Changes of complement and oxidative stress parameters in patients with acute cerebral infarction or cerebral hemorrhage and the clinical significance

Abstract

Changes of complement and oxidative stress parameters in patients with acute cerebral infarction (ACI) or cerebral hemorrhage (CH), and their clinical significance were explored. A total of 122 patients with ACI or CH admitted to the People's Hospital of Zhangqiu Area from August 2018 to September 2019 were collected. There were 59 ACI patients assigned into a cerebral infarction group (CIG) and further 63 CH patients in a cerebral hemorrhage group (CHG). Additionally, 53 healthy people in physical examination during the same period were enrolled as a control group (CG). Both the CIG and the CHG were treated with edaravone, Xueshuantong, brain protein hydrolysates, aspirin and statin-related drugs. The levels of complement C3, complement C4, superoxide dismutase (SOD), and total antioxidant capacity (TAC) were determined. Receiver operating characteristic (ROC) curves were employed to analyze the predictive value of C3, C4, SOD and TAG in ACI and CH, and logistic regression was used to analyze the risk factors of stroke. Both CIG and CHG showed higher C3 level, and lower C4, SOD and TAC levels than the CG. The NIHSS <4 group and the NIHSS ≥4 group showed higher hs-C3 level, and lower SOD and TAC levels than the CG (all P<0.05), and the NIHSS <4 group showed lower C3 level and lower SOD and TAC levels than the NIHSS ≥4 group (all P<0.05). Hypertension and hyperlipidemia were independent risk factors of stroke. The serum complement and oxidative stress parameters in patients with ACI or CH can be determined through routine examination, and the nerve function deficit could be assessed by determining the complement and oxidative stress parameters in clinical practice.

Mechanisms of Oxidative Stress and Therapeutic Targets following Intracerebral Hemorrhage

“…Studies have determined that the level of SOD in patients with cerebral hemorrhage (113.62 ± 9.14 U/mL) is significantly lower than healthy (161.20 ± 21.12 U/mL) [ 65 ]. It is a common indicator for evaluating oxidative stress in mouse models of ICH [ 2 , 6 , 56 , 58 , 66 , 67 ].…”

Role of complement C1q/C3-CR3 signaling in brain injury after experimental intracerebral hemorrhage and the effect of minocycline treatment

“…Current studies have revealed that there was a sixfold increase in C9 around the hematoma 24 h after ICH, and MAC and clusterin also increased in the perihematomal tissue 3 days after ICH ( 7 , 26 ).The anaphylatoxins C3a and C5a were upregulated after ICH: the level of C3a increased within 5 days after ICH, whereas the level of C5a peaked on day 3 and began to decrease ( 27 ). In a clinical study, patients with cerebral hemorrhage had higher C3 levels and lower C4 levels in serum than healthy people ( 28 ). Our study confirmed that the complement system and two complement pathways were upregulated after ICH at the transcriptive level in mouse brain tissue.…”

Xingnao Kaiqiao Acupuncture Combined with Butylphthalide Sodium Chloride Injection in the Treatment of Acute Cerebral Infarction and Its Effect on the Levels of Serum Malondialdehyde, Superoxide Dismutase, and Glutathione Peroxidase

“…Research shows that [16,17], oxidative stress runs through the whole pathogenesis of acute cerebral infarction. After brain injury and ischemia, a large number of free radicals are accumulated in cells.…”