Changes of fractional anisotropy (FA) and apparent diffusion coefficient (ADC) in the model of experimental acute hydrocephalus in rabbits

Shevtsov, Maxim; Senkevich, Konstantin; Kim, Aleksandr; Gerasimova, Kseniia A.; Trofimova, T. N.; Kataeva, G. V.; Медведев, С. В.; Smirnova, Olga I.; Савинцева, Жанна Игоревна; Martynova, Marina G.; Bystrova, Olga V.; Pitkin, Emil; Yukina, G. Yu.; Khachatryan, W. А.

doi:10.1007/s00701-014-2339-7

Cited by 6 publications

(7 citation statements)

References 42 publications

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“…In previous studies, a chronic hypoxic environment caused by hydrocephalus has been demonstrated [ 17 , 18 , 20 ]. Researchers considered that the diffusion values calculated in basal ganglia areas could be conditioned mainly by the chronic hypoxic environment causing cytotoxic damage [ 25 , 26 , 33 ], as opposed to what happens in the periventricular areas where the mechanism underlying the chronic damage of the white matter is mainly induced by the interstitial trans-ependymal edema.…”

Section: Discussionmentioning

confidence: 99%

The role of perfusion and diffusion MRI in the assessment of patients affected by probable idiopathic normal pressure hydrocephalus. A cohort-prospective preliminary study

Tuniz

Vescovi

Bagatto

et al. 2017

Fluids Barriers CNS

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BackgroundInvasive tests measuring resistance to cerebral spinal fluid (CSF) outflow and the effect of temporary drainage of CSF are used to select candidates affected by idiopathic normal pressure hydrocephalus (iNPH) for shunt surgery. Neither test, however, completely excludes patients from treatment. Perfusion and diffusion magnetic resonance imaging (MRI) are non-invasive techniques that might be of value in selecting patients for surgical treatment and understanding brain changes in iNPH patients. The aim of this study was to understand the role of perfusion and diffusion MRI in selecting candidates for shunt surgery and to investigate the relationship between cerebral perfusion and possible microstructural changes in brain tissue before and after invasive tests, and after ventricular-peritoneal (VP) shunt implantation, to better clarify pathophysiological mechanisms underlying iNPH.MethodsTwenty-three consecutive patients with probable iNPH were included in this study. Patients underwent a clinical and neuroradiological evaluation before and after invasive tests, and after surgery. Only patients who showed a positive result in at least one of the invasive tests were submitted for VP shunt implantation. Perfusion and diffusion magnetic resonance imaging (MRI) was performed before and after invasive tests and after shunt surgery.ResultsThirteen patients underwent surgery and all showed clinical improvement after VP shunt implantation and a significant increase in perfusion in both periventricular white matter (PVWM) and basal ganglia (BG) regions. The 10 patients that did not have surgery showed after invasive tests, a significant reduction in perfusion in both PVWM and BG regions. Comparing the changes in perfusion with those of diffusion in positive patients we found a significant positive correlation in BG and a significant inverse correlation in PVWM area.ConclusionsPerfusion MRI is a non-invasive technique that could be useful together with invasive tests in selecting patients for surgical treatment. Furthermore, the relationship between perfusion and diffusion data could better clarify pathophysiological mechanisms underlying iNPH. In PVWM area we suggest that interstitial edema could reduce microvascular blood flow and interfere with the blood supply to these regions. In BG regions we suggest that a chronic hypoxic insult caused by blood hypo-perfusion produces a chronic cytotoxic edema. Both in PVWM and in BG regions, pathophysiological mechanisms could be modified after VP-shunt implantation.

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Section: Discussionmentioning

confidence: 99%

The role of perfusion and diffusion MRI in the assessment of patients affected by probable idiopathic normal pressure hydrocephalus. A cohort-prospective preliminary study

Tuniz

Vescovi

Bagatto

et al. 2017

Fluids Barriers CNS

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“…At the same time, it is very important to distinguish situations when the ventricles are smaller than usual, or even almost invisible, but the clinical picture is asymptomatic and hence surgical correction is not required. Only when, in the presence of slit ventricles detected by CT/MRI examination, patients begin to suffer from an intense headache that interferes with normal life, and the diagnosis of "slit ventricular syndrome" is valid, requiring observation and treatment [36,37].…”

Section: The Syndrome Of Slit Ventricles Of the Brainmentioning

confidence: 99%

“…Rekate H. suggests limiting the use of the term "slit ventricular syndrome" to cases characterized by a triad of signs: intermittent headache lasting 10-30 minutes, smaller than the normal size of the brain ventricles according to neuroimaging, slow filling of the pump reservoir after its mechanical pressure [37].…”

