Changes of serum interleukin-6 in healthy pregnant women and establishment of relevant reference intervals

Fu, Yaoyang; Tang, Lingli; Hu, Min; Xiang, Zhongyuan; Hu, Yun

doi:10.1016/j.cca.2019.12.013

“…The salivary levels of 8-OHdG, IL-1 β , and IL-6 were measured in the present study and showed no significant differences between PTB and FTB in every group. Although 8-OHdG in saliva increased during pregnancy [ 25 ], serum IL-6 in the third trimester of pregnancy was higher than in the first trimester [ 26 ], which did not provide any information about the difference between PTB and FTB. In our previous study [ 19 ], IL-1 β in GCF did not change during pregnancy.…”

Section: Discussionmentioning

confidence: 99%

A Nested Case-Control Study of the Relationship between Salivary Inflammatory Mediators, Periodontal Parameters, and Preterm Birth in a Chinese Population

Wu

¹

,

Ye

²

,

Li

³

et al. 2022

BioMed Research International

1

0

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Background. To explore whether salivary inflammatory mediators and periodontal indices at different gestational stages can be taken as indicators of preterm birth (PTB). Methods. This nested case-control study enrolled systemically healthy pregnant women at 9 to 36 weeks of gestation. Periodontal indices were measured at the enrollment date, and interleukin-1β (IL-1β), IL-6, tumor necrosis factor (TNF-α), prostaglandin E2 (PGE2), and 8-hydroxy-deoxyguanosine (8-OHdG) in the saliva were determined by enzyme-linked immunosorbent assay (ELISA). The birth outcome was recorded. Results. PTB occurred in 26 women. A total of 104 matched women with full-term birth (FTB) were used as controls. The PTB women enrolled at 24-28 gestational weeks displayed a significantly greater bleeding index (BI), probing pocket depth (PD), PD ≥ 4 mm sites (%), saliva-TNF-α, and saliva-PGE2 ( P < 0.05 ). BI and PGE2 in the saliva were found to be positively associated with PTB ( OR = 4.79 , P = 0.048 , 95 % CI = 1.014 to 22.628 ; OR = 1.07 , P = 0.04 , 95 % CI = 1.004 to 1.135 , respectively). The areas under the receiver operating characteristic curve (ROC) of BI and saliva-PGE2 were 0.82 and 0.78, respectively, and that of the combined detection was 0.91, which was larger than either marker alone, although the differences were not significant ( P > 0.05 ). Conclusions. The combination of BI and PGE2 in saliva at 24-28 gestational weeks could be a predictor of PTB in asymptomatic women. However, the results should be further explored with larger sample size.

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“…Increased cytokine concentrations have been reported during spontaneous term labour [21,22]. Fu et al, [23] observed higher serum IL-6 concentration in pregnant women compared to non-pregnant women. Gillespie et al [24] documented increased IL-6 concentration in late pregnancy which reached peak levels during labour.…”

Section: Em = Mean Values ± Standard Error Of Meansmentioning

confidence: 98%

Evaluation of Serum Interleukin-6 and C-Reactive Protein Levels among Women During Term Labour

