Changes of microcirculation in rats detected by laser Doppler flowmetry at physical load accompanied by the development of thrombotic readiness

Abstract

Introduction. A considerable physical load can lead to the damage of various organs and systems including the system of the microcirculatory bloodstream. Materials and methods. The experimental groups of animals were exposed to 4-hour and 8-hour physical load. The state of the microcirculatory bloodstream was examined by means of laser Doppler flowmetry. Results. 4-hour physical load did not cause any reduction of the microcirculation parameter in rats. 8-hour physical load led to a decrease of the microcirculation parameter and further reduction of flux parameter. Conclusions. Such changes of microcirculation parameters can be one of the symptoms of development of the state of thrombotic readiness and high risk of thrombosis in rats after 8-hour physical load.