Section: The Syndrome Of Slit Ventricles Of the Brainmentioning

confidence: 99%

“…Headaches, hypodynamia, and general cerebral symptoms in these patients may be caused by both transient ICH and hypotension, and the relative significance of these mechanisms in each case seems difficult to determine. To accurately verify the diagnosis of slit ventricular syndrome, a comprehensive examination is required, including monitoring of intracranial pressure, which will help to exclude other causes of cephalgia, for example, cases of "childhood migraine", that is, not requiring surgical manipulations [37].…”

Section: The Syndrome Of Slit Ventricles Of the Brainmentioning

confidence: 99%

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CSF Bypass Surgery in Children with Hydrocephalus: Modern Possibilities, Prospects and Ways of Solving the Correction of Complications

Samochernykh¹,

Zabrodskaya²,

Nikolaenko³

et al. 2023

Frontiers in Hydrocephalus

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The chapter discusses modern and promising approaches to the use of CSF shunting operations in children. CSF shunting operations remain the only effective method for correcting persistent CSF circulation disorders in CSF resorption disorders with the development of intracranial hypertension and hydrocephalus. The chapter is devoted to general ideas about CSF dynamics and biomechanical properties of the craniospinal system that affect CSF dynamics, and gives a pathogenetic assessment of CSF dynamics in the development of intracranial hypertension and hydrocephalus. Aspects of genetics and genomics of anomalies in hydrocephalus are touched upon. Pathological changes in the brain around old ventricular shunts are described. The authors consider the types of CSF shunting operations for hydrocephalus in children. Possible complications of CSF shunting operations are analyzed with the algorithm for their correction and management tactics for this group of patients.

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“…Animal FA model has also been proposed to study acute hydrocephalus and Human Immunodeficiency Virus (HIV) infection. The findings suggest that FA abnormalities were strong correlated with associated diseases, which represents a significant implication for the diagnostics and management neuro-deficit patients [16][17]. The study aimed to investigate the FA in various regions of rabbit brain during the development process using MR DTI at 3 T. The study was approved by an Institutional Animal Care and Use Committee of I-Shou University under protocol number IACUC-ISU-101032.…”

Section: Introductionmentioning

confidence: 99%

Monitoring fractional anisotropy in developing rabbit brain using MR diffusion tensor imaging at 3T

et al. 2016

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The aim of this study was to investigate the factional anisotropy (FA) in various regions of developing rabbit brain using magnetic resonance diffusion tensor imaging (MR DTI) at 3 T. A whole-body clinical MR imaging (MRI) scanner with a 15-channel high resolution knee coil was used. An echo-planar-imaging (EPI)-DTI pulse sequence was performed. Five 5 week-old New Zealand white (NZW) rabbits underwent MRI once per week for 24 weeks. After scanning, FA maps were obtained. ROIs (regions of interests) in the frontal lobe, parietal & temporal lobe, and occipital lobe were measured. FA changes with time were evaluated with a linear regression analysis. The results show that the FA values in all lobes of the brain increased linearly with age. The ranking of FA values was FA(frontal lobe) > FA(parietal & temporal lobe) > FA(occipital lobe). There was significant difference (p < 0.05) among these lobes. FA values are associated with the nerve development and brain functions. The FA change rate could be a biomarker to monitor the brain development. Understanding the FA values of various lobes during development could provide helpful information to diagnosis the abnormal syndrome earlier and have a better treatment and prognosis. This study established a brain MR-DTI protocol for rabbits to investigate the brain anatomy during development using clinical MRI. This technique can be further applied to the pre-clinical diagnosis, treatment, prognosis and follow-up of brain lesions.

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Changes of fractional anisotropy (FA) and apparent diffusion coefficient (ADC) in the model of experimental acute hydrocephalus in rabbits

Abstract: The study demonstrated the correlation of the neuroradiological parameters with morphological changes. The abnormality of the FA and ADC parameters in the obstructive hydrocephalus represents a significant implication for the diagnostics and management of hydrocephalus in patients.

Cited by 6 publications

References 42 publications

The role of perfusion and diffusion MRI in the assessment of patients affected by probable idiopathic normal pressure hydrocephalus. A cohort-prospective preliminary study

The role of perfusion and diffusion MRI in the assessment of patients affected by probable idiopathic normal pressure hydrocephalus. A cohort-prospective preliminary study

CSF Bypass Surgery in Children with Hydrocephalus: Modern Possibilities, Prospects and Ways of Solving the Correction of Complications

Monitoring fractional anisotropy in developing rabbit brain using MR diffusion tensor imaging at 3T

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