Changes of Duodenal pH and Pancreatic Exocrine Function after Upper G-I Intraluminal Ethanol Administration.

Abstract

of Duodenal pH and Pancreatic Exocrine Function after Upper G-I Intraluminal Ethanol Administration. Tohoku J. Exp. Med., 1991, 164 (1), [81][82][83][84][85][86][87][88][89][90][91] Using 3 outbred dogs with pancreatic, gastric and jejunal fistulas, we examined changes in pancreatic exocrine secretion, duodenal pH and plasma CCK concentration after intragastric or intrajejunal administration of ethanol. Intragastric administration of 20% or 40% ethanol significantly lowered the pH in the duodenal cavity, and pancreatic fluid secretion and bicarbonate excretion were stimulated. Intrajejunal administration of ethanol elicited stronger responses. Plasma CCK concentration was not changed or was only slightly lowered by ethanol administration in the digestive tract. It is assumed that stimulation of pancreatic exocrine secretion was mediated by the secretion of gastric acid.gastrointestinal administration of ethanol ; duodenal pH ; pancreatic exocrine function Many studies have been conducted to present the action of ethanol on exocrine secretion of the pancreas. It has been reported that oral administration of ethanol causes elevation in pancreatic exocrine secretion (Brooks and Thomas 1952: Walton et al. 1962;Llanos 1977). There are also contrasting reports that pancreatic exocrine secretion is suppressed (Dreiling et al. 1952;Tiscornia et al. 1973), and stimulated (Walton et al. 1962) by intravenous administration of ethanol. Noel-Jorand and Sarles (1983) reported that suppressive and stimulative effects exist in accordance with high and low blood ethanol concentration.However, there appeared to be no reports of studies that have continuously measured variations of the duodenal luminal pH in response to gastrointestinal administration of ethanol. In our study, we simultaneously measured duodenal lumen pH and pancreatic exocrine secretion to determine the effects of gastrointes-

Spirits and Gastrectomy Increase Risk for Chronic Pancreatitis in Japanese Male Alcoholics

“…Reports on the consumption of high-alcohol drinks and the risk for chronic illnesses (17)(18)(19)(20)(21)(22)(23)(24)(25) led us to speculate that (1) in persons who drink high-alcohol beverages, some mechanism other than total grams of ethanol consumed increases the risk for organ injury; (2) low-alcohol beverages (3) something contained in lower-alcohol beverages offers some protection to internal organs. Aside from the direct effects of high or low alcohol content, most recent ecological studies have suggested that wine is effective in reducing the risk of mortality from heart disease because of its antioxidant content (26).…”

The Ethanol-Induced Stimulation of Rat Duodenal Mucosal Bicarbonate Secretion In Vivo Is Critically Dependent on Luminal Cl–

“…Recent experiments from our laboratory showed that a short duodenal exposure (30 min) of 15% alcohol by volume (ABV) induce low-grade morphological changes in only a small number of duodenal villi tips in rats [5]. Additionally, ethanol induces dysmotility, increases duodenal epithelial paracellular permeability, and stimulates gastric acid secretion as well as pancreatic exocrine secretion [6], [7], [8], [9].…”