Changes underlying Halothane-induced Malignant Hyperpyrexia in Landrace Pigs

Berman, Mervyn C.; Harrison, Gillian; Bull, A. B.; Kench, J. E.

doi:10.1038/225653a0

Cited by 122 publications

(35 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…2), being around 0.5°C higher for the same point in time. This is in agreement with the literature, which shows that the drop in body temperature is recorded more quickly by the esophageal temperature probe than by the rectal thermometer [10,26,27,30]. In contrast to rectal temperature, which presented little oscillation over the monitoring time, esophageal temperature for group III showed an initial sharp drop at the moment of pneumoperitoneum installation, and then, when stimulated by it, started to go up again until around 60 min when the temperature returned to a normal pattern.…”

Section: Discussionsupporting

confidence: 87%

“…Thus, initial sedation was performed with a dissociative anesthetic, which permitted good induction and tracheal intubation and provided an anesthetic plan which would allow for better muscular relaxation [26]. Anesthetic induction was performed with sodium thiopental, which has little influence on the thermoregulatory center and had been used in previous thermoregulatory studies in pigs [23,27,28]. A muscle relaxant was also used in order to prevent heat production from the animal's tonus and contractions and to standardize respiratory rate and heat loss through the airways [26].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Body temperature evaluation during induced pneumoperitoneum with CO2: an experimental study in pigs

et al. 2012

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Body temperature evaluation during induced pneumoperitoneum with CO2: an experimental study in pigs

et al. 2012

View full text Add to dashboard Cite

show abstract

“…The increase of serum Ca*' in porcine malignant hyperthermia [3,10] suggests that the Ca*'-accumulating organelles might be defective in halothane-sensitive pigs, but up to date no significant malfunction in these organelles has been convincingly demonstrated. The report of a difference in the sarcoplasmic reticulum in stress-susceptible pigs [ 1 l] is most likely to be due to acid denaturation of these organelles as they were isolated from muscles having pH 5.4 -5.7.…”

Section: Introductionmentioning

confidence: 99%

Calcium movements in skeletal muscle mitochondria of malignant hyperthermic pigs

Cheah

1978

FEBS Letters

View full text Add to dashboard Cite

“…Wahren (1970) also observed the production of glucose by forearm musculature during intense exercise. It is known that about 8% of glycogen appears in the form of free glucose during glycogenolysis, but at normal rates of glycogen degradation this undergoes immediate phosphorylation (Field, 1960). Wahren (1970) suggested that glucose production by muscle arose as the result of extremely rapid glycogenolysis in the presence of increased glucose-6-phosphate concentrations which inhibit hexokinase.…”

Section: Discussionmentioning

confidence: 99%

“…Other local factors may have been responsible for the inadequate muscle blood flow. For example, muscle oedema and stiffness occur rapidly in MH (Berman et al, 1970) and may close thin-walled, low-pressure blood vessels. However, the increase in arterial adenosine values found during MH suggests that the release of local vasodilators by muscle occurred normally (Haddy and Scott, 1968).…”

Section: Discussionmentioning

confidence: 99%

Porcine Malignant Hyperthermia. Viii: Leg Metabolism

Hall

Lucre

Orchard

et al. 1982

British Journal of Anaesthesia

View full text Add to dashboard Cite

SUMMARYLeg metabolism during porcine malignant hyperthermia (MH) was investigated in eight Pietrain pigs. There was an efflux of glucose, lactate, pynivate and alanine from the leg during MH, demonstrating the occurrence of rapid glycogen degradation. Potassium production by the leg did not change significantly and the decrease in free fatty acid efflux together with the maintenance of grycerol production suggested the utilization of intramuscular triglycerides. The failure of leg blood flow to increase during MH limited the oxygen consumption of the muscle as maximal oxygen extraction occurred early in the response. In a further six Pietrain pigs it was shown that the infusion of sodium nitroprusside increased leg blood flow only slightly. It is possible that the inability of leg blood flow to increase in MH was a result of the decline in cardiac outputThere is surprisingly little information on the contribution of the increase in muscle metabolism during porcine malignant hyperthermia (MH) to the changes observed in circulating metabolites. It is, moreover, not possible to infer the contribution of skeletal muscle by studying changes in central venous metabolite values because of the important and variable effects of hepatic metabolism during MH (Hall et al., 1980). Therefore, in the present study we have systematically examined hind leg metabolism during MH and we have been obliged to use femoral arterial and venous blood samples. A single muscle preparation, such as gracilis in the dog, could not be developed in the pig because of the extremely small size of the peripheral blood vessels and the compact morphology of the leg muscles. A similar technique was used by Gronert and colleagues (Gronert, Milde and Theye, 1976a,b; Gronert and Theye, 1976) to quantify the increased muscle metabolism in MH, but the only substrates measured were lactate and pynivate.The results of the first experiment in the present studies showed that leg blood flow failed to increase to match the marked stimulation of muscle metabolism. Since Williams and colleagues have argued consistently that catecholamine-mediated vasoconstriction is a major factor in the pathogenesis of porcine MH (Williams, Hoech and Roberts, 1978; Williams etal., 1978), we undertook a second experiment to examine the effect of sodium nitroprusside (SNP) on leg blood flow and metabolism during MH. METHODSEight Pietrain pigs (mean weight 60 kg, SEM±2kg) from the Meat Research Institute's herd were studied. Anaesthesia was induced by an injection of thiopentone 10-15 mg kg" 1 through an ear vein. After intubation of the trachea, the lungs were ventilated with 66% nitrous oxide in oxygen using a Cape-Waine ventilator, and anaesthesia was maintained with incremental doses of thiopentone. Twenty-gauge Teflon cannulae, 3 cm long, were placed in both femoral arteries and veins approximately 1 cm distal to the femoral ring and the patency of the cannulae maintained by intermittent flushing with a 0.9% sodium chloride solution. A thermocouple was placed 10 cm deep int...

show abstract

Changes underlying Halothane-induced Malignant Hyperpyrexia in Landrace Pigs

Cited by 122 publications

References 8 publications

Body temperature evaluation during induced pneumoperitoneum with CO2: an experimental study in pigs

Body temperature evaluation during induced pneumoperitoneum with CO2: an experimental study in pigs

Calcium movements in skeletal muscle mitochondria of malignant hyperthermic pigs

Porcine Malignant Hyperthermia. Viii: Leg Metabolism

Contact Info

Product

Resources

About