Changes of energy metabolism, nutritional status and serum cytokine levels in patients with Crohn’s disease after anti-tumor necrosis factor-α therapy

Nishida, Nao; Sasaki, Makoto; Kurihara, Mika; Ichimaru, Satomi; Wakita, Maki; Bamba, Shigeki; Andoh, Akira; Fujiyama, Yoshihide; Amagai, Teruyoshi

doi:10.3164/jcbn.13-18

Cited by 8 publications

(11 citation statements)

References 32 publications

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“…Previous studies have reported improvements in nutritional status and metabolism after infliximab therapy but did not measure vitamin D levels per se. 29,30 …”

Section: Discussionmentioning

confidence: 99%

Vitamin D Levels in Adults with Crohnʼs Disease Are Responsive to Disease Activity and Treatment

Ham

Longhi

Lahiff

et al. 2014

Inflammatory Bowel Diseases

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Background Vitamin D deficiency is common in patients with Crohn’s disease (CD), although whether this impairs immune responsiveness, and is related to disease activity per se, remains unclear. We sought to investigate vitamin D pathways in patients with CD according to measures of inflammation and immune response. Methods Prospectively collected samples of a well-characterized cohort of patients with CD were used to measure serum 25(OH)-vitamin D levels by enzyme-linked immunoassay. Related gene expression was determined by polymerase chain reaction in T cells. The effect of vitamin D on the proliferation of isolated CD4+ cells was determined. Results Patients with active CD had lower serum vitamin D levels than those in clinical remission; this measurement was independent of season or reported use of vitamin D supplements. Harvey–Bradshaw Index scores, but not C-reactive protein, correlated with serum vitamin D levels. Gene expression of the vitamin D receptor was higher in peripheral blood T cells from patients with active disease than in those in remission. The proportion of CD25hi CD4+ cells from patients with CD increased in the presence of vitamin D. After treatment with infliximab, significant increases in serum vitamin D levels were noted in patients. Conclusions Low vitamin D levels are associated with disease activity in CD and increase after infliximab treatment.

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“…Previous studies have reported improvements in nutritional status and metabolism after infliximab therapy but did not measure vitamin D levels per se. 29,30 …”

Section: Discussionmentioning

confidence: 99%

Vitamin D Levels in Adults with Crohnʼs Disease Are Responsive to Disease Activity and Treatment

Ham

Longhi

Lahiff

et al. 2014

Inflammatory Bowel Diseases

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“…We previously reported that anti-TNF-α therapy did not affect mREE but significantly increased the RQ in adult CD patients. ( 16 ) However, the relationship between energy expenditure and disease activity in adult UC patients remains unclear, although we previously reported a significant correlation between mREE and the Lichtiger index. ( 15 )…”

Section: Discussionmentioning

confidence: 93%

“…Recently, we evaluated the changes in the energy metabolism of CD patients receiving anti-tumor necrosis factor (TNF)-α therapy and showed that anti-TNF-α therapy significantly increased the RQ but did not affect the mREE. ( 16 ) These results suggested that the principal metabolic substrate might shift from fat to carbohydrate oxidation after anti-TNF-α therapy. However, there are no reports about metabolic changes due to medical treatment in UC patients.…”

Section: Introductionmentioning

confidence: 89%

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Changes in energy metabolism after induction therapy in patients with severe or moderate ulcerative colitis

Inoue

Sasaki

Takaoka

et al. 2015

J. Clin. Biochem. Nutr.

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We investigated the changes in energy expenditure during induction therapy in patients with severe or moderate ulcerative colitis. Thirteen patients (10 men, 3 women; mean age, 36.5 years) with ulcerative colitis admitted to the Shiga University Hospital were enrolled in this study. We measured the resting energy expenditure and respiratory quotients of these patients before and after induction therapy with indirect calorimetry. We analyzed the changes of nutritional status and serum inflammatory cytokine levels and also evaluated the relationship between energy metabolism and disease activity by using the Seo index and Lichtiger index. The resting energy expenditure was 26.3 ± 3.8 kcal/kg/day in the active stage and significantly decreased to 23.5 ± 2.4 kcal/kg/day after induction therapy (p<0.01). The resting energy expenditure changed in parallel with the disease activity index and C-reactive protein and inflammatory cytokine levels. The respiratory quotient significantly increased after induction therapy. Thus, moderate to severe ulcerative colitis patients had a hyper-metabolic status, and the energy metabolism of these patients significantly changed after induction therapy. Therefore, we recommend that nutritional management with 30–34 kcal/kg/day (calculated as measured resting energy expenditure × activity factor, 1.3) may be optimal for hospitalized ulcerative colitis patients.

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“…20 The selection of a proper therapy, such as biological therapy, which is used with increasing frequency, seems not only to mitigate the inflammatory process in the gastrointestinal (GI) tract, but also to provide beneficial effects on the nutritional status of patients with CD, thus denoting the increasing importance of medications in vitamins and micronutrient levels. 21 Taken together current evidence suggests that vitamins might play an important role for the disease course and outcome of IBD patients. It is of great importance to gain a deeper understanding about vitamin and iron status via regular nutritional monitoring in IBD patients.…”

Section: Introductionmentioning

confidence: 92%

The Relevance of Vitamin and Iron Deficiency in Patients with Inflammatory Bowel Diseases in Patients of the Swiss IBD Cohort

Madanchi

Fagagnini

Fournier

et al. 2018

Inflammatory Bowel Diseases

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Background andAims: Vitamin and iron deficiencies are common in patients with inflammatory bowel disease (IBD) as a result of chronic intestinal inflammation, increase in demand, or dietary restrictions. Here, we assessed the frequency of complications in relation to deficiency of iron, folate acid, and vitamin B12 in patients enrolled in the nationwide Swiss Inflammatory Bowel Disease Cohort Study (SIBDCS). Methods: A total of 2666 patients were included in the study, 1558 with Crohn's disease (CD) and 1108 with ulcerative colitis (UC). Results: Iron deficiency anemia was detected in 19.6% of CD patients and 21.6% of UC patients. In CD patients low BMI and nonsmoker status were positively associated with anemia. In both CD and UC, malabsorption syndrome, defined as failure of the GI tract to absorb 1 or more substances from the diet, was found to be significantly associated with anemia (6.2% and 3.8%, respectively) and current steroid use (40% CD, 52.7% UC). In CD patients with ileal (31.7% vs 20%) and colonic (29.9% vs 25%) disease location folate deficiency was significantly higher than in patients with ileocolonic CD or upper GI involvement. In CD patients, vitamin B12 deficiency was associated with the onset of stenosis and intestinal surgery (42.9% vs 32.8% and 46% vs 33% for patients with versus without B12 deficiency). Conclusion: Our data indicate that due to frequent occurrence of deficiency states, regular monitoring and substitution of vitamins and iron are mandatory and may prevent long-term intestinal and extraintestinal complications in IBD patients.

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Changes of energy metabolism, nutritional status and serum cytokine levels in patients with Crohn’s disease after anti-tumor necrosis factor-α therapy

Cited by 8 publications

References 32 publications

Vitamin D Levels in Adults with Crohnʼs Disease Are Responsive to Disease Activity and Treatment

Vitamin D Levels in Adults with Crohnʼs Disease Are Responsive to Disease Activity and Treatment

Changes in energy metabolism after induction therapy in patients with severe or moderate ulcerative colitis

The Relevance of Vitamin and Iron Deficiency in Patients with Inflammatory Bowel Diseases in Patients of the Swiss IBD Cohort

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