Changes of endocrine function of adipose tissue in anorexia nervosa: comparison of circulating levels versus subcutaneous mRNA expression

Doležalová, R; Lacinová, Z; Dolinkova, Marketa; Kleiblová, Petra; Haluzíková, D; Housa, Daniel; Papežová, Hana; Haluzı́k, Martin

doi:10.1111/j.1365-2265.2007.02944.x

Cited by 65 publications

(52 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Serum adiponectin has been found to be either increased Pannacciulli et al, 2003), normal (Iwahashi et al, 2003) or decreased (Tagami et al, 2004) in AN patients. Likewise, serum plasma resistin levels have been found to be either decreased (Dostalova et al, 2006) or normal (Dolezalova et al, 2007). These discrepancies suggest that some confounding factors, such as eating behaviors and/or physical activity level, could interfere with the results.…”

Section: Introductionmentioning

confidence: 87%

Specific adipocytokines profiles in patients with hyperactive and/or binge/purge form of anorexia nervosa

et al. 2010

View full text Add to dashboard Cite

Objective: The aim of our study was to determine whether eating behaviors and/or physical activity level may explain contradicting results in adipocytokines levels in anorexia nervosa (AN). Subjects/Methods: Fasting levels of circulating adipocytokines (adiponectin, resistin and leptin), insulin, glucose, C-reactive protein, cytokines (tumor necrosis factor-a and interleukin (IL)-1b), body composition and resting energy expenditure were measured in 24 women AN patients and 14 women controls. These parameters were compared according to AN subtypes: 15 patients with restrictive (R-AN) form versus 9 patients with binge/purge (BP-AN) form; 15 patients with hyperactive (H-AN) form versus 9 patients with nonhyperactive (NH-AN) form. Results: BP-AN patients had significantly higher serum adiponectin levels compared with R-AN patients (Po0.05), and H-AN patients had higher serum leptin and lower serum resistin levels compared with NH-AN patients (Po0.05 for both). Conclusions: Our study shows specific adipocytokines profiles depending on the subtype of AN: restrictive versus binge/purge and hyperactive versus Nonhyperactive forms. We suggest that these biological signatures could interfere with the outcome of the disease.

show abstract

Section: Introductionmentioning

confidence: 87%

Specific adipocytokines profiles in patients with hyperactive and/or binge/purge form of anorexia nervosa

et al. 2010

View full text Add to dashboard Cite

show abstract

“…by short-term caloric restriction or in the first weeks after a bariatric procedure (Mraz et al 2011, Trachta et al 2014. Moreover, subjects with severely depleted fat reserves as seen in mental anorexia also show increased production of proinflammatory adipokines (Dolezalova et al 2007). These data suggest that rapid or extreme changes in body fat content provoke immune response regardless of their direction.…”

Section: At As Immune Organmentioning

confidence: 97%

The role of adipose tissue immune cells in obesity and low-grade inflammation

Mráz

Haluzı́k

2014

Journal of Endocrinology

Self Cite

459

323

View full text Add to dashboard Cite

Adipose tissue (AT) lies at the crossroad of nutrition, metabolism, and immunity; AT inflammation was proposed as a central mechanism connecting obesity with its metabolic and vascular complications. Resident immune cells constitute the second largest AT cellular component after adipocytes and as such play important roles in the maintenance of AT homeostasis. Obesity-induced changes in their number and activity result in the activation of local and later systemic inflammatory response, marking the transition from simple adiposity to diseases such as type 2 diabetes mellitus, arterial hypertension, and ischemic heart disease. This review has focused on the various subsets of immune cells in AT and their role in the development of AT inflammation and obesity-induced insulin resistance.

show abstract

“…The cross-sectional design and other limitations of our study do not allow us to directly support this conclusion. Nevertheless, we have previously demonstrated that local changes in mRNA expression of some of the proinflammatory cytokines in subcutaneous adipose tissue of malnourished patients with anorexia nervosa share some similarities with changes in patients with obesity suggesting that local inflammatory response is present in adipose tissue of both cachectic and obese patients (21,22). Here, we showed that 2 weeks of VLCD did not significantly change serum MIC-1 levels in obese women with T2DM, but it significantly reduced serum MIC-1 in obese women without T2DM in spite of a similar reduction of body weight, serum cholesterol, serum triglycerides, and serum CRP during VLCD in both groups of patients.…”

Section: Discussionmentioning

confidence: 99%

Increased serum concentrations of macrophage inhibitory cytokine-1 in patients with obesity and type 2 diabetes mellitus: the influence of very low calorie diet

Dostálová

Roubíček²,

Bartlova³

et al. 2009

European Journal of Endocrinology

148

140

View full text Add to dashboard Cite

Objective: Macrophage inhibitory cytokine-1 (MIC-1) is a novel regulator of energy homeostasis. We explored whether alterations in MIC-1 levels contribute to metabolic disturbances in patients with obesity and/or obesity and type 2 diabetes mellitus (T2DM). Design: We measured serum MIC-1 levels and its mRNA expression in subcutaneous and visceral adipose tissue of 17 obese nondiabetic women, 14 obese women with T2DM and 23 healthy lean women. We also explored the relationship of MIC-1 with anthropometric and biochemical parameters and studied the influence of 2-week very low calorie diet (VLCD) on serum MIC-1 levels. Methods: Serum MIC-1 levels were measured by ELISA and its mRNA expression was determined by RT-PCR. Results: Both obese and T2DM group had significantly elevated serum MIC-1 levels relative to controls. T2DM group had significantly higher serum MIC-1 levels relative to obese group. Serum MIC-1 positively correlated with body weight, body fat, and serum levels of triglycerides, glucose, HbAlc, and C-reactive protein and it was inversely related to serum high-density lipoprotein cholesterol. Fat mRNA MIC-1 expression did not significantly differ between lean and obese women but it was significantly higher in subcutaneous than in visceral fat in both groups. VLCD significantly increased serum MIC-1 levels in obese but not T2DM group. Conclusion: Elevated MIC-1 levels in patients with obesity are further increased by the presence of T2DM. We suggest that in contrast to patients with cancer cachexia, increased MIC-1 levels in obese patients and diabetic patients do not induce weight loss.

show abstract

Changes of endocrine function of adipose tissue in anorexia nervosa: comparison of circulating levels versus subcutaneous mRNA expression

Abstract: Local perturbations in resistin, adiponectin and interleukin-6 mRNA expression in subcutaneous adipose tissue are not reflected by its circulating levels. These changes could be involved in some local metabolic disturbances in subcutaneous adipose tissue of anorexia nervosa patients.

Cited by 65 publications

References 33 publications

Specific adipocytokines profiles in patients with hyperactive and/or binge/purge form of anorexia nervosa

Specific adipocytokines profiles in patients with hyperactive and/or binge/purge form of anorexia nervosa

The role of adipose tissue immune cells in obesity and low-grade inflammation

Increased serum concentrations of macrophage inhibitory cytokine-1 in patients with obesity and type 2 diabetes mellitus: the influence of very low calorie diet

Contact Info

Product

Resources

About