Changes of Circulating Lymphocyte Populations and Its Association with Outcome after Hypofractionated Radiation Therapy in Patients with Non-small-cell Lung Cancer

Abstract

considering RT history alone resulted in AUC of 0.63 (marginally significant), while the combination of RT history with texture features resulted in AUC of 0.86, a much stronger correlation with clinical outcome. The p-value for comparison of the two AUCs was 0.0017, indicating that the increase of AUC is statistically meaningful. Conclusion: This preliminary study suggests that texture features on pre-IT CT imaging can be associated with OS for patients with advanced NSCLC treated with Nivolumab, and that inclusion of pre-Nivolumab RT history improves model correlation with OS. Future directions include expansion of this study to the full database, correlation of texture features with molecular biomarkers, and assessment of RT timing and fractionation on treatment response.