Changes of energy metabolism in failing heart and its regulation by SIRT3

Wang, Xiao; Huang, Yuting; Zhang, Kai; Chen, Feng; Nie, Tong; Zhao, Yun; He, Feng; Ni, Jingyu

doi:10.1007/s10741-023-10295-5

Cited by 6 publications

(3 citation statements)

References 176 publications

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“…Energy abnormalities in the heart are associated with the development of many heart diseases (X. Wang et al, 2023 ). Heat stress disrupts the integrity of the mitochondria, which is the basis for normal mitochondrial function, resulting in a suppression of energy production from the oxidative metabolism of cardiomyocytes ( Patra and Hay, 2014 ; Laitano et al, 2020 ; Deng et al, 2022 ).…”

Section: The Related Mechanisms Of Hs-induced Myocardial Injurymentioning

confidence: 99%

The pathogenesis and therapeutic strategies of heat stroke-induced myocardial injury

Xia,

Sun,

et al. 2024

Front. Pharmacol.

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Heat stroke (HS) is a febrile illness characterized by an elevation in the core body temperature to over 40°C, accompanied by central nervous system impairment and subsequent multi-organ dysfunction syndrome. In recent years, the mortality rate from HS has been increasing as ambient temperatures continue to rise each year. The cardiovascular system plays an important role in the pathogenesis process of HS, as it functions as one of the key system for thermoregulation and its stability is associated with the severity of HS. Systemic inflammatory response and endothelial cell damage constitute pivotal attributes of HS, other factors such as ferroptosis, disturbances in myocardial metabolism and heat shock protein dysregulation are also involved in the damage to myocardial tissue in HS. In this review, a comprehensively detailed description of the pathogenesis of HS-induced myocardial injury is provided. The current treatment strategies and the promising therapeutic targets for HS are also discussed.

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Section: The Related Mechanisms Of Hs-induced Myocardial Injurymentioning

confidence: 99%

The pathogenesis and therapeutic strategies of heat stroke-induced myocardial injury

Xia,

Sun,

et al. 2024

Front. Pharmacol.

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“…The main source of ATP supply in cardiac cells is the OxPho, which provides 95% of cardiomyocytes' ATP requirements mainly through energy metabolism of substrates such as fatty acids (50%), pyruvate, ketone, and amino acids. The remaining 5% of ATP is generated through glycolysis [49,50].…”

Section: Mitochondrial Metabolism: Heart Function and Cardiac Failurementioning

confidence: 99%

Beneficial Effects of Halogenated Anesthetics in Cardiomyocytes: The Role of Mitochondria

Guerrero-Orriach,

Carmona-Luque,

Raigón-Ponferrada

2023

Antioxidants

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In the last few years, the use of anesthetic drugs has been related to effects other than those initially related to their fundamental effect, hypnosis. Halogenated anesthetics, mainly sevoflurane, have been used as a therapeutic tool in patients undergoing cardiac surgery, thanks to the beneficial effect of the cardiac protection they generate. This effect has been described in several research studies. The mechanism by which they produce this effect has been associated with the effects generated by anesthetic preconditioning and postconditioning. The mechanisms by which these effects are induced are directly related to the modulation of oxidative stress and the cellular damage generated by the ischemia/reperfusion procedure through the overexpression of different enzymes, most of them included in the Reperfusion Injury Salvage Kinase (RISK) and the Survivor Activating Factor Enhancement (SAFE) pathways. Mitochondria is the final target of the different routes of pre- and post-anesthetic conditioning, and it is preserved from the damage generated in moments of lack of oxygen and after the recovery of the normal oxygen concentration. The final consequence of this effect has been related to better cardiac function in this type of patient, with less myocardial damage, less need for inotropic drugs to achieve normal myocardial function, and a shorter hospital stay in intensive care units. The mechanisms through which mitochondrial homeostasis is maintained and its relationship with the clinical effect are the basis of our review. From a translational perspective, we provide information regarding mitochondrial physiology and physiopathology in cardiac failure and the role of halogenated anesthetics in modulating oxidative stress and inducing myocardial conditioning.

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“…Mammalian sirtuins (SIRT1-7), a family of deacetylases, are mainly active through nicotinamide adenine dinucleotides (NAD), among which SIRT3 is mainly expressed in mitochondria. 16 , 17 SIRT3 can regulate a variety of processes, such as energy homeostasis, REDOX balance, mitochondrial quality control, mitochondrial biogenesis, kinetics and mitochondrial autophagy. 18 , 19 SIRT3 can participate in the progression of AF by restructuring mitochondrial function.…”

Section: Introductionmentioning

confidence: 99%

Resveratrol mediates mitochondrial function through the sirtuin 3 pathway to improve abnormal metabolic remodeling in atrial fibrillation

Cao,

Cui,

Tuo

et al. 2024

Eur J Histochem

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This study investigated the impact of resveratrol on abnormal metabolic remodeling in atrial fibrillation (AF) and explored potential molecular mechanisms. An AF cell model was established by high-frequency electrical stimulation of HL-1 atrial muscle cells. Resveratrol concentrations were optimized using CCK-8 and flow cytometry. AF-induced increases in ROS and mitochondrial calcium, along with decreased adenosine triphosphate (ATP) and mitochondrial membrane potential, were observed. Resveratrol mitigated these changes and maintained normal mitochondrial morphology. Moreover, resveratrol acted through the SIRT3-dependent pathway, as evidenced by its ability to suppress AF-induced acetylation of key metabolic enzymes. SIRT3 overexpression controls acetylation modifications, suggesting its regulatory role. In conclusion, resveratrol's SIRT3-dependent pathway intervenes in AF-induced mitochondrial dysfunction, presenting a potential therapeutic avenue for AF-related metabolic disorders. This study sheds light on the role of resveratrol in mitigating AF-induced mitochondrial remodeling and highlights its potential as a novel treatment for AF.

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Changes of energy metabolism in failing heart and its regulation by SIRT3

Cited by 6 publications

References 176 publications

The pathogenesis and therapeutic strategies of heat stroke-induced myocardial injury

The pathogenesis and therapeutic strategies of heat stroke-induced myocardial injury

Beneficial Effects of Halogenated Anesthetics in Cardiomyocytes: The Role of Mitochondria

Resveratrol mediates mitochondrial function through the sirtuin 3 pathway to improve abnormal metabolic remodeling in atrial fibrillation

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