Changes of Schizophrenia Spectrum Disorder in DSM-5: Dispute between Categorical and Dimensional Approaches

Guo, Yafei; Jin, Shenghua; Wang, Jianping; Lin-hua, WU; Aidi, Ma

doi:10.3724/sp.j.1042.2015.01428

Cited by 1 publication

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“…Patients diagnosed with elderly schizophrenia in the First Hospital of Hebei Medical University were recruited from January 2020 to December 2021. The inclusion criteria were as follows: (1) meeting the diagnostic criteria for schizophrenia in the Diagnostic and Statistical Manual of Mental Disorders Fifth Edition (DSM‐5) (Guo et al., 2015); (2) being without electric convulsions, not taking antipsychotic drugs or sedatives 2 weeks before enrollment, and dextromanuality; (3) no obvious organic lesions based on head CT or MRI; (4) age ranged from 60 to 86 years old; and (5) informed consent signed by family members of patients. The exclusion criteria were as follows: (1) loss of consciousness caused by traumatic brain injury for more than 30 min, (2) a history of alcohol and neuroactive substance abuse, (3) mental retardation, (4) mental disorders caused by physical or cerebrovascular diseases, (5) liver and kidney dysfunction, (6) being with severe hearing impairment, and (7) being unwilling to participate in the study of patient's family.…”

Section: Methodsmentioning

confidence: 99%

Study on clinical characteristics of event‐related potential P300 in elderly schizophrenics and associated risk factors

Zhou

et al. 2023

Brain and Behavior

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Objective To investigate the clinical characteristics of event‐related potential P300 in elderly schizophrenics with different levels of violence and the risk factors of severe violence. Methods A total of 138 elderly schizophrenic patients from January 2020 to December 2021 in the First Hospital of Hebei Medical University were enrolled in this retrospective analysis. Based on the violence risk assessment, 61, 102, and 145 patients were divided into high‐risk, medium‐risk, and low‐risk groups, respectively. Clinical characteristics, P300 latency, and P300 amplitude were compared among the three groups followed by a logistic regression analysis of elderly schizophrenics with severe violence. Results The latency of P300 in the high‐risk group was higher than that in the low‐risk group (p < .05). The P300 amplitude of patients in the high‐risk group was significantly lower than that in the low‐risk group (p < .05). Univariate logistic regression analysis showed that previous history of violence, delusion of persecution, P300 latency, and amplitude were independent influencing factors of severe violence in elderly schizophrenics (odds ratio [OR]: 0.022, 95% confidence interval [CI]: 0.007–0.067, p < .001; OR: 0.118, 95% CI: 0.043–1.763, p = .037; OR: 1.289, 95% CI: 1.142–1.673, p < .001; and OR: 0.049, 95% CI: 0.021–0.067, p < 0.001, respectively). After adjusting gender, age, and other confounding factors, multivariate logistic regression analysis showed that delusion of persecution, P300 latency, and P300 amplitude were associated with severe violence in elderly schizophrenics (OR: 2.211, 95% CI: 0.061–4.067, p < .001; OR: 2.006, 95% CI: 1.421–2.721, p = .017; and OR: 0.067, 95% CI: 0.037–0.276; p < .001; respectively). Conclusion The latency and amplitude of P300 can be used as effective neuroelectrophysiological indicators to evaluate the violence level of elderly schizophrenics. Delusion of persecution, P300 latency, and P300 amplitude were independent influencing factors of severe violence in elderly schizophrenics.

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Section: Methodsmentioning

confidence: 99%