Changes of CSF neuropeptides after environmental stimulation in dementia

Karlsson, Ingvar; Widerlöv, Erik; Melin, Else; Nyth, Anna-Lena; Bråne, Görel; Rybo, Elisabeth; Rehfeld, Jens F.; Bissette, Garth; Nemeroff, Charles B.

doi:10.3109/08039488509101961

Cited by 25 publications

(10 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are limitations in this study, such as the small sample size and an absence of power calculation, due to practical reasons and the pilot study (Karlsson et al 1985). Moreover, the food intake was not weighed or recorded, the sample size was small but the positive results are suggested to be reliable as they are in line with the results from other results in the main project.…”

Section: Discussionmentioning

confidence: 87%

“…There are limitations in this study, such as the small sample size and an absence of power calculation, due to practical reasons and the pilot study (Karlsson et al. 1985).…”

Section: Discussionmentioning

confidence: 99%

“…The study was performed in two wards in different nursing homes. Consideration about the sample size was a previous pilot study (Karlsson et al 1985). Nursing homes in the area were asked to participate.…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Weight increase in patients with dementia, and alteration in meal routines and meal environment after integrity promoting care

MSc¹,

Karlsson²,

Norberg³

et al. 2007

Journal of Clinical Nursing

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 87%

“…There are limitations in this study, such as the small sample size and an absence of power calculation, due to practical reasons and the pilot study (Karlsson et al. 1985).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Weight increase in patients with dementia, and alteration in meal routines and meal environment after integrity promoting care

MSc¹,

Karlsson²,

Norberg³

et al. 2007

Journal of Clinical Nursing

Self Cite

View full text Add to dashboard Cite

show abstract

“…[6]. This method has been vali dated by gas chromatography-mass spectrometry [15] and has been found to have similar imprecision as the assay described by Balldin et al [6].…”

Section: Dexamethasone Suppression Testmentioning

confidence: 96%

Relationship between Mental Impairment and HPA Axis Activity in Dementia Disorders

Balldin¹,

Blennow²,

Bråne³

et al. 1994

Dement Geriatr Cogn Disord

Self Cite

View full text Add to dashboard Cite

In 40 patients with Alzheimer's disease (AD, <65 years), 56 patients with senile dementia of the Alzheimer type (SDAT, ≥65 years) and 45 patients with vascular dementia (VAD), basal cortisol levels were estimated and the dexamethasone test (DST) was performed. The degree of dementia was assessed according to DSM-III-R and the GBS scale was used for quantitative measures of functional impairment. There were no significant differences in basal cortisol levels. Especially in the VAD group, scores on functional impairment correlated significantly with post-DST cortisol levels. The results indicate hypothalamic overactivity in demented patients which can be correlated to the degree of dementia. In VAD, and to a certain extent also in SDAT, there appears to be a disconnection between cortical areas, including the hippocampus and the hypothalamus.

show abstract

“…Karlsson et al (58) and Widerlov et al (59) found that patients with Alzheimer's disease exposed to intensive environmental stimulation showed increase in CSF somatostatin concentration and reversal of dementia symptoms when compared with demented control patients who received more traditional care. The environment has not yet been considered as a major contributing factor in the etiology and pathogenesis of dementia.…”

Section: Alzheimer's Disease and Somatostatinmentioning

confidence: 99%

Brain and CSF somatostatin concentrations in patients with psychiatric or neurological illness An overview

Vécsei

Widerlöv

1988

Acta Psychiatr Scand

View full text Add to dashboard Cite

Somatostatin was originally isolated as a 14-amino-acid peptide from the ovine hypothalamus. The peptide has a widespread regional distribution within the central and peripheral nervous systems, as well as in peripheral organs. Preservation of the chemical structure over a wide range of vertebral species indicates important functional roles of the peptide. Recent results about the role of somatostatin and related peptides in different psychiatric (depression, schizophrenia, Alzheimer's disease) and neurological (Huntington's disease, multiple sclerosis, Parkinson's disease) diseases, and the effects on the hypothalamic-pituitary-adrenal axis are summarized. Also, the influence of some psychotropic drugs (halo-peridol, carbamazepine) on somatostatin levels in cerebrospinal fluid is discussed.

show abstract

Changes of CSF neuropeptides after environmental stimulation in dementia

Cited by 25 publications

References 17 publications

Weight increase in patients with dementia, and alteration in meal routines and meal environment after integrity promoting care

Weight increase in patients with dementia, and alteration in meal routines and meal environment after integrity promoting care

Relationship between Mental Impairment and HPA Axis Activity in Dementia Disorders

Brain and CSF somatostatin concentrations in patients with psychiatric or neurological illness An overview

Contact Info

Product

Resources

About