James

¹

,

Imaralu

²

,

Esiaba

³

2020

JAMMR

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Aims: To determine the serum concentrations of C-reactive protein (CRP) and interleukin 6 (IL-6) as well as level of leukocytosis, as inflammatory contributory factors in women with uncomplicated term pregnancies before, during and after labour. Study Design: This is a cross-sectional study. Place and Duration of Study: The study was carried out in the Department of Obstetrics and Gynaecology of Babcock University Teaching Hospital (BUTH) and Department of Biochemistry, Babcock University, Ogun State Nigeria between June 2019 and February 2020. Methodology: 45 venous blood samples were obtained from 34 selected women and grouped into three; prenatal (≥ 32 weeks, n = 18), labour (4 to 6 cm dilation, n = 12) and postnatal (≤ 24 hour postpartum, n = 15). Sixteen blood samples were also obtained from the umbilical cord. Levels of CRP and IL-6 were determined by Enzyme Linked Immunosorbent Assay (ELISA) techniques and the leukocyte count, by hematologic method. Differences in statistical mean were evaluated by one way analysis of variance (ANOVA) with Bonferroni post hoc comparison. The level of significance was set at P < 0.05. Results: Concentration of serum IL-6 was significantly high during labour (1354.79 ± 189.16 pg/mL) compared to the prenatal (14.94 ± 4.86 pg/mL, P < .001) and postnatal (13.17 ± 3.06 pg/mL, P < .001) periods. The low level of CRP observed during active labour compared to the prenatal and postnatal periods did not reach significant difference. The levels of these inflammatory markers were low in the cord blood. Leukocyte counts (P = .011) as well as neutrophils (P = .014) and MID cell fractions (P = .004) were significantly higher during the postnatal period. Conclusion: The high levels of serum IL-6 observed in this study supports human term labour as an inflammatory event not associated with increased leukocytosis.

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“…Measurements of the circulating cytokine levels show that IL-6 levels are generally found to be elevated in pregnant vs. non-pregnant women [ 67 ], especially in the second and third trimester [ 66 , 67 ]. Longitudinal assessments of IL-6 concentrations in the maternal circulation over the course of pregnancy, adjusted for maternal body mass index (BMI) and other confounders, yield rather conflicting findings ( Table 1 ).…”

Section: Il-6 and Il-8 In A Healthy Pregnancymentioning

confidence: 99%

“…Longitudinal assessments of IL-6 concentrations in the maternal circulation over the course of pregnancy, adjusted for maternal body mass index (BMI) and other confounders, yield rather conflicting findings ( Table 1 ). While several studies report a progressive increase of IL-6 with advancing gestational age [ 64 , 65 , 66 , 67 , 69 ], no significant differences between trimesters [ 68 , 70 , 71 , 72 ], or a decrease in the circulating IL-6 levels during gestation [ 73 , 74 ], have also been observed.…”

Section: Il-6 and Il-8 In A Healthy Pregnancymentioning

confidence: 99%

IL-6 and IL-8: An Overview of Their Roles in Healthy and Pathological Pregnancies

Vilotić

¹

,

Nacka-Aleksić

²

,

Pirković

³

et al. 2022

IJMS

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Interleukin-6 (IL-6) is an acknowledged inflammatory cytokine with a pleiotropic action, mediating innate and adaptive immunity and multiple physiological processes, including protective and regenerative ones. IL-8 is a pro-inflammatory CXC chemokine with a primary function in attracting and activating neutrophils, but also implicated in a variety of other cellular processes. These two ILs are abundantly expressed at the feto-maternal interface over the course of a pregnancy and have been shown to participate in numerous pregnancy-related events. In this review, we summarize the literature data regarding their role in healthy and pathological pregnancies. The general information related to IL-6 and IL-8 functions is followed by an overview of their overall expression in cycling endometrium and at the feto-maternal interface. Further, we provide an overview of their involvement in pregnancy establishment and parturition. Finally, the implication of IL-6 and IL-8 in pregnancy-associated pathological conditions, such as pregnancy loss, preeclampsia, gestational diabetes mellitus and infection/inflammation is discussed.

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Changes of serum interleukin-6 in healthy pregnant women and establishment of relevant reference intervals

Cited by 15 publications

References 12 publications

A Nested Case-Control Study of the Relationship between Salivary Inflammatory Mediators, Periodontal Parameters, and Preterm Birth in a Chinese Population

A Nested Case-Control Study of the Relationship between Salivary Inflammatory Mediators, Periodontal Parameters, and Preterm Birth in a Chinese Population

Evaluation of Serum Interleukin-6 and C-Reactive Protein Levels among Women During Term Labour

IL-6 and IL-8: An Overview of Their Roles in Healthy and Pathological Pregnancies

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