Changes of the release of luteinizing hormone (LH) on the day of proestrus after lesions or stimulation of the raphe nuclei in rats

Morello, Héctor; Taleisnik, S.

doi:10.1016/0006-8993(85)91247-8

Cited by 31 publications

(26 citation statements)

References 30 publications

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“…However, dorsal and median raphe nuclei play different roles in that regu lation. Whereas the dorsal raphe nuclei (DRn) facilitates the proestrous surge of LH, the medial raphe nucleus (MRn) is in hibitory [33]. In addition we have observed that different mech anisms are involved in these actions; while the inhibition of LH release on the day of proestrus evoked by lesions of DRn is mediated by the locus ceruleus, no such pathway is associated with the LH inhibition resulting from stimulation in the MRn [34].…”

mentioning

confidence: 73%

Inhibition of Proestrous LH Surge and Ovulation in Rats Evoked by Stimulation of the Medial Raphe Nucleus Involves a GABA-Mediated Mechanism

et al. 1989

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The neurotransmitters involved in the inhibition of luteinizing hormone (LH) release induced by electrochemical stimulation (anodic d.c, 100 µA/30 s) of the medial raphe nucleus (MRn) were studied. Stimulation applied at noon on the day of proestrus blocked the preovulatory surge of LH and ovulation. This effect was prevented by pretreating the animals (15 min before stimulation) with the 5-HT antagonist, methysergide (3.5 mg/kg, i.p.) The inhibition of LH release induced by stimulation of the MRn was also suppressed by the injection of the γ-aminobutyric acid (GABA) antagonists, picrotoxin (0.8 mg/kg, i.p.) and bicuculline (6 mg/kg, i.p.). Injection of 5-HT(15 µg) into the third ventricle on the day of proestrus mimicked the effect of MRn stimulation, a response which was prevented by methysergide, picrotoxin or bicuculline. An intraventricular injection of GABA (10 µg) also inhibited the preovulatory surge of LH and ovulation, but whereas the administration of bicuculline prevented the effect of GABA, that of methysergide failed to produce any change. It is concluded that stimulation of the MRn inhibits the proestrous surge of LH by activating a serotonergic pathway and that the effect is mediated by GABAergic neurons.

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mentioning

confidence: 73%

Inhibition of Proestrous LH Surge and Ovulation in Rats Evoked by Stimulation of the Medial Raphe Nucleus Involves a GABA-Mediated Mechanism

et al. 1989

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“…The serotonergic input from the raphe to the PVN might, therefore, provide an additional route for IL-l-mediated HPA activation. Rostra1 raphe stimulation has also been found to influence the secretion of hypothalamic growth hormone (Koibuchi et al, 1988) and pituitary luteinizing hormone (Morello and Taleisnik, 1985). Fifth, stimulation of the raphe, which sends dense serotonergic projections to the trigeminal nuclei and to the spinal cord (see Tork, 1985) elicits profound behavioral analgesia (Fields and Basbaum, 1978;Zieglgansberger, 1986) of the type reported to follow central IL-l administration (Nakamura et al, 1988).…”

Section: Discussionmentioning

confidence: 99%

In situ histochemical localization of type I interleukin-1 receptor messenger RNA in the central nervous system, pituitary, and adrenal gland of the mouse

et al. 1992

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The cytokine interleukin-1 (IL-l) has a number of biologic activities, including pronounced effects on the nervous and neuroendocrine systems. In this study, in situ histochemical techniques were used to investigate the distribution of cells expressing type I IL-1 receptor mRNA in the CNS, pituitary, and adrenal gland of the mouse. Hybridization of %-labeled antisense cRNA probes derived from a murine T-cell IL-1 receptor cDNA revealed a distinct regional distribution of the type I IL-1 receptor, both in brain and in the pituitary gland. In the brain, an intense signal was observed over the granule cell layer of the dentate gyrus, over the entire midline raphe system, over the choroid plexus, and over endothelial cells of postcapillary venules throughout the neuraxis. A weak to moderate signal was observed over the pyramidal ceil layer of the hilus and CA3 region of the hippocampus, over the anterodorsal thalamic nucleus, over Purkinje cells of the cerebellar cortex, and in scattered clusters over the externalmost layer of the median eminence.In the pituitary gland, a dense and homogeneously distributed signal was observed over the entire anterior lobe. No autoradiographic signal above background was observed over the posterior and intermediate lobes of the pituitary, or over the adrenal gland. This study therefore provides evidence for discrete receptor substrates subserving the central effects of IL-l, thus supporting the notion that IL-1 acts as a neurotransmitter/neuromodulator in brain. It also supports studies suggesting that IL-1 -mediated activation of the hypothalamic-pituitary-adrenal axis occurs primarily at the level of the brain and/or pituitary gland.Interleukin-1 (IL-l) is one of a growing number of cytokines that mediate important regulatory interactions between lymphocytes and many other cell types (see Dinarello, 1989). IL-l has also been identified as a key mediator in the acute-phase

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“…Le sioning of the DR blocks both the proestrous LH surge and ovulation [51,52]. Therefore, pre-surge activity of ANF-releasing neurons may be inhibitory to other DR cells that com municate with neurons in such regions as the locus ceruleus [52] to promote hypothalamic LHRH activity.…”

Section: Discussionmentioning

confidence: 99%

Atrial Natriuretic Factor Concentrations in Discrete Brain Regions, Pituitary, Cardiac Atria and Plasma during the Estrous Cycle in Rats

Hoffman¹,

MacPhee²,

Gerall³

1991

Neuroendocrinology

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Peripheral and central atrial natriuretic factor (ANF) concentrations were measured across the rat’s estrous cycle. Vaginal smears were obtained from adult Sprague-Dawley rats maintained under controlled illumination (L/D: 14/10, onset 05.00 h). ANF concentrations in plasma, cardiac atria, pituitary and nine microdissected brain regions of females (n = 5–13) were determined by radioimmunoassay during either early proestrus (09.00–11.00 h), late proestrus (17.00–19.00 h), estrus (09.00–11.00 h), early metestrus (09.00–11.00 h) and late metestrus (17.00–19.00 h). Patterns of cyclic ANF immunoreactivity in plasma and atria were inversely related to each other, with plasma levels being significantly elevated during early metestrus when atrial levels were significantly decreased. Statistically significant central fluctuations in ANF levels during the estrous cycle were only found in the hypothalamic periventricular region (hPVA) and in the dorsal raphe (DR). ANF levels declined in both regions after late proestrus. Results indicate a relationship between ANF activity and cyclic patterns of fluid volume regulation and with phasic reproductive hormonal events.

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Changes of the release of luteinizing hormone (LH) on the day of proestrus after lesions or stimulation of the raphe nuclei in rats

Cited by 31 publications

References 30 publications

Inhibition of Proestrous LH Surge and Ovulation in Rats Evoked by Stimulation of the Medial Raphe Nucleus Involves a GABA-Mediated Mechanism

Inhibition of Proestrous LH Surge and Ovulation in Rats Evoked by Stimulation of the Medial Raphe Nucleus Involves a GABA-Mediated Mechanism

In situ histochemical localization of type I interleukin-1 receptor messenger RNA in the central nervous system, pituitary, and adrenal gland of the mouse

Atrial Natriuretic Factor Concentrations in Discrete Brain Regions, Pituitary, Cardiac Atria and Plasma during the Estrous Cycle in Rats

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