2016
DOI: 10.1111/ggi.12772
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Changes of telomere status with aging: An update

Abstract: Accumulated data have shown that most human somatic cells or tissues show irreversible telomere shortening with age, and that there are strong associations between telomere attrition and aging-related diseases, including cancers, diabetes and cognitive disorders. Although it has been largely accepted that telomere attrition is one of the major causes of aging-related disorders, critical aspects of telomere biology remain unresolved, especially the lack of standardized methodology for quantification of telomere… Show more

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Cited by 41 publications
(28 citation statements)
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References 128 publications
(262 reference statements)
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“…Two types of induced senescence have commonly been used to study aging in vitro , including replicative senescence (RS) and stress-induced premature senescence (SIPS) [4749]. RS is characterized by progressive telomere shortening, which occurs at every cell division.…”
Section: Resultsmentioning
confidence: 99%
“…Two types of induced senescence have commonly been used to study aging in vitro , including replicative senescence (RS) and stress-induced premature senescence (SIPS) [4749]. RS is characterized by progressive telomere shortening, which occurs at every cell division.…”
Section: Resultsmentioning
confidence: 99%
“…Fitter telomeres would favor cancer development and protect from chemotherapy-derived toxicity; the role of telomere fitness in cancer cells and response to treatment reminds to be elucidated. Finally, besides age, several genetic and environmental factors influence telomere shortening; our control and study populations might have had different exposure to such factors what would account for the observed differences, but those data were not gathered in our study [37, 38]. All these scenarios should be carefully assessed in independent studies.…”
Section: Discussionmentioning
confidence: 97%
“…This enzyme is known to be essential for the synthesis of specialized ribonuclear proteins (the telomeres) that extend the ends of linear eukaryotic chromosomes. These molecular extensions are key for stabilizing chromosomal structure [26,27] and, as they shorten with each cell division as it occurs in normal cells [28,29], chromosomal structure is weakened leading to genetic instability and cellular aging. On the contrary, the usual upregulation of telomerase activity in cancer cells allows them to maintain DNA stability and contributes to their immortalization even though they undergo frequent mitoses.…”
Section: Introductionmentioning
confidence: 99%