Changes of minimal erythema dose after water and salt water baths

Gambichler, Thilo; Schröpl, F

doi:10.1111/j.1600-0781.1998.tb00022.x

Cited by 23 publications

(28 citation statements)

References 14 publications

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“…A substantial keratolytic effect due to high salinity is unlikely as we measured UV transmission immediately after soaks. Indeed, the aforementioned observations contrast with previous studies showing rather increased UVB-induced erythema reactions after tap water and low-concentration salt water immersions [10,13,14,15]. On the other hand, neither Schiener et al [7] nor Dawe et al [5] observed in their large clinical psoriasis trials an increase in erythemal response to UVB after salt water exposure of different concentrations.…”

Section: Discussioncontrasting

confidence: 54%

“…We have previously found a more or less marked decrease in the MED for all liquids studied (tap water; 5, 10 and 20% NaCl solutions). The strongest percentage decrease of the MED (38.6 and 51.4%, respectively) was observed after tap water and 10% NaCl soaks [13]. …”

Section: Discussionmentioning

confidence: 99%

“…Enhanced UV transmission and a decrease in optical reflection and scattering due to salt water baths possibly include the biophysical mechanisms of action that may result, first, in an increase in erythema response after bathing and, second, in an increase in the therapeutically effective UV gain that may lead to improved treatment outcomes, in particular in psoriasis [4,10,12,13,14,15]. There is no standardized treatment regimen for BPT to date.…”

Section: Introductionmentioning

confidence: 99%

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The Impact of Salt Water Soaks on Biophysical and Molecular Parameters in Psoriatic Epidermis Equivalents

et al. 2011

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Background/Aims: The exact mechanisms of action of balneophototherapy are incompletely understood. We aimed to investigate the effect of salt water soaks on ultraviolet (UV) transmission and the expression of molecular parameters of psoriasis. Methods: We studied UV transmission and the expression of antimicrobial peptides and skin-derived antileukoproteinase (SKALP/elafin) in psoriatic epidermis equivalents which were pretreated with tap water and differently concentrated salt water solutions. Moreover, we performed in vivo phototoxicity tests in healthy subjects. Results: Highly concentrated salt water soaks significantly increase UV transmission through psoriatic epidermis equivalents, in particular within the wavelength range of 305– 360 nm. In vivo tests revealed increased photosensitivity following highly concentrated salt water baths. A significant decrease in human β-defensin-2 (hBD-2) and SKALP/elafin is observed after highly concentrated NaCl soaks. Conclusion: An increase in UV transmission following highly concentrated salt water soaks likely causes enhanced UV gain within the viable epidermis. Moreover, our data indicate that salt water soaks seem to influence the protein profiles of hBD-2 and SKALP/elafin.

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Section: Discussioncontrasting

confidence: 54%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Impact of Salt Water Soaks on Biophysical and Molecular Parameters in Psoriatic Epidermis Equivalents

et al. 2011

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“…In addition, the water itself could remove psoriatic scale [36], which may be beneficial for skin absorption of phototherapy. Previous studies have shown that water bath markedly increased photosensitivity to UVB [37, 38]. …”

Section: Discussionmentioning

confidence: 99%

Add-On Effect of Chinese Herbal Medicine Bath to Phototherapy for Psoriasis Vulgaris: A Systematic Review

Zhang

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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Psoriasis vulgaris is the most common form of psoriasis. Phototherapy has been proven effective for psoriasis, but side effects have become a concern. Chinese herbal medicine (CHM) bath combined with phototherapy has been used in clinical settings, but the additional benefit requires evaluation. This review aims to evaluate the additional benefit and safety of adding CHM bath to phototherapy for psoriasis vulgaris. Cochrane library, PubMed, Embase, CNKI, and CQVIP were searched from their inceptions to 6 August 2012. Randomized controlled trials (RCTs) comparing CHM bath plus phototherapy to phototherapy alone for psoriasis vulgaris were included. Data was analyzed using Review Manager 5.1.0. Thirteen RCTs were included in the review, and eight were included in the meta-analysis. Meta-analysis showed higher efficacy of CHM bath plus phototherapy when compared with phototherapy alone in terms of PASI 60 (RR 1.25; 95% CI: 1.18–1.32). Mild adverse events were reported in ten studies, but these could be alleviated by reducing UV dosage or applying emollient. In conclusion, CHM bath appears to be a beneficial and safe adjunctive therapy to phototherapy for psoriasis vulgaris. However, these results should be interpreted with caution due to the low methodological quality of the included studies.

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“…It has been shown that the photosensitivity to UV-B is markedly increased (lower MED) after exposure to tap-water or saltwater baths, but no concentration-dependent effect was found. 38 Other authors found a decrease in MED after baths in tap water or lowconcentration sodium chloride solution (Ͻ4%), but no decrease in MED after a bath in 26% sodium chloride solution. 15 In our study, both MED and cumulative UV doses did not differ between UV-B, TW UV-B, and SW UV-B.…”

Section: -02mentioning

confidence: 97%

Bath PUVA and Saltwater Baths Followed by UV-B Phototherapy as Treatments for Psoriasis

Schiener¹,

Brockow²,

Franke³

et al. 2007

Arch Dermatol

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To evaluate the efficacy of psoralens dissolved in a warm-water bath followed by exposure to UV-A irradiation (bath PUVA) or saltwater phototherapy (SW UV-B) compared with tap-water phototherapy (TW UV-B) or UV-B irradiation alone in psoriasis.Design: Multisite, prospective, randomized, controlled trial with 4 parallel groups.Setting: Total of 102 dermatologic outpatient clinics.Patients: Total of 1241 patients with stable psoriasis vulgaris and a Psoriasis Area and Severity Index score of 7 or greater.Interventions: Four-times-weekly UV-B, TW UV-B, SW UV-B, or bath-PUVA with baths preceding UV irradiation over a maximum of 8 weeks. The UV dose was adapted to erythemal response.Main Outcome Measures: Incidence of therapeutic success, defined as a reduction of the Psoriasis Area and Severity Index or affected body surface area of 50% or more.Results: Patients who received TW UV-B had a significantly higher incidence of therapeutic success than did patients treated with UV-B alone (60.7% vs 43.3%; PϽ.001; number needed to treat, 5.8; 95% confidence interval [CI], 3.9-10.9). Patients who received SW UV-B or bath PUVA had a significantly higher incidence of therapeutic success than did patients treated with TW UV-B (74.9% vs 60.7%; PϽ.001; number needed to treat, 7.0; 95% CI, 4.6-14.9; and 78.4% vs 60.7%; PϽ.001; number needed to treat, 5.7; 95% CI, 4.0-9.7, respectively). Bath PUVA was not superior to SW UV-B (78.4% vs 74.9%; P=.34). Conclusion:Bath PUVA and SW UV-B are comparably effective treatments in psoriasis and superior to UV-B and TW UV-B.

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Changes of minimal erythema dose after water and salt water baths

Cited by 23 publications

References 14 publications

The Impact of Salt Water Soaks on Biophysical and Molecular Parameters in Psoriatic Epidermis Equivalents

The Impact of Salt Water Soaks on Biophysical and Molecular Parameters in Psoriatic Epidermis Equivalents

Add-On Effect of Chinese Herbal Medicine Bath to Phototherapy for Psoriasis Vulgaris: A Systematic Review

Bath PUVA and Saltwater Baths Followed by UV-B Phototherapy as Treatments for Psoriasis

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