Changes to cold detection and pain thresholds following low and high frequency transcranial magnetic stimulation of the motor cortex

Summers, Jeff; Johnson, Sama; Pridmore, Saxby; Oberoi, Gajinder

doi:10.1016/j.neulet.2004.07.008

Cited by 83 publications

(55 citation statements)

References 34 publications

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“…Stimulation of M1 with 1, 5 and 20 Hz rTMS has previously been shown to increase CDT in healthy subjects (Summers et al , 2004, Oliviero et al , 2005, although 10 Hz rTMS of M1 decreased CDT in one study (Nahmias et al , 2009), and both CDT and WDT in another study (Lefaucheur et al , 2008).…”

Section: Discussionmentioning

confidence: 88%

Non-invasive cortical modulation of experimental pain in migraine

Uglem

Omland

Engstrøm

et al. 2016

Clinical Neurophysiology

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Section: Discussionmentioning

confidence: 88%

Non-invasive cortical modulation of experimental pain in migraine

Uglem

Omland

Engstrøm

et al. 2016

Clinical Neurophysiology

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“…There would be considerable merit in the design of paradigms that incorporate independent and interacting conditions of pain and movement execution. Evidence from other sources, notably experiments employing transcranial magnetic stimulation [Summers et al, 2004;Svensson et al, 2003], would suggest that there is mutual inhibition of the primary motor and somatosensory cortices during pain and movement, respectively. It seems very likely that this type of interaction would also find expression in other components of the motor and pain networks.…”

Section: Discussionmentioning

confidence: 99%

Brain activity associated with painfully hot stimuli applied to the upper limb: A meta‐analysis

Farrell

Laird

Egan

2005

Human Brain Mapping

116

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Abstract:The capacity of pain to alert against potential injury or focus attention on damaged tissue is enhanced by the intrinsically aversive nature of the experience. Finding methods to relieve pain will ultimately be facilitated by deeper understanding of the processes that contribute to the experience, and functional brain imaging has contributed substantially toward that end. An impressive body of literature has identified a distributed network of pain-related activity in the brain that is subject to considerable modulation by different stimulus parameters, contextual factors, and clinical conditions. The fundamental substrates of the pain network are yet to be distilled from the highly variable results of studies published thus far. Qualitative reviews of the pain-imaging literature have been contributory, but lack the greater surety of quantitative methods. We employ the activation likelihood estimation (ALE) meta-analytic technique to establish the most consistent activations among studies reporting brain responses subsequent to the application of noxious heat. A network of pain-related activity was replicated for stimuli to either upper limb that included two discernible regions of the mid-anterior cingulate cortex, bilateral thalami, insula, and opercula cortices, posterior parietal cortex, premotor cortex, supplementary motor area, and cerebellum. The findings of the meta-analysis resonate with other streams of information that continue to enhance our understanding of pain in the brain. The results also point toward new areas of research that may be fruitful for the exploration of central pain processing. Hum Brain Mapp 25:129 -139, 2005.

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“…Further, high frequency rTMS of M1 in healthy populations show this technique can modulate experimental pain thresholds [16,26]. It is thought rTMS acts to modulate pathways from the insula and orbitofrontal cortex to the posterior thalamus in order to upregulate these pain thresholds [12].…”

Section: Rtmsmentioning

confidence: 99%

“…In contrast, high frequency rTMS (>5 Hz) has been shown to increase neuronal excitability and consequently lead to a parallel increase in pain thresholds [26]. According to a Cochrane review, 2010, [19] low frequency rTMS alone, was not worthy of further research as a possible intervention for chronic pain.…”

Section: Tdcs Priming To Enhance 1 Hz Rtmsmentioning

confidence: 99%