Changes of nerve excitability and urinary deltamethrin in sprayers

Abstract

The nerve excitability of median nerve as well as the urinary deltamethrin and its metabolite dibromovinyl-dimethyl-cyclopropane carboxylic acid (Br2A) were detected in 24 deltamethrin sprayers in an assessment of the exposure and effect of deltamethrin. Twenty-nine male, unexposed referents of the same age range were also selected. The urinary deltamethrin and its metabolite Br2A were detectable by GC and HPLC in the sprayers after exposure. The nerve excitability detected with an electromyograph and pairs of stimuli at variable intervals showed that there was a prolongation of supernormal period in median nerve of the exposed group after a 3-d spraying compared with that before spraying which became more significant 2 d after cessation of exposure. In the mean time, no change of supernormal period in the median nerve of reference group was found at the 3-d interval. Nearly half of the sprayers had a supernormal period prolonged by more than 4 ms after spraying, whereas nearly none of the reference group showed similar changes after repeated examinations. Although there was neither correlation between the nerve excitability changes and the urinary deltamethrin or Br2A excretion, nor was a case of acute deltamethrin poisoning diagnosed, the non invasive technique used for nerve excitability detection in this study seems to be valuable in studying deltamethrin toxicity on human.

Metabolites of Pyrethroid Insecticides in Urine Specimens: Current Exposure in an Urban Population in Germany

“…In several later studies with field workers and greenhouse workers exposed to permethrin and cypermethrin, the urinary metabolite Cl 2 CA was analyzed (1,11,12). Br 2 CA was found in the urine of workers exposed to deltamethrin by inhalation and dermal contact (13)(14)(15)(16). In 2 of 10 greenhouse workers exposed to deltamethrin, 3-PBA was detected, with a range of < 2-52 µg/L (17).…”

Environmental Health Assessment of Deltamethrin in a Malarious Area of Mexico: Environmental Persistence, Toxicokinetics, and Genotoxicity in Exposed Children

“…In this regard, it is important to take into account that, on the basis of human biomonitoring data, it has been difficult to relate exposure with effects. For example, dermal or neurologic symptoms in sprayers exposed to deltamethrin have showed no significant correlation with urinary metabolites excretion (He et al 1991; Zhang et al 1991). …”

Dissipation Behavior of 14C-Deltamethrin in Egyptian Soil Columns in Absence and Presence of Chlorpyrifos under Subtropical Conditions

“…This insecticide is considered to be useful insecticide due to its high insecticidal activity with low mammalian toxicity and limited soil persistence [16][17][18]. Most investigations done efforts focused on the photochemistry and metabolism of deltamethrin in plants and animals.…”