Changes of Renal Morphology and Function in Rats with Muscle Injury after Induced Skeletal Exercise

Abstract

Chronic kidney disease is a progressive disease characterized by chronic renal failure, which can lead to end-stage renal disease over time. Lipid metabolism disorder is a common disease in patients with chronic kidney disease. Lipid can directly or indirectly enhance the progress of renal damage through direct renal cytotoxicity or promoting renal arteriosclerosis. Therefore, it is of great significance to explore the research progress of renal morphology and function in rats with muscle injury induced by skeletal exercise. The purpose of this study is to explore the degree of renal injury and the changes of renal morphology and function after bone exercise, and to find out the relationship between them. In this study, four groups of experimental subjects were set up, which were blank control group, 12-hour exercise group, 24-hour exercise group and 48-hour exercise group. The results showed that the serum uric acid value of the rats after 48 hours of exercise was the highest, reaching 348.1 umol / L, while the serum creatinine index of the blank control group was the highest, which was 112.4 umol / L, which decreased with the increase of exercise time. The highest value of serum urea nitrogen in the blank control group was 5.53 mmol / L. The weight of rats decreased with the increase of exercise time, and the weight loss of rats after 48 hours of exercise was 6.1g. In the quantitative measurement of urinary protein, we can draw such a conclusion that the longer the exercise time, the higher the content of urinary protein, and with the passage of time, the content of urinary protein will return to the normal range, and the measurement results of red blood cell number also increase with the increase of exercise time. Changes of Renal Morphology and Motor FunctionInternational Journal of Sports Technology 34 Acute Kidney InjuryAcutekidneyinjury (Ard) is a syndrome that causes rapid decline in renal function due to various clinical manifestations. It may include multiple organs and systems. Incidence rate is 4%-20% in hospital patients, while in ICU, the morbidity rate in ICU is 30%, and the mortality rate is over 50%. This phenomenon caused by acute kidney injury has become a global medical and social problem. Investigation shows that about 30% of complex acute kidney damage has potential kidney disease, 25.6% secondary to baseline, 34.3% after major surgery, 47.5% with complications after septic shock, 26.9% with cardiac shock and 19% with drug-induced renal damage [4]. Compared with acute renal failure, the complex acute renal damage highlights the importance of early diagnosis and timely treatment of the syndrome. In recent years, it has been widely used and recognized by the medical community.Acute renal damage includes prenatal nitrite, idiopathic acute renal failure and acute tubular necrosis. Aki was described as early as ancient Greece, but there was no index of modern medicine at that time, and the diagnosis was only based on "reduced urine volume". With the development of pathology and biochemistry, mode...