Changes of synaptic ultrastructure in the guinea pig interpositus nuclei associate with response magnitude and timing after trace eyeblink conditioning

Hu, Bo; Chen, Hao; Yang, Li; Tao, Zhong-fen; Yan, Jie; Zhu, Zhi-ru; Huang, Wei; Huang, Wenqi; Sui, Jian-feng

doi:10.1016/j.bbr.2011.10.011

Cited by 12 publications

(8 citation statements)

References 75 publications

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“…In contrast, unpaired presentations of the stimulation CS and airpuff US did not obtain CR across 10 d of training, suggesting that CRs observed in the conditioned groups were due to associative learning. Against our expectations, the guinea pigs acquired long TEC slower than both DEC and short TEC, in agreement with the previous studies using peripheral CS (eg, a tone or a light CS) in eyeblink conditioning [64,65] . There is a possibility that the longer trace interval between the CS and the US makes it difficult for them to timely converge inside brain, and that additional brain regions such as the hippocampus, mPFC and amygdala are required for establishment of long TEC [6, 13, 17, 18, 22-24, 53, 54, 66-69] .…”

Section: Discussionsupporting

confidence: 93%

Classical eyeblink conditioning using electrical stimulation of caudal mPFC as conditioned stimulus is dependent on cerebellar interpositus nucleus in guinea pigs

Yao

Fan

et al. 2012

Acta Pharmacol Sin

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Aim: To determine whether electrical stimulation of caudal medial prefrontal cortex (mPFC) as conditioned stimulus (CS) paired with airpuff unconditioned stimulus (US) was sufficient for establishing eyeblink conditioning in guinea pigs, and whether it was dependent on cerebellar interpositus nucleus. Methods: Thirty adult guinea pigs were divided into 3 conditioned groups, and trained on the delay eyeblink conditioning, short-trace eyeblink conditioning, and long-trace eyeblink conditioning paradigms, respectively, in which electrical stimulation of the right caudal mPFC was used as CS and paired with corneal airpuff US. A pseudo conditioned group of another 10 adult guinea pigs was given unpaired caudal mPFC electrical stimulation and the US. Muscimol (1 µg in 1 µL saline) and saline (1 µL) were infused into the cerebellar interpositus nucleus of the animals through the infusion cannula on d 11 and 12, respectively. Results: The 3 eyeblink conditioning paradigms have been successfully established in guinea pigs. The animals acquired the delay and short-trace conditioned responses more rapidly than long-trace conditioned responses. Muscimol infusion into the cerebellar interpositus nucleus markedly impaired the expression of the 3 eyeblink conditioned responses. Conclusion: Electrical stimulation of caudal mPFC is effective CS for establishing eyeblink conditioning in guinea pigs, and it is dependent on the cerebellar interpositus nucleus.

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Section: Discussionsupporting

confidence: 93%

Classical eyeblink conditioning using electrical stimulation of caudal mPFC as conditioned stimulus is dependent on cerebellar interpositus nucleus in guinea pigs

Yao

Fan

et al. 2012

Acta Pharmacol Sin

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“…As we previously reported [12,48], the 85-dB tone CSs evoked obvious SRs in all training days. Typically, these responses started [24.2 ± 3.4 ms, mean ± SD, Fig.…”

Section: Correlation Between Baseline Mpfc Theta Activity With Cr Extsupporting

confidence: 84%

“…As illustrated in Fig. 6A and B, theta power in both the Cg and the PrL remained to be relatively stable across the extinction (Cg: n = 8, [0.34 ± 0.14], mean ± SD; F [6,42] = 0.641, p = 0.697; PrL: n = 9, [0.38 ± 0.19], mean ± SD; F [6,48] = 0.133, p = 0.991; one-way ANOVA with repeated measures). However, significant association of baseline theta activity with CR extinction was noted in the Cg (n = 8; F [1,6] = 7.879, p = 0.026; Days × Trial types interactions: Fig.…”

Section: Correlation Between Baseline Mpfc Theta Activity With Cr Extmentioning

confidence: 94%

Baseline theta activities in medial prefrontal cortex and deep cerebellar nuclei are associated with the extinction of trace conditioned eyeblink responses in guinea pigs

Wang

Chen

et al. 2014

Behavioural Brain Research

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“…When right whisker vibration is repeatedly paired with an airpuff to the right cornea in trace eyeblink conditioning (tEBC), the left SI and right IPN are important for acquisition and memory retrieval (Woodruff-Pak et al 1985;Galvez et al 2007;Green and Arenos 2007;Plakke et al 2007;Pakaprot et al 2009;Hu et al 2010Hu et al , 2012Wu et al 2012). If either are lesioned prior to the start of training, the tEBC task will not be acquired.…”

Section: Discussionmentioning

confidence: 99%

“…The hippocampus (Solomon et al 1986;Moyer et al 1990;Kim et al 1995;Weiss et al 1999), medial prefrontal cortex (Kronforst-Collins and Disterhoft 1998;Weible et al 2000;McLaughlin et al 2002;Takehara et al 2003), and somatosensory cortex (Galvez et al 2007) are essential in whiskersignaled trace conditioning. In addition, the neural pathway of the CS, US, and conditioned blink all incorporate the cerebellar interpositus nucleus (IPN) (Woodruff-Pak et al 1985;Green and Arenos 2007;Plakke et al 2007;Pakaprot et al 2009;Hu et al 2010Hu et al , 2012Wu et al 2012) and it is in this region where information about the CS and US both converge (McCormick et al 1982;Clark et al 1984;Yeo et al 1985;Lavond and Steinmetz 1989;Krupa et al 1993Krupa et al , 1996Thompson 1995, 1997;Thompson 2003, 2005).…”

Section: [Supplemental Materials Is Available For This Article]mentioning

confidence: 99%

Pretrial functional connectivity differentiates behavioral outcomes during trace eyeblink conditioning in the rabbit

et al. 2016

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Fluctuations in neural activity can produce states that facilitate and accelerate task-related performance. Acquisition of trace eyeblink conditioning (tEBC) in the rabbit is enhanced when trials are contingent on optimal pretrial activity in the hippocampus. Other regions which are essential for whisker-signaled tEBC, such as the cerebellar interpositus nucleus (IPN), somatosensory and prelimbic cortices, may also show optimal connectivity prior to successful performance. Functional magnetic resonance imaging (fMRI) was acquired in nine rabbits during tEBC on the first and tenth days of initial training and once again after a 30-d, training-free hiatus. Data acquired during the intertrial interval was parsed depending on whether or not a conditioned response (CR) occurred on the upcoming trial and seed-based functional connectivity was calculated among the IPN, hippocampus, somatosensory, and prelimbic cortices. Functional connectivity between the left somatosensory cortex and right IPN, regions critical for establishing and producing CRs evoked by right vibrissae vibration and right corneal airpuff, was significantly negative prior to successful, CR trials as compared with unsuccessful, non-CR trials. Differences were not observed for any of the other possible combinations of connectivity. Our results demonstrate that specific pretrial functional connectivity exists within the rabbit brain and differentiates between upcoming behavioral response outcomes. Online analysis of network fluctuations has the potential to be used as the basis for therapeutic interventions to facilitate learning and memory.

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Changes of synaptic ultrastructure in the guinea pig interpositus nuclei associate with response magnitude and timing after trace eyeblink conditioning

Cited by 12 publications

References 75 publications

Classical eyeblink conditioning using electrical stimulation of caudal mPFC as conditioned stimulus is dependent on cerebellar interpositus nucleus in guinea pigs

Classical eyeblink conditioning using electrical stimulation of caudal mPFC as conditioned stimulus is dependent on cerebellar interpositus nucleus in guinea pigs

Baseline theta activities in medial prefrontal cortex and deep cerebellar nuclei are associated with the extinction of trace conditioned eyeblink responses in guinea pigs

Pretrial functional connectivity differentiates behavioral outcomes during trace eyeblink conditioning in the rabbit

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