Changes of orexin A plasma levels in girls with anorexia nervosa during eight weeks of realimentation

Abstract

OXA levels in untreated AN patients differ significantly from healthy subjects and decrease during realimentation. These findings indicate that OXA may be involved in the nutritional regulation of malnourished children and adolescents.

Orexigenic and Anorexigenic Peptides in Restrictive Type of Anorexia Nervosa

“…We confirmed the results of other studies on the specific pattern of leptin in AN patients, such as baseline low levels and increase during treatment. We also corroborated an effect described by Bronsky et al (2010), such as a decrease of orexin A levels during anorexia treatment .…”

“…In the course of treatment and with subsequent weight gain, orexin A levels showed a further decline. A reduction of orexin A levels during AN realimentation was also found in a recent study of Bronsky et al (2010). However, their results differ with those of ours in that their baseline orexin A levels were higher than in healthy control participants.…”

“…However, in AN-R patients studied by us, such an association was observed only initially and has not hold during the course of treatment . Also Bronsky et al(2010) did not find such an association during an 8-week realimentation of AN patients. A limitation to our study may be that the participants in the control group had a narrower age range, which did not exactly match the AN-R patients for age.…”

Role of orexin receptor subtypes in the inhibitory effects of orexin-A on potassium chloride-induced increases in intracellular calcium ion levels in neurons derived from dorsal root ganglion of carrageenan-treated rats

“…Orexin-A has been shown to play a stimulatory role in feeding regulation (5) and could be involved in eating disorders such as anorexia nervosa (6). Orexin-A is also known to regulate energy homeostasis (7).…”

Orexin-A Activates Hypothalamic AMP-Activated Protein Kinase Signaling through a Ca2+-Dependent Mechanism Involving Voltage-Gated L-Type Calcium Channel

“…Orexin-A, a neuropeptide with a stimulatory effect on feeding via the selective orexin receptor-1 receptor (OX1R) (Sakurai et al, 1998;Edwards et al, 1999;Haynes et al, 2000;Yamada et al, 2000), is mainly secreted by the neurons in the lateral hypothalamic area that project far and wide in the hypothalamus, including the arcuate nucleus (ARC) (de Lecea et al, 1998;Date et al, 1999). It is well documented that orexin-A plays an important role in both normal energy homeostasis and abnormal control of eating behavior such as anorexia nervosa (Baranowska et al, 2008;Bronsky et al, 2011). NPY-containing neurons in the ARC, which have a strong orexigenic effect on feeding, have been shown to express orexin receptors, and much evidence supports that NPYergic signaling mediates orexin-A's appetite-stimulating effect (Dube et al, 2000;Ida et al, 2000;Jain et al, 2000;Yamanaka et al, 2000).…”