Changes of Resistance to Activated Protein C in The Course of Pregnancy and Prevalence of Factor V Mutation

Mimuro, Shigeko; Lahoud, Robert; Beutler, Lucinda; Trudinger, Brian J.

doi:10.1111/j.1479-828x.1998.tb03002.x

Cited by 33 publications

(7 citation statements)

References 17 publications

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“…The overall prevalence of Factor V Leiden in Caucasians is cited as approximately 5%–6% but there is considerable racial and geographic variation 2,20 . Two previous Australian studies have reported prevalence rates of 0.07% 21 and 3.6% 22 for the Factor V Leiden, both figures considerably lower than that found in the present study. Heterogeneity of the Factor V Leiden within populations is evident in studies from the Netherlands 4,23 , Germany 9,24 and the UK 19 .…”

Section: Risk Of Bias In the Selection Of Normal Pregnancy Controlscontrasting

confidence: 80%

Is there an increased maternal–infant prevalence of Factor V Leiden in association with severe pre‐eclampsia?

Currie

Peek

McNiven

et al. 2002

BJOG

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Objective To compare the prevalence of the Factor V Leiden mutation in children and maternal–infant pairs in pregnancies affected by severe pre‐eclampsia with unmatched normal controls. Design Prospective cohort study. Setting Department of Women's and Children's Health, The Canberra Hospital, Garran, ACT, Australia. Sample Forty‐eight maternal–infant pairs where the index pregnancy was affected by severe pre‐eclampsia; 46 unmatched maternal–infant pairs where the index pregnancy was defined as normal. Methods DNA analysis of cheek swab samples obtained from maternal–infant pairs for the Factor V Leiden mutation. Main outcome measure The prevalence of the Factor V Leiden mutation in mothers, infants and maternal–infant pairs in association with severe pre‐eclampsia compared with unmatched controls. Results No difference was detected in the prevalence of Factor V Leiden mutation between the women and children of both groups, nor the maternal–infant pairs from each group. Conclusions No evidence was found of an increased prevalence of the Factor V Leiden mutation in either the mothers or children in association with severe pre‐eclampsia. This result argues against a Factor V Leiden fetal or maternal contribution to the development of severe pre‐eclampsia.

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Section: Risk Of Bias In the Selection Of Normal Pregnancy Controlscontrasting

confidence: 80%

Is there an increased maternal–infant prevalence of Factor V Leiden in association with severe pre‐eclampsia?

Currie

Peek

McNiven

et al. 2002

BJOG

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“…Table 2 summarizes the analysis of 23 studies involving 3131 patients and 4036 controls that assessed the association between FVL and all preeclampsia [7]–[10], [19]–[21], [23], [26], [27], [29], [30], [32], [33], [35], [41], [42], [44]–[47], [50], [51]. Meta-analysis revealed a significant association between FVL and preeclampsia (pooled OR = 1.60, 95% CI 1.28–2.00, p = 0.251, I 2 = 15.5%) when a fixed model was applied (Figure 6).…”

Section: Resultsmentioning

confidence: 99%

“…Severe preeclampsia was determined if one or more of the following features were present: blood pressure ≥160/110 mmHg; proteinuria >3+; oliguria; seizures; visual disturbances; headache; HELLP (hemolysis, elevated liver enzymes, and low platelets); right upper-quadrant pain; and thrombocytopenia. The remaining studies [7], [8], [32]–[52] used modified but relatively compatible diagnostic criteria.…”

Section: Methodsmentioning

confidence: 99%

“…From then on these two genetic polymorphisms were inferred to be associated with PE and many studies have been conducted to explore the relationship between them. Several studies suggested that FVL [7]–[9] and PT 20210 polymorphism [9], [10] were associated with an increased risk of preeclampsia. However, other studies showed inconsistent results.…”

Section: Introductionmentioning

confidence: 99%

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Association between Thrombophilia Gene Polymorphisms and Preeclampsia: A Meta-Analysis

et al. 2014

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ObjectiveTo estimate the relationship between the risk of preeclampsia and two thrombophilia gene single-nucleotide polymorphisms (SNPs), the factor V G1691A SNP and the prothrombin G20210A SNP.Date SourcesA systematic search of the English-language literature up to November 2012 was performed using Medline and EMBASE. Search terms included “preeclampsia,” “thrombophilia,” “factor V Leiden,” “prothrombin gene 20210,” and their combinations.Result(s)Thirty-seven studies with 5048 preeclampsia patients and 6796 controls were included in the meta-analysis. We found that the prothrombin G20210A polymorphism was associated with an increased risk of all preeclampsia (pooled odds ratio (OR) = 1.81, 95% confidence interval (CI) 1.25–2.63) and severe preeclampsia (pooled OR = 3.02, 95%CI 2.06–4.45). Meanwhile, the pooled OR for the association between factor V Leiden and all preeclampsia was 1.60 (95%CI 1.28–2.00) and 2.45 (95%CI 1.63–3.69) for the cases of severe preeclampsia.Conclusion(s)This meta-analysis supports that the factor V G1691A SNP and the prothrombin G20210A SNP are associated with an increased risk for both preeclampsia overall and severe preeclampsia.

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“…As shown in Figure , 477 articles were filtered after reviewing based on the exclusion criteria, including the title or abstract relevance to our study, is it possible to get full‐text, and does it exist detailed data. Finally, a total of 50 case–control studies(Table ) involving 6041 cases and 8364 controls were ultimately included in our meta‐analysis. All data were obtained from existing studies, with populations from Europe, the Middle East, North America, Latin America, Asia or Australia.…”

Section: Resultsmentioning

confidence: 99%

Association of hypertensive disorders of pregnancy risk and factor V Leiden mutation: A meta‐analysis

Ruan

2019

J of Obstet and Gynaecol

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Aim To date, the conclusions of studies on a possible association between factor V Leiden (FVL, FV G1691A, rs6025) and hypertensive disorders of pregnancy (HDP) are conflicting. Here, we aimed to estimate the relationship between the risk of HDP and FVL. Methods Eligible studies focused on FVL and HDP were searched from the PubMed and the Web of Science databases up to March 31, 2018. We used random effects model for the meta‐analysis, and I2 statistic to assess the degree of heterogeneity between all included studies. To evaluate the association between FVL and the risk of HDP, we calculated the odds ratio (OR) and 95% confidence intervals (CI) comparing cases and controls of all samples and each subgroup based on different regions. Results Fifty citations on FVL and HDP were identified through the literature search, and a meta‐analysis on the GA + AA genotype between 6041 cases and 8364 controls was conducted. The holistic analysis found that pregnant women with GA or AA genotype of FVL have a 1.97‐fold (95% CI: 1.64–2.35, P < 0.00001) increased risk of HDP compared with GG carriers. While the OR are 2.23 (95% CI: 1.76–2.84, P < 0.00001) and 1.90 (95% CI: 1.12–3.23, P = 0.02) in Europe and the Middle East subgroups, respectively. Conclusion Factor V Leiden mutation is associated with an increased risk of HDP, and is particularly associated with preeclampsia and eclampsia in European women. However, further high‐quality studies are warranted to confirm the possible effectiveness of FVL in HDP patients.

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Changes of Resistance to Activated Protein C in The Course of Pregnancy and Prevalence of Factor V Mutation

Cited by 33 publications

References 17 publications

Is there an increased maternal–infant prevalence of Factor V Leiden in association with severe pre‐eclampsia?

Is there an increased maternal–infant prevalence of Factor V Leiden in association with severe pre‐eclampsia?

Association between Thrombophilia Gene Polymorphisms and Preeclampsia: A Meta-Analysis

Association of hypertensive disorders of pregnancy risk and factor V Leiden mutation: A meta‐analysis

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