Changes of platelets’ function in preeclampsia

Babić, Goran; Novokmet, Slobodan; Janković, Slobodan

doi:10.2478/s11536-011-0076-3

Cited by 2 publications

(2 citation statements)

References 29 publications

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“…Therefore, platelets are ‘primed’ by various gestational adaptions to respond to stimulus. However, overactivation of platelets can stimulate damaging inflammatory pathways linked with venous thromboembolism and vascular disease, and has been linked to obstetric conditions such as PE and GDM [ 107 , 108 ].…”

Section: Immunological Regulation In Healthy Pregnancy and Its Dysregulation In Gdmmentioning

confidence: 99%

Gestational Diabetes Mellitus and Maternal Immune Dysregulation: What We Know So Far

McElwain

McCarthy

2021

IJMS

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Gestational diabetes mellitus (GDM) is an obstetric complication that affects approximately 5–10% of all pregnancies worldwide. GDM is defined as any degree of glucose intolerance with onset or first recognition during pregnancy, and is characterized by exaggerated insulin resistance, a condition which is already pronounced in healthy pregnancies. Maternal hyperglycaemia ensues, instigating a ‘glucose stress’ response and concurrent systemic inflammation. Previous findings have proposed that both placental and visceral adipose tissue play a part in instigating and mediating this low-grade inflammatory response which involves altered infiltration, differentiation and activation of maternal innate and adaptive immune cells. The resulting maternal immune dysregulation is responsible for exacerbation of the condition and a further reduction in maternal insulin sensitivity. GDM pathology results in maternal and foetal adverse outcomes such as increased susceptibility to diabetes mellitus development and foetal neurological conditions. A clearer understanding of how these pathways originate and evolve will improve therapeutic targeting. In this review, we will explore the existing findings describing maternal immunological adaption in GDM in an attempt to highlight our current understanding of GDM-mediated immune dysregulation and identify areas where further research is required.

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Section: Immunological Regulation In Healthy Pregnancy and Its Dysregulation In Gdmmentioning

confidence: 99%

Gestational Diabetes Mellitus and Maternal Immune Dysregulation: What We Know So Far

McElwain

McCarthy

2021

IJMS

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“…To our knowledge, this is the first study which reports the decrease in platelet mitochondrial function using the HRR method in preeclamptic vs. healthy pregnancies. A non-significant decrease in platelet count was found in both groups of healthy (non-PE) and preeclamptic (PE) pregnancies, which may be related to a lower platelet count (PC) in peripheral blood [ 32 , 33 ] or an increased platelet activation [ 34 ]; accordingly, PC did not influence the HRR experiments. An age-related difference in platelet respiratory rates has been reported in the literature, with a slightly increased ROUTINE respiration and decreased ET CII with the age, but without influencing the overall respiratory function [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Impairment of mitochondrial respiration in platelets and placentas: a pilot study in preeclamptic pregnancies

et al. 2022

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Preeclampsia (PE) is a major complication of pregnancy with partially elucidated pathophysiology. Placental mitochondrial dysfunction has been increasingly studied as major pathomechanism in both early- and late-onset PE. Impairment of mitochondrial respiration in platelets has recently emerged as a peripheral biomarker that may mirror organ mitochondrial dysfunction in several acute and chronic pathologies. The present study was purported to assess mitochondrial respiratory dys/function in both platelets and placental mitochondria in PE pregnancies. To this aim, a high-resolution respirometry SUIT (Substrate-Uncoupler-Inhibitor-Titration) protocol was adapted to assess complex I (glutamate + malate)- and complex II (succinate)-supported respiration. A decrease in all respiratory parameters (basal, coupled, and maximal uncoupled respiration) in peripheral platelets was found in preeclamptic as compared to healthy pregnancies. At variance, placental mitochondria showed a dichotomous behavior in preeclampsia in relation to the fetal birth weight. PE pregnancies with fetal growth restriction were associated with decreased in coupled respiration (oxidative phosphorylation/OXPHOS capacity) and maximal uncoupled respiration (electron transfer/ET capacity). At variance, these respiratory parameters were increased for both complex I- and II-supported respiration in PE pregnancies with normal weight fetuses. Large randomized controlled clinical studies are needed in order to advance our understanding of mitochondrial adaptive vs. pathological changes in preeclampsia.

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Changes of platelets’ function in preeclampsia

Cited by 2 publications

References 29 publications

Gestational Diabetes Mellitus and Maternal Immune Dysregulation: What We Know So Far

Gestational Diabetes Mellitus and Maternal Immune Dysregulation: What We Know So Far

Impairment of mitochondrial respiration in platelets and placentas: a pilot study in preeclamptic pregnancies

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