Changes of Intracranial Pressure in a Rat Meningitis Model

Pfister, Hans‐Walter; Dirnagl, Ulrich; Haberl, R.; Anneser, Franziska; Ködel, Uwe; Mehraein, P.; Feiden, W.; Einhäupl, K. M.

doi:10.1007/978-3-642-73987-3_207

Cited by 2 publications

(1 citation statement)

References 6 publications

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“…Hydrocephalus is also a common complication of PCNSI, although reported incidence varies markedly across studies (11.6–60%). 5 6 7 8…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Ventriculoperitoneal Shunt for Postoperative Central Nervous System Infection Complicated with Hydrocephalus

Chen,

Wang,

Wang

et al. 2024

Asian J Neurosurg

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Objective Our aim was to assess the efficacy of ventriculoperitoneal shunt (VPS) for treating postoperative central nervous system infection (PCNSI) complicated with hydrocephalus and to identify factors associated with treatment failure. Methods We conducted a retrospective analysis of PCNSI patients with hydrocephalus treated by VPS at the Department of Neurosurgery, the First Affiliated Hospital, College of Medicine, Zhejiang University, between December 2012 and January 2020. Functional recovery was evaluated during follow-up using the Glasgow Outcome Scale. Results A total of 29 patients (21 males, 8 females) were enrolled in the study (mean age: 56.4 ± 12.0 years, range: 18.0–77.0 years). Seventeen patients were treated successfully by VPS (58.6%). Among the 11 patients with shunt complications (37.9%), 8 (27.6%) presented with fever, 3 (10.3%) with shunt infection, and 3 (10.3%) with shunt obstruction. Univariate analysis identified low Glasgow Coma Scale (GCS) score (3–8) at the time of VPS and post-treatment fever as predictive of shunt failure. Conclusion VPS was effective for treating PCNSI complicated with hydrocephalus. However, patients with low GCS score at the time of VPS or fever post-treatment were at greater risk of shunt failure and poor outcome.

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“…Hydrocephalus is also a common complication of PCNSI, although reported incidence varies markedly across studies (11.6–60%). 5 6 7 8…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Ventriculoperitoneal Shunt for Postoperative Central Nervous System Infection Complicated with Hydrocephalus

Chen,

Wang,

Wang

et al. 2024

Asian J Neurosurg

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Microvascular Changes during the Early Phase of Experimental Bacterial Meningitis

Pfister¹,

Koedel²,

Haberl³

et al. 1990

J Cereb Blood Flow Metab

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131

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Summary:We investigated the temporal profile of the changes in regional CBF (rCBF) and intracranial pressure (ICP) during the early phase of pneumococcal meningitis in the rat. rCBF, as measured by laser-Doppler flowmet ry, and ICP were continuously monitored during 6 h post infection (pj.). Brain edema formation was assessed by brain water content determinations. Meningitis was in duced by intracisternal injection of 75 IJ-l of 107 colony forming units/ml pneumococci (n = 7). In control animals (n = 6), saline was injected. There was no change in the rCBF or ICP of controls throughout the experiment. However, there was a dramatic increase in rCBF and ICP associated with brain edema formation in untreated men ingitis animals. rCBF increased to 135.3 ± 33.8% (mean ± SD) in the untreated animals at I h pj. and reached 211.1 ± 40.5% at 6 h pj. (p < 0.05 compared with con trols). ICP increased from 2.9 ± 1.4 to 10.4 ± 4.7 mm Hg at 6 hpj. (p < 0.05 compared with controls). Brain water content was significantly elevated (79.69 ± 0.24 com pared with 78.94 ± 0. 16% in the control group, p < 0.05).

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Changes of Intracranial Pressure in a Rat Meningitis Model

Cited by 2 publications

References 6 publications

Efficacy of Ventriculoperitoneal Shunt for Postoperative Central Nervous System Infection Complicated with Hydrocephalus

Efficacy of Ventriculoperitoneal Shunt for Postoperative Central Nervous System Infection Complicated with Hydrocephalus

Microvascular Changes during the Early Phase of Experimental Bacterial Meningitis

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