Changes of epidural blood flow after epidural administration of epinephrine in young rats

Abukawa, Yukako; Kakibana, Manabu; Hiroki, Koichi; Sugawara, Kazuhiro; Ozaki, Makoto

doi:10.1111/pan.12737

Cited by 1 publication

(1 citation statement)

References 11 publications

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“…This finding is consistent with our study showing an increase in the first-minute heart rate among children in the study group compared to the control group. In a survey conducted by Abukawa et al on rats, the administration of epinephrine into the epidural space was safe in young rats (18), which is consistent with the results of our study. Our findings are compatible with the results of Deng et al, showing the stability of hemodynamic variables during caudal anesthesia with bupivacaine and epinephrine-added bupivacaine in new-borns (19).…”

Section: Discussionsupporting

confidence: 93%

Cardiovascular Effects of Adding Epinephrine to Bupivacaine in Children Undergoing Caudal Block: A Double-blind Randomized Clinical Trial

Seyedhejazi

Karami

2022

Interv Pain Med Neuromod

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Background: Caudal block is a common, safe, and effective anesthetic technique for lower abdominal, urological, and lower extremity surgeries in pediatrics. Objectives: This study aimed to evaluate the cardiovascular effects of adjuvant epinephrine in the caudal block on heart rate and blood pressure changes in children. Methods: This double-blind, randomized clinical trial was performed on 60 children who underwent elective infra-umbilical surgeries. They were under general anesthesia with midazolam, fentanyl, lidocaine, and propofol. The patients were ventilated through laryngeal mask airway (LMA), and anesthesia was maintained with sevoflurane in O2 and N2O mixture. The intervention group received a caudal block with 0.2% bupivacaine and 1/200000 epinephrine (1 mL/kg), while the control group received a caudal block without epinephrine. Heart rate, blood pressure, and ECG were monitored before the block and in the first, fifth, and 20th minutes after surgery. Results: The two groups showed no statistically significant differences in demographics and systolic and diastolic blood pressures. However, sinus arrhythmia was more prevalent in the study group in the first minute after the block (P < 0.001). No differences were observed in the incidence of arrhythmia in the fifth and 20th minutes after the block. Conclusions: It appears that epinephrine as an adjuvant to the caudal block does not have long-lasting effects after the block, except sinus tachycardia in the first minute. Considering that no changes in blood pressure and other hemodynamic parameters were observed, it seems that epinephrine can be used safely in the caudal block in pediatric patients.

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Section: Discussionsupporting

confidence: 93%

Cardiovascular Effects of Adding Epinephrine to Bupivacaine in Children Undergoing Caudal Block: A Double-blind Randomized Clinical Trial

Seyedhejazi

Karami

2022

Interv Pain Med Neuromod

View full text Add to dashboard Cite

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Changes of epidural blood flow after epidural administration of epinephrine in young rats

Abstract: Administration of epinephrine into the epidural space was safe in young rats. While reduction of epidural blood flow was observed, there was no spinal ischemia.

Cited by 1 publication

References 11 publications

Cardiovascular Effects of Adding Epinephrine to Bupivacaine in Children Undergoing Caudal Block: A Double-blind Randomized Clinical Trial

Cardiovascular Effects of Adding Epinephrine to Bupivacaine in Children Undergoing Caudal Block: A Double-blind Randomized Clinical Trial

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