Changes of serum adipocytokines and body weight following Zingiber officinale supplementation in obese women: a RCT

Attari, Vahideh Ebrahimzadeh; Ostadrahimi, Alireza; Jafarabadi, Mohammad Asghari; Mehralizadeh, Sajjad; Mahluji, Sepideh

doi:10.1007/s00394-015-1027-6

Cited by 63 publications

(45 citation statements)

References 29 publications

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“…Furthermore, this is also in line with a recent study by Lopez et al [24] who demonstrated that a supplement containing caffeine and capsaicin for 8 weeks accentuated body weight and fat loss during a weight loss program. A significant decrease in BMI was also seen following the supplementation with 2 g/day of ginger powder among obese women for 12 weeks [10]. Green tea, capsaicin and ginger appear to complement each other by acting on the various pathways of the sympathetic nervous system at the cellular and molecular levels.…”

Section: Discussionmentioning

confidence: 99%

“…In another study, the consumption of a dietary supplement containing epigallocatechin gallate (EGCG), capsaicins, piperine and L-carnitine for 8 weeks among overweight subjects decreased insulin resistance and LDL-cholesterol levels [9]. A significant decrease in body mass index (BMI), serum insulin, insulin resistance and a significant increase in insulin sensitivity were also seen following the administration of 2 g/day of ginger powder among obese women for 12 weeks [10]. …”

Section: Introductionmentioning

confidence: 99%

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The Effect of Dietary Supplements Containing Green Tea, Capsaicin and Ginger Extracts on Weight Loss and Metabolic Profiles in Overweight Women: A Randomized Double-Blind Placebo-Controlled Clinical Trial

Taghizadeh

Farzin²,

Taheri³

et al. 2017

Ann Nutr Metab

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Background: This study was conducted to determine the effects of dietary supplements containing green tea, capsaicin and ginger extracts on weight loss and metabolic profiles among overweight women. Methods: This randomized double-blind placebo-controlled clinical trial was implemented among 50 overweight women. Participants were randomly divided into 2 groups. Group A received dietary supplements containing 125 mg green tea, 25 mg capsaicin and 50 mg ginger extracts (n = 25) group B received placebos (n = 25) twice with lunch and twice with dinner daily for 8 weeks. Results: Compared with placebo, taking dietary supplements containing green tea, capsaicin and ginger resulted in a significant decrease in weight (-1.8 ± 1.5 vs. +0.4 ± 1.2 kg, respectively, p < 0.001) and body mass index (BMI; -0.7 ± 0.5 vs. +0.1 ± 0.5 kg/m², respectively, p < 0.001). In addition, subjects who received green tea, capsaicin and ginger co-supplements had significantly decreased serum insulin concentrations (-2.6 ± 3.9 vs. -0.6 ± 2.0 µIU/mL, p = 0.02), homeostatic model of assessment for insulin resistance (-0.5 ± 0.8 vs. -0.05 ± 0.6, p = 0.01), and increased quantitative insulin sensitivity check index (+0.01 ± 0.01 vs. +0.001 ± 0.01, p = 0.008) and plasma glutathione (GSH) levels (+73.8 ± 120.6 vs. -28.3 ± 193.4 µmol/L, p = 0.03) compared with the placebo. Conclusions: Our study indicated that taking green tea, capsaicin and ginger co-supplements for 8 weeks among overweight women had beneficial effects on weight, BMI, markers of insulin metabolism and plasma GSH levels.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Effect of Dietary Supplements Containing Green Tea, Capsaicin and Ginger Extracts on Weight Loss and Metabolic Profiles in Overweight Women: A Randomized Double-Blind Placebo-Controlled Clinical Trial

Taghizadeh

Farzin²,

Taheri³

et al. 2017

Ann Nutr Metab

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“…For example, an early study showed that dietary intake of ginger could enhance thermogenesis and reduce feelings of hunger . Moreover, ginger supplementation showed a beneficial effect on weight loss and some obesity‐associated parameters in overweight and obese adults …”

Section: Preventive Effects Of Ginger On Metabolic Diseasesmentioning

confidence: 99%

Beneficial effects of ginger Zingiber officinale Roscoe on obesity and metabolic syndrome: a review

Jing

Bao

et al. 2017

Annals of the New York Academy of Sciences

136

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In recent years, metabolic syndromes (MetSs), including diabetes mellitus, dyslipidemia, and cardiovascular diseases, have become a common health problem in both developed and developing countries. Accumulating data have suggested that traditional herbs might be able to provide a wide range of remedies in prevention and treatment of MetSs. Ginger (Zingiber officinale Roscoe, Zingiberaceae) has been documented to ameliorate hyperlipidemia, hyperglycemia, oxidative stress, and inflammation. These beneficial effects are mediated by transcription factors, such as peroxisome proliferator-activated receptors, adenosine monophosphate-activated protein kinase, and nuclear factor κB. This review focuses on recent findings regarding the beneficial effects of ginger on obesity and related complications in MetS and discusses its potential mechanisms of action. This review provides guidance for further applications of ginger for personalized nutrition and medicine.

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“…For instance, digestive disorder, hypertension, inflammation, and cold are common diseases where ginger can be used [11]. The marker compounds contained in ginger, particularly gingerol and shogaol, have been reported exhibit important antioxidant properties with remarkable anticancer, and antimutagenic effect [12], analgesic [13], inhibit melanoma [11], inhibit platelet aggregation [14], antihyperlipidemia [15], antidiabetes [16], ameliorate renal and pancreas damage [17], and so on. Certain compounds contained in (Z. officinale) demonstrate synergistic effect as auxiliary chemical agent against on C. albicans, Enterococcus faecalis, Escherichia coli, and their endotoxins [18] and also other microbes [19].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Antifungal Activity of a 3-Extract Formulation in Topical Dosage Form and Its Safety Aspect

Sukandar

Safitri

Susanto

et al. 2016

Asian J Pharm Clin Res

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Objective: To determine the combination of extract of Rosmarinus officinalis leaves, Zingiber officinale rhizome, and Curcuma xanthorrhiza rhizome in 2 form topical preparations, cream, and ointment, through in situ study, as well as to evaluate safety aspect of both cream and ointment.Methods: Irritation skin and eye test were performed according to OECD guideline. Rabbits were also used as an object of the in situ study. A suspension of Trichophyton mentagrophytes was injected through the skin on both sides of rabbit's back to induce dermatophytosis. Throughout the treatment period, topical preparation was applied to the infected site until the wound was fully recovered.Results: There was no significant irritation effect on both topical dosage forms. However, an incidence of redness was observed in the skin applied by cream. Healing rate of extract in ointment. Conclusion:Combination of the corresponding extract showed antifungal activity and was comparable to that of ketoconazole as a reference drug.

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Changes of serum adipocytokines and body weight following Zingiber officinale supplementation in obese women: a RCT

Cited by 63 publications

References 29 publications

The Effect of Dietary Supplements Containing Green Tea, Capsaicin and Ginger Extracts on Weight Loss and Metabolic Profiles in Overweight Women: A Randomized Double-Blind Placebo-Controlled Clinical Trial

The Effect of Dietary Supplements Containing Green Tea, Capsaicin and Ginger Extracts on Weight Loss and Metabolic Profiles in Overweight Women: A Randomized Double-Blind Placebo-Controlled Clinical Trial

Beneficial effects of ginger Zingiber officinale Roscoe on obesity and metabolic syndrome: a review

Evaluation of Antifungal Activity of a 3-Extract Formulation in Topical Dosage Form and Its Safety Aspect

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