivary glands of rats

Mori

Yamada

Ohomura

et al. 1998

Histochemistry and Cell Biology

Self Cite

View full text Add to dashboard Cite

S100 proteins are calcium-binding proteins of the EF-hand superfamily and are involved in the regulation of a number of cellular processes. The present study deals with the immunohistochemical expression of S100A1 and S10100A6 in the rat submandibular and sublingual glands during postnatal development from day 0 to 12 weeks. Expression of S100A1 was particularly concentrated in pillar and transition cells in the granular convoluted tubule (GCT) and in striated duct cells of the submandibular gland age 4 weeks to maturity. None or only weak staining for S100A1 was observed in the duct segment at 0-5 days. On the contrary, immunostaining of S100A6 was present in proacinar cells in undifferentiated submandibular gland at age 3 days to 2 weeks. S100A6 immunoreactivity in rat submandibular gland coexisted with chromogranin reactivity. It is possible that S100A6 regulates secretion of chromogranin in proacinar cells. Secretion of growth factors and biologically active peptides in the GCT are regulated by calcium signals, and S100A1 may be involved in the secretory mechanism of granular cells. S100A1 and S100A6 are potentially of great importance in secretory functions of granular cells and proacinar cells, as well as in rat salivary glands.

show abstract

Sialadenitis

Seifert

1996

Oralpathologie I

View full text Add to dashboard Cite

Changes of Calmodulin, S-100 Protein .ALPHA./.BETA. and Keratin in Duct-Ligated Salivary Glands of Rats. An Immunohistochemical Study.

Cited by 5 publications

References 23 publications

Distribution of S-100 protein and its subunits in bovine exocrine glands

Distribution of S-100 protein and its subunits in bovine exocrine glands

Immunohistochemical localization of S100A1 and S100A6 in postnatally developing salivary glands of rats

Sialadenitis

Contact Info

Product

Resources